scholarly journals Cardiac remodeling and pre-eclampsia: an overview of microRNA expression patterns

2018 ◽  
Vol 52 (3) ◽  
pp. 310-317 ◽  
Author(s):  
Z. Mohseni ◽  
M. E. A. Spaanderman ◽  
J. Oben ◽  
M. Calore ◽  
E. Derksen ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Expression Patterns ◽  
Microrna Expression

scholarly journals MicroRNA expression patterns in the bovine mammary gland are affected by stage of lactation

2012 ◽  
Vol 95 (11) ◽  
pp. 6529-6535 ◽  
Author(s):  
M. Wang ◽  
S. Moisá ◽  
M.J. Khan ◽  
J. Wang ◽  
D. Bu ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Expression Patterns ◽  
Microrna Expression ◽  
Bovine Mammary Gland ◽  
Stage Of Lactation

Identification of altered MicroRNA expression patterns in synovial sarcoma

2010 ◽  
Vol 50 (3) ◽  
pp. 137-145 ◽  
Author(s):  
Masanori Hisaoka ◽  
Atsuji Matsuyama ◽  
Yuichi Nagao ◽  
Lan Luan ◽  
Toshihiko Kuroda ◽  
...  
Keyword(s):  
Synovial Sarcoma ◽  
Expression Patterns ◽  
Microrna Expression

scholarly journals MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy

2017 ◽  
Vol 39 (5) ◽  
pp. 533-540 ◽  
Author(s):  
Ivyna Pau Ni Bong ◽  
Ching Ching Ng ◽  
Puteri Baharuddin ◽  
Zubaidah Zakaria
Keyword(s):  
Multiple Myeloma ◽  
Expression Patterns ◽  
Target Prediction ◽  
Microrna Expression

scholarly journals Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Evguenia Nepotchatykh ◽  
Wesam Elremaly ◽  
Iurie Caraus ◽  
Christian Godbout ◽  
Corinne Leveau ◽  
...  
Keyword(s):  
Treatment Options ◽  
Expression Patterns ◽  
Chronic Fatigue ◽  
Microrna Expression ◽  
Myalgic Encephalomyelitis ◽  
Circulating Microrna ◽  
Prevention Measures ◽  
Case Definitions ◽  
Specific Symptom ◽  
Fatigue Syndrome

AbstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. Post-exertional malaise (PEM), defined as the exacerbation of the patient's symptoms following minimal physical or mental stress, is a hallmark of ME/CFS. While multiple case definitions exist, there is currently no well-established biomarkers or laboratory tests to diagnose ME/CFS. Our study aimed to investigate circulating microRNA expression in severely ill ME/CFS patients before and after an innovative stress challenge that stimulates PEM. Our findings highlight the differential expression of eleven microRNAs associated with a physiological response to PEM. The present study uncovers specific microRNA expression signatures associated with ME/CFS in response to PEM induction and reports microRNA expression patterns associated to specific symptom severities. The identification of distinctive microRNA expression signatures for ME/CFS through a provocation challenge is essential for the elucidation of the ME/CFS pathophysiology, and lead to accurate diagnoses, prevention measures, and effective treatment options.

scholarly journals The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome

Function ◽  
2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Conor McClenaghan ◽  
Yan Huang ◽  
Scot J Matkovich ◽  
Attila Kovacs ◽  
Carla J Weinheimer ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Potassium Channel ◽  
Cardiac Remodeling ◽  
Expression Patterns ◽  
Katp Channels ◽  
Gain Of Function ◽  
High Output Heart Failure ◽  
Altered Gene ◽  
Cardiac Enlargement ◽  
High Output

Abstract Dramatic cardiomegaly arising from gain-of-function (GoF) mutations in the ATP-sensitive potassium (KATP) channels genes, ABCC9 and KCNJ8, is a characteristic feature of Cantú syndrome (CS). How potassium channel over-activity results in cardiac hypertrophy, as well as the long-term consequences of cardiovascular remodeling in CS, is unknown. Using genome-edited mouse models of CS, we therefore sought to dissect the pathophysiological mechanisms linking KATP channel GoF to cardiac remodeling. We demonstrate that chronic reduction of systemic vascular resistance in CS is accompanied by elevated renin–angiotensin signaling, which drives cardiac enlargement and blood volume expansion. Cardiac enlargement in CS results in elevation of basal cardiac output, which is preserved in aging. However, the cardiac remodeling includes altered gene expression patterns that are associated with pathological hypertrophy and are accompanied by decreased exercise tolerance, suggestive of reduced cardiac reserve. Our results identify a high-output cardiac hypertrophy phenotype in CS which is etiologically and mechanistically distinct from other myocardial hypertrophies, and which exhibits key features of high-output heart failure (HOHF). We propose that CS is a genetically-defined HOHF disorder and that decreased vascular smooth muscle excitability is a novel mechanism for HOHF pathogenesis.

Abstract A25: Differences in microRNA expression patterns in breast cancer subtypes

2012 ◽  
Vol 72 (2 Supplement) ◽  
pp. A25-A25
Author(s):  
Sandra L. Romero-Cordoba ◽  
Rosa G. Rebollar-Vega ◽  
Valeria Quintanar-Jurado ◽  
Veronica Bautista-Pina ◽  
Sergio Rodriguez-Cuevas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Expression Patterns ◽  
Microrna Expression ◽  
Breast Cancer Subtypes ◽  
Cancer Subtypes
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