scholarly journals Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes

Oncotarget ◽  
2016 ◽  
Vol 7 (37) ◽  
pp. 59902-59916 ◽  
Author(s):  
Yuan-Yun Tseng ◽  
Chen-Hsing Su ◽  
Shun-Tai Yang ◽  
Yin-Chen Huang ◽  
Wei-Hwa Lee ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Targeted Treatment ◽  
Interstitial Chemotherapy ◽  
Nanofibrous Membranes

scholarly journals Concurrent Chemotherapy of Malignant Glioma in Rats by Using Multidrug-Loaded Biodegradable Nanofibrous Membranes

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuan-Yun Tseng ◽  
Yin-Chen Huang ◽  
Tao-Chieh Yang ◽  
Shun-Tai Yang ◽  
Shou-Cheng Liu ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Concurrent Chemotherapy ◽  
Nanofibrous Membranes

scholarly journals SCDT-10. OVERALL SURVIVAL IN AN ORTHOTOPIC MALIGNANT GLIOMA MODEL IS SIGNIFICANTLY PROLONGED BY NEUROSURGICAL DELIVERY OF PLGA/PEG INTERSTITIAL CHEMOTHERAPY PASTE

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi266-vi267
Author(s):  
Stuart Smith ◽  
Betty Tyler ◽  
Toby Gould ◽  
Gareth Veal ◽  
Alison Ritchie ◽  
...  
Keyword(s):  
Overall Survival ◽  
Malignant Glioma ◽  
Interstitial Chemotherapy ◽  
Glioma Model

Advanced interstitial chemotherapy for treating malignant glioma

2016 ◽  
Vol 13 (11) ◽  
pp. 1533-1544 ◽  
Author(s):  
Yuan-Yun Tseng ◽  
Yi-Chuan Kau ◽  
Shih-Jung Liu
Keyword(s):  
Malignant Glioma ◽  
Interstitial Chemotherapy

Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas

1991 ◽  
Vol 74 (3) ◽  
pp. 441-446 ◽  
Author(s):  
Henry Brem ◽  
M. Stephen Mahaley ◽  
Nicholas A. Vick ◽  
Keith L. Black ◽  
S. Clifford Schold ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Dose Group ◽  
Malignant Gliomas ◽  
Chemotherapeutic Agents ◽  
Therapeutic Drug ◽  
Recurrent Malignant Glioma ◽  
Content Type ◽  
Interstitial Chemotherapy ◽  
Bcnu Wafer ◽  
Fine Print

✓ Malignant gliomas have been difficult to treat with chemotherapy. The most effective agent, BCNU (carmustine), has considerable systemic toxicity and a short half-life in serum. To obviate these problems, a method has been developed for the local sustained release of chemotherapeutic agents by their incorporation into biodegradable polymers. Implantation of the drug-impregnated polymer at the tumor site allows prolonged local exposure with minimal systemic exposure. In this Phase I–II study, 21 patients with recurrent malignant glioma were treated with BCNU released interstitially by means of a polyanhydride biodegradable polymer implant. Up to eight polymer wafers were placed in the resection cavity intraoperatively, upon completion of tumor debulking. The polymer releases the therapeutic drug for approximately 3 weeks. Three increasing concentrations of BCNU were studied; the treatment was well tolerated at all three levels. There were no adverse reactions to the BCNU wafer treatment itself The average survival period after reoperation was 65 weeks for the first dose group, 64 weeks for the second dose group, and 32 weeks for the highest dose group. The overall mean survival time was 48 weeks from reoperation and 94 weeks from the original operation. The overall median survival times were 46 weeks postimplant and 87 weeks from initial surgery. Eighteen (86%) of 21 patients lived more than 1 year from the time of their initial diagnosis and eight (38%) of 21 patients lived more than 1 year after intracranial implantation of the polymer. Frequent hematology, blood chemistry, and urinalysis tests did not reveal any systemic effect from this interstitial chemotherapy. Since the therapy is well tolerated and safe, a placebo-controlled clinical trial has been started. The trial will measure the effect of the second treatment dose on survival of patients with recurrent malignant glioma.

Interstitial chemotherapy with mitoxantrone in recurrent malignant glioma: preliminary data

1996 ◽  
Vol 27 (2) ◽  
Author(s):  
Amerigo Boiardi ◽  
Andrea Salmaggi ◽  
Annalisa Pozzi ◽  
Giovanni Broggi ◽  
Antonio Silvani
Keyword(s):  
Malignant Glioma ◽  
Preliminary Data ◽  
Recurrent Malignant Glioma ◽  
Interstitial Chemotherapy

Therapeutic management of malignant glioma in pregnancy: a case report highlighting clinical and radiological features at diagnosis and after intervention

2020 ◽  
Vol 3 (68) ◽  
pp. 147
Author(s):  
Ioniţă Ducu ◽  
Roxana-Elena Bohîlţea ◽  
Dan Teleanu ◽  
Natalia Ţurcan ◽  
Monica Mihaela Cîrstoiu
Keyword(s):  
Case Report ◽  
Malignant Glioma ◽  
Therapeutic Management ◽  
Radiological Features ◽  
In Pregnancy
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