scholarly journals Concurrent Chemotherapy of Malignant Glioma in Rats by Using Multidrug-Loaded Biodegradable Nanofibrous Membranes

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuan-Yun Tseng ◽  
Yin-Chen Huang ◽  
Tao-Chieh Yang ◽  
Shun-Tai Yang ◽  
Shou-Cheng Liu ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Concurrent Chemotherapy ◽  
Nanofibrous Membranes

scholarly journals Hypofractionated stereotactic radiosurgery with concurrent bevacizumab for recurrent malignant gliomas: the University of Alabama at Birmingham experience

2014 ◽  
Vol 1 (4) ◽  
pp. 172-177 ◽  
Author(s):  
Grant M. Clark ◽  
Andrew M. McDonald ◽  
Louis B. Nabors ◽  
Hassan Fathalla-Shaykh ◽  
Xiaosi Han ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Stereotactic Radiosurgery ◽  
Karnofsky Performance Status ◽  
Performance Status ◽  
Malignant Gliomas ◽  
Concurrent Chemotherapy ◽  
Who Grade ◽  
Volume Delineation ◽  
Grade 3 ◽  
Hypofractionated Stereotactic Radiosurgery

Abstract Background Nearly all patients with malignant glioma will have disease recurrence. Our purpose was to define the treatment toxicity and efficacy of concurrent bevazicumab (BVZ) with hypofractionated stereotactic radiosurgery (SRS) of relatively larger targets for patients with recurrent MG. Methods A retrospective review of 21 patients with recurrent malignant glioma (18 glioblastoma, 3 WHO grade III glioma), treated at initial diagnosis with surgery and standard chemoradiation, was performed. All patients had concurrent BVZ with hypofractionatedSRS, 30 Gy in 5 fractions, with or without concurrent chemotherapy (temozolomide or CCNU). Results Median patient age was 54 years, median Karnofsky Performance Status was 80, and median target size was 4.3 cm (range, 3.4–7.5 cm). Eleven patients (52%) had previously failed BVZ. One patient had grade 3 toxicities (seizures, dysphasia), which resolved with inpatient admission and intravenous steroids/antiepileptics. Treatment-related toxicities were grade 3 (n = 1), grade 2 (n = 9), and grade 0–1 (n = 11). Kaplan-Meier median progression-free survival and overall survival estimates (calculated from start of SRS) for GBM patients (n = 18) were 11.0 and 12.5 months, respectively. Concurrent chemotherapy did not appear to show any statistically significant efficacy benefit or have any propensity for toxicity. Conclusion BVZ concurrent with hypofractionated SRS was well tolerated by this cohort of patients with relatively larger targets. Ongoing randomized trials with more moderate radiotherapy dosing may help establish the efficacy of this regimen, though intricacies of this approach, including patient selection, radiation target volume delineation/size, and optimal radiation dose, will need further evaluation.

scholarly journals Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes

Oncotarget ◽  
2016 ◽  
Vol 7 (37) ◽  
pp. 59902-59916 ◽  
Author(s):  
Yuan-Yun Tseng ◽  
Chen-Hsing Su ◽  
Shun-Tai Yang ◽  
Yin-Chen Huang ◽  
Wei-Hwa Lee ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Targeted Treatment ◽  
Interstitial Chemotherapy ◽  
Nanofibrous Membranes

Therapeutic management of malignant glioma in pregnancy: a case report highlighting clinical and radiological features at diagnosis and after intervention

2020 ◽  
Vol 3 (68) ◽  
pp. 147
Author(s):  
Ioniţă Ducu ◽  
Roxana-Elena Bohîlţea ◽  
Dan Teleanu ◽  
Natalia Ţurcan ◽  
Monica Mihaela Cîrstoiu
Keyword(s):  
Case Report ◽  
Malignant Glioma ◽  
Therapeutic Management ◽  
Radiological Features ◽  
In Pregnancy
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