scholarly journals Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

Oncotarget ◽  
2016 ◽  
Vol 7 (31) ◽  
pp. 50277-50289 ◽  
Author(s):  
Luuk van Hooren ◽  
Maria Georganaki ◽  
Hua Huang ◽  
Sara M. Mangsbo ◽  
Anna Dimberg
Keyword(s):  
T Cell ◽  
Endothelial Activation ◽  
Cell Recruitment ◽  
Agonistic Cd40 Antibody

scholarly journals SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ye Wang ◽  
Morvarid Mohseni ◽  
Angelo Grauel ◽  
Javier Estrada Diez ◽  
Wei Guan ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Immunity ◽  
Immune Cell ◽  
Tumor Regression ◽  
Tyrosine Phosphatase ◽  
Cytotoxic T Cell ◽  
Cell Recruitment ◽  
Inhibitory Function ◽  
Immune Mediated ◽  
Cytotoxic Function

AbstractSHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allosteric SHP2 inhibitors promoted anti-tumor immunity, including enhancing T cell cytotoxic function and immune-mediated tumor regression. Knockout of SHP2 using CRISPR/Cas9 gene editing showed that targeting SHP2 in cancer cells contributes to this immune response. Inhibition of SHP2 activity augmented tumor intrinsic IFNγ signaling resulting in enhanced chemoattractant cytokine release and cytotoxic T cell recruitment, as well as increased expression of MHC Class I and PD-L1 on the cancer cell surface. Furthermore, SHP2 inhibition diminished the differentiation and inhibitory function of immune suppressive myeloid cells in the tumor microenvironment. SHP2 inhibition enhanced responses to anti-PD-1 blockade in syngeneic mouse models. Overall, our study reveals novel functions of SHP2 in tumor immunity and proposes that targeting SHP2 is a promising strategy for cancer immunotherapy.

scholarly journals CCL22-Producing CD8α− Myeloid Dendritic Cells Mediate Regulatory T Cell Recruitment in Response to G-CSF Treatment

2013 ◽  
Vol 191 (5) ◽  
pp. 2266-2272 ◽  
Author(s):  
Esther Layseca-Espinosa ◽  
Sarantis Korniotis ◽  
Ruddy Montandon ◽  
Christophe Gras ◽  
Marie Bouillié ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Regulatory T Cell ◽  
Myeloid Dendritic Cells ◽  
Cell Recruitment

Proinflammatory Oscillations Over the Menstrual Cycle Drives Bystander CD4 T Cell Recruitment and SHIV Susceptibility from Vaginal Challenge

2021 ◽  
Author(s):  
Alison Swaims-Kohlmeier ◽  
Jed Brody ◽  
Anandi Sheth ◽  
Felicia P. Hardnett ◽  
Sunita Sharma ◽  
...  
Keyword(s):  
T Cell ◽  
Menstrual Cycle ◽  
Cd4 T Cell ◽  
Cell Recruitment

scholarly journals Local Application of Autologous Platelet-Rich Fibrin Patch (PRF-P) Suppresses Regulatory T Cell Recruitment in a Murine Glioma Model

2018 ◽  
Vol 56 (7) ◽  
pp. 5032-5040 ◽  
Author(s):  
Wojciech K. Panek ◽  
Katarzyna C. Pituch ◽  
Jason Miska ◽  
Julius W. Kim ◽  
Aida Rashidi ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Local Application ◽  
Cell Recruitment ◽  
Platelet Rich Fibrin ◽  
Glioma Model ◽  
Autologous Platelet ◽  
Murine Glioma
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