scholarly journals Targeted proteomic approach in prostatic tissue: a panel of potential biomarkers for cancer detection

Oncoscience ◽  
2016 ◽  
Vol 3 (7-8) ◽  
pp. 220-241 ◽  
Author(s):  
Donatella Aiello ◽  
Francesca Casadonte ◽  
Rosa Terracciano ◽  
Rocco Damiano ◽  
Rocco Savino ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Prostatic Tissue ◽  
Proteomic Approach ◽  
Potential Biomarkers

scholarly journals Ovarian Cancer Biomarkers: Current Options and Future Promise

2008 ◽  
Vol 6 (8) ◽  
pp. 795-802 ◽  
Author(s):  
Christine M. Coticchia ◽  
Jiang Yang ◽  
Marsha A. Moses
Keyword(s):  
Ovarian Cancer ◽  
Disease Progression ◽  
Cancer Detection ◽  
Therapeutic Efficacy ◽  
Cancer Biomarkers ◽  
Cancer Diagnostics ◽  
Early Disease ◽  
Molecular Approaches ◽  
Ovarian Cancer Diagnostics ◽  
Potential Biomarkers

As more effective, less toxic cancer drugs reach patients, the need for accurate and reliable cancer diagnostics and prognostics has become widely appreciated. Nowhere is this need more dire than in ovarian cancer; here most women are diagnosed late in disease progression. The ability to sensitively and specifically predict the presence of early disease and its status, stage, and associated therapeutic efficacy has the potential to revolutionize ovarian cancer detection and treatment. This article reviews current ovarian cancer diagnostics and prognostics and potential biomarkers that are being studied and validated. Some of the most recent molecular approaches being used to identify genes and proteins are presented, which may represent the next generation of ovarian cancer diagnostics and prognostics.

scholarly journals miRNAs as potential biomarkers in early breast cancer detection following mammography

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Sidney W. Fu ◽  
Woojin Lee ◽  
Caitrin Coffey ◽  
Alexa Lean ◽  
Xiaoling Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Cancer Detection ◽  
Breast Cancer Detection ◽  
Potential Biomarkers

A proteomic approach to investigate potential biomarkers directed against membrane-associated breast cancer proteins

2006 ◽  
Vol 27 (8) ◽  
pp. 1609-1616 ◽  
Author(s):  
Ludovic Canelle ◽  
Jordane Bousquet ◽  
Cedric Pionneau ◽  
Julie Hardouin ◽  
Genevieve Choquet-Kastylevsky ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Proteomic Approach ◽  
Potential Biomarkers

scholarly journals Plasma microRNAs, miR-223, miR-21 and miR-218, as Novel Potential Biomarkers for Gastric Cancer Detection

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41629 ◽  
Author(s):  
Bo-sheng Li ◽  
Yong-liang Zhao ◽  
Gang Guo ◽  
Wei Li ◽  
En-dong Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Detection ◽  
Potential Biomarkers

scholarly journals Identification of potential biomarkers of head and neck squamous cell carcinoma using iTRAQ based quantitative proteomic approach

Data in Brief ◽  
2018 ◽  
Vol 19 ◽  
pp. 1124-1130 ◽  
Author(s):  
Niraj Babu ◽  
Sonali Mohan ◽  
Vishalakshi Nanjappa ◽  
Sandip Chavan ◽  
Jayshree Advani ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Proteomic Approach ◽  
Potential Biomarkers

scholarly journals A Quantitative Proteomic Approach for Identification of Potential Biomarkers in Hepatocellular Carcinoma

2008 ◽  
Vol 7 (10) ◽  
pp. 4289-4298 ◽  
Author(s):  
Raghothama Chaerkady ◽  
H. C. Harsha ◽  
Anuradha Nalli ◽  
Marjan Gucek ◽  
Perumal Vivekanandan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Proteomic Approach ◽  
Potential Biomarkers

scholarly journals Proteomic Approach for Identification of IgA Nephropathy-Related Biomarkers in Urine

2017 ◽  
pp. 621-632 ◽  
Author(s):  
P. PRIKRYL ◽  
L. VOJTOVA ◽  
D. MAIXNEROVA ◽  
M. VOKURKA ◽  
M. NEPRASOVA ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Kidney Diseases ◽  
Surrogate Marker ◽  
Pilot Project ◽  
Protein Quantification ◽  
Absolute Quantitation ◽  
Proteomic Approach ◽  
Isobaric Tag ◽  
Alpha 1 Antitrypsin ◽  
Potential Biomarkers

Proteinuria is often used as a surrogate marker in monitoring and predicting outcome in patients with chronic kidney diseases, but it is non-specific. IgAN belongs to the most common primary glomerulonephritis worldwide with serious prognosis. The main aim of this work was to assess differences in urine proteins in patients with IgA nephropathy and to identify abnormal proteins as potential biomarkers of IgA nephropathy or the renal disease. In our pilot project, we selected 20 patients and compared them with 20 healthy volunteers. Protein quantification was performed using iTRAQ (isobaric tag for relative and absolute quantitation) labeling method. The peptides were separated by the isoelectric focusing method (IEF) and nano-LC with C18 column and identified by mass spectrometry using MALDI-TOF/TOF MS. Proteins´ lists obtained from IEF-LC-MS-MS/MS analysis were combined and contained 201 proteins. It was found out that 113 proteins were common in both experiments. 30 urinary proteins were significantly up- or down-regulated in patients with IgA nephropathy. We characterized potential biomarkers such as alpha-1-antitrypsin, apolipoprotein A-I, CD44 antigen or kininogen. Potential biomarkers of IgAN should be validated in further studies.

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