scholarly journals Early elevation of BACE1 in dementia

Aging ◽  
2021 ◽  
Author(s):  
Carlo Cervellati ◽  
Giuseppe Valacchi ◽  
Giovanni Zuliani
Keyword(s):  
Early Elevation

Early elevation of factor IX level in japanese brothers with Haemophilia B Leyden who are carrying c. ‐35 g > a mutations in the promoter region of F9

Haemophilia ◽  
2021 ◽  
Author(s):  
Akihiro Tamura ◽  
Keiko Shinozawa ◽  
Suguru Uemura ◽  
Sayaka Nakamura ◽  
Takahiro Fujiwara ◽  
...  
Keyword(s):  
Promoter Region ◽  
Factor Ix ◽  
Haemophilia B ◽  
Early Elevation

Abstract WP138: Effects of Intensive Medical Management (IMM) and Encephaloduroarteriosynangiosis (EDAS) On VEGFA165a/b Ratios in Patients With Intracranial Atherosclerosis (ICASi

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Nestor R Gonzalez ◽  
Raymond Liou ◽  
Yinn Ooi ◽  
Jason D Hinman ◽  
Neal Rao ◽  
...  
Keyword(s):  
Prospective Observational Study ◽  
Mixed Model ◽  
Sandwich Elisa ◽  
Repeated Measurements ◽  
Likelihood Method ◽  
Outcome Variable ◽  
Serum Samples ◽  
Persistent Symptoms ◽  
Early Elevation

Objective: VEGFA isoforms 165a and 165b are pro and antiangiogenic, respectively. We aimed to evaluate the effects of IMM and EDAS in the VEGFA165a/b ratio in patients with ICAS. Methods: This is a prospective observational study of VEGFA165a and b in patients with stenosis greater than 70% due to ICAS. All patients received IMM. Patients with persistent symptoms underwent EDAS while maintaining IMM. Serum samples were collected at baseline, 1 week, 1, 3, and 6 months. VEGFA isoforms were quantified using multiplex sandwich ELISA. All samples were run in duplicate and accepted as valid if the intersample variability was less than 20%. A mixed model was built for the outcome variable VEGFA165a/b ratio using the predictor variables timepoint, treatment, and the interaction of time and treatment. The restricted maximum likelihood method was used to fit the model with random effects to account for the repeated measurements and intersubject variability. Results: A total of 72 patients were enrolled, of which 58 had IMM alone and 14 had EDAS. Mean age was 61.8 ± 12.3, 53% were females. The regression model demonstrated that there were no significant differences in the VEGFA165a/b ratio at baseline and 1 month after enrollment. Significant differences in VEGFA165a/b ratio were found at one week with higher levels in the surgical group (EDAS: 0.46 ± 0.22, IMM: 0.24 ± 0.07, p=0.03) and at 3 and 6 months with higher levels in the IMM group (3m: EDAS: 0.29 ± 0.14, IMM: 0.45 ± 0.20, p=0.03, 6m: EDAS:0.19 ± 0.11, IMM 0.37 ± 0.19 p=0.01). Conclusion: While the surgical event may well explain the early elevation of the VEGFA165a/b ratio one week after surgery, the elevation of a proangiogenic profile by the 3rd and 6th month in the IMM group is relevant. None of the patients in the IMM or EDAS groups had strokes at the last 6 months follow-up, and the peak (early for EDAS and at 3 and 6 months for IMM) of the VEGFA165a/b ratio may indicate a protective effect, averting stroke.

Early elevation of cathepsin B1 in human muscle disease

1977 ◽  
Vol 18 (1) ◽  
pp. 126-129 ◽  
Author(s):  
Nirmal C. Kar ◽  
Carl M. Pearson
Keyword(s):  
Human Muscle ◽  
Muscle Disease ◽  
Early Elevation

scholarly journals Neural dynamics of retrieval suppression in abolishing item-specific cortical pattern of unwanted emotional memories

2021 ◽  
Author(s):  
Xuanyi Lin ◽  
Danni Chen ◽  
Ziqing Yao ◽  
Michael Anderson ◽  
Xiaoqing Hu
Keyword(s):  
Time Domain ◽  
Neural Dynamics ◽  
Pattern Completion ◽  
Time Frequency ◽  
Emotional Memories ◽  
Item Level ◽  
Passive Viewing ◽  
Unpleasant Experience ◽  
Insight Into ◽  
Early Elevation

When reminded of an unpleasant experience, people often try to exclude the unwanted memory from awareness in an effort to forget it, a process known as retrieval suppression. Yet, how fast can individual memories be targeted and controlled, and the neural dynamics in modulating cortical traces of individual memories, remain elusive. Here, using multivariate decoding analyses on time-domain and time-frequency-domain EEGs, we found that retrieval suppression of aversive memories was distinct from retrieval and passive viewing, when given a reminder. Specifically, early elevation of mid-frontal theta power during the first 500 ms distinguished retrieval suppression from passive viewing, suggesting that suppression recruited early active control processes. On an item-level, we could discern activities relating to individual memories during active retrieval-initially, based on perceptual responses to reminders (0-500 ms) and later, via the reinstatement and maintenance of the target aversive scenes (500-3000 ms). Critically, suppressing retrieval significantly weakened (during 420-600 ms) and eventually abolished these item-specific cortical patterns till cue disappeared (1200-3000 ms), suggesting the successful exclusion of the unwelcome memory from awareness. Suppression of item-specific cortical patterns bore behavioral consequences in predicting subsequent episodic forgetting. These findings provide unique insight into the neural dynamics underlying the control of unwelcome memories: upon perceiving an unwelcome reminder, people rapidly deploy inhibitory control to truncate retrieval within 500 ms, which likely terminate the reminder-to-memory conversion at around 500 ms that would ordinarily arise through hippocampal pattern completion. We concluded that both rapid and sustained control are critical in abolishing cortical patterns of individual memories, limiting unwelcome awareness, and precipitating later forgetting.

Abstract TMP106: Early Elevation of D-dimer Values Is Associated With Neurological Deterioration in Acute Ischemic Stroke due to Cerebral Artery Dissection

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Kazuki Fukuma ◽  
Masafumi Ihara ◽  
Hiroshi Yamagami ◽  
Masatoshi Koga ◽  
Kazunori Toyoda ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Aortic Dissection ◽  
Acute Ischemic Stroke ◽  
Anticoagulant Therapy ◽  
Cerebral Artery ◽  
Neurological Deterioration ◽  
Artery Dissection ◽  
Cerebral Artery Dissection ◽  
D Dimer ◽  
Early Elevation

Background and Purpose: Plasma D-dimer is a complementary diagnostic marker in patients with acute aortic dissection. However, it remains unknown whether monitoring of D-dimer is of diagnostic value for in-hospital management of cerebral artery dissection. The aim of this study was to identify the relationship between D-dimer and neurological deterioration in acute ischemic stroke due to cerebral artery dissection. Methods: We retrospectively studied 90 consecutive patients (60 men; mean age, 51.0 years) with ischemic stroke due to cerebral or cervical artery dissection who were admitted to our hospital within three weeks after the onset between Jan 2005 and May 2015. Plasma D-dimer values were measured at least on admission and within a week. Neurological deterioration (ND) was defined as an increase of ≥ 3 points in the National Institutes of Health Stroke Scale (NIHSS) score within 3 weeks after admission. D-dimer ratio (DDR, peak D-dimer between the 2nd and 7th hospital day / on admission) was measured as an index of D-dimer elevation at an early phase. Associations between ND and patient characteristics including D-dimer values and acute treatment regimen were examined. Results: Eight of the 90 patients (8.9%) presented ND, accompanied by progression of stenosis in cerebral artery dissection. None of them had aortic dissection, severe heart failure and active malignant tumor. Fifty-nine of the 90 patients (65.6%) received anticoagulant therapy, 33 (36.7%) antiplatelet therapy and 5 (5.6%) thrombolysis in the acute phase. The mean D-dimer value was 2.80±1.81 (standard deviation, SD) at the time of progression. In univariate analysis, DDR was higher in ND group (3.93±2.45 SD) than non-ND group (1.46±1.04 SD) (p<0.01), whereas the D-dimer value on admission was similar in 2 groups . Multivariate logistic regression analysis showed DDR was related to ND before [OR: 1.57; 95% CI: 1.15-2.38, p<0.01] and after controlling for thrombolysis, anticoagulant therapy and deep vein thrombosis [OR: 1.63; 95% CI: 1.14-2.62, p<0.01]. Conclusion: Early elevation of D-dimer values may predict neurological deterioration with progression of stenosis in acute ischemic stroke due to cerebral artery dissection

Sign in / Sign up

Export Citation Format

Share Document