scholarly journals Involvement of c-Myc in low dose radiation-induced senescence enhanced migration and invasion of unirradiated cancer cells

Aging ◽  
2021 ◽  
Author(s):  
Jyh-Der Leu ◽  
Chung-Yih Wang ◽  
Chia-Chien Lo ◽  
Min-Ying Lin ◽  
Chun-Yuan Chang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Low Dose ◽  
Migration And Invasion ◽  
Low Dose Radiation ◽  
Radiation Induced ◽  
Dose Radiation

scholarly journals Low-Dose Radiation-Induced Senescent Stromal Fibroblasts Render Nearby Breast Cancer Cells Radioresistant

2009 ◽  
Vol 172 (3) ◽  
pp. 306-313 ◽  
Author(s):  
Kelvin K. C. Tsai ◽  
Jeremy Stuart ◽  
Yao-Yu Eric Chuang ◽  
John B. Little ◽  
Zhi-Min Yuan
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Low Dose ◽  
Low Dose Radiation ◽  
Stromal Fibroblasts ◽  
Radiation Induced ◽  
Dose Radiation

Low-dose radiation-induced acute pericarditis (AP) in breast cancer patient

2013 ◽  
Vol 18 ◽  
pp. S179-S180 ◽  
Author(s):  
I. Alastuey ◽  
A. Noé ◽  
C. Chiaramello ◽  
S. Montemuiño ◽  
J. Pardo
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Low Dose ◽  
Low Dose Radiation ◽  
Acute Pericarditis ◽  
Radiation Induced ◽  
Dose Radiation

scholarly journals The Effect of Docetaxel (Taxotere®) on Human Gastric Cancer Cells Exhibiting Low-Dose Radiation Hypersensitivity

2008 ◽  
Vol 2 ◽  
pp. CMO.S463
Author(s):  
Elizabeth K. Balcer-Kubiczek ◽  
Mona Attarpour ◽  
Jian Z. Wang ◽  
William F. Regine
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Time Course ◽  
Low Dose ◽  
Immunoblot Analysis ◽  
Human Gastric Cancer ◽  
Low Dose Radiation ◽  
Gastric Cancer Cells ◽  
Dose Radiation

Low-dose radiation hypersensitivity (HRS) describes a phenomenon of excessive sensitivity to X ray doses <0.5 Gy. Docetaxel is a taxane shown to arrest cells in the G2/M phase of the cell cycle. Some previous studies suggested that HRS might result from the abrogation of the early G2 checkpoint arrest. First we tested whether HRS occurs in gastric cancer—derived cells, and whether pre-treatment of cells with low docetaxel concentrations can enhance the magnitude of HRS in gastric cancer cells. The results demonstrated HRS at ~0.3 Gy and the synergy between 0.3 Gy and docetaxel (3 nM for 24 h), and the additivity of other drug/dose combinations. The synergistic effect was associated with a significant docetaxel-induced G2 accumulation. Next, we evaluated in time-course experiments ATM kinase activity and proteins associated with the induction and maintenance of the early G2 checkpoint. The results of multi-immunoblot analysis demonstrate that HRS does not correlate with the ATM-dependent early G2 checkpoint arrest. We speculate that G2 checkpoint adaptation, a phenomenon associated with a prolonged cell cycle arrest, might be involved in HRS. Our results also suggest a new approach for the improvement the effectiveness of docetaxel-based radiotherapy using low doses per fraction.

Effect of caffeine treatment on low-dose γ- irradiation-induced chromatid-type aberrations in human leukemia cells and human normal fibroblast cells in culture

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22113-e22113
Author(s):  
M. N. Jha ◽  
J. S. Bedford ◽  
S. Jha ◽  
K. Prasad
Keyword(s):  
T Cells ◽  
Gamma Radiation ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Low Dose ◽  
Leukemia Cells ◽  
Low Dose Radiation ◽  
Normal Cells ◽  
G2 Delay ◽  
Dose Radiation

e22113 Background: It is estimated that low dose radiation can increase the risk of cancer as well as mutations. However, the interaction of low dose radiation with caffeine has not been adequately investigated. We investigated the effects of caffeine on low dose- gamma-radiation-induced chromosomal damage in human T leukemia cells (Jurket T-cells) and two normal human fibroblast cell lines (AG1522 and GM 2149). Method: Jurkat cells were maintained in RPMI 1640 medium and fibroblast in alpha-minimal essential medium (MEM) All cells were incubated at 37o C in a humidified atmosphere of 5% CO2 in air. Cells from the exponential phase were treated with 1 mg/ml caffeine ( control cells received same amount of solvent) and irradiated with low doses (3, 5, 10, 20 and 40 cGy,), using a 137 Cs-gamma radiation source. Colcemid at a concentration of 0.1 μg/ml was added to every flask. Cells were fixed in methanol: acetic acid solution and stained with Giemsa. 100 irradiated and un-irradiated metaphase- like cells were scored for chromatid-type aberrations. Results: Low dose gamma-radiation increased the levels of chromatid breaks(dose dependent) in both normal and cancer cells; however, cancer cells appeared to be more sensitive than the normal cells. Caffeine treatment markedly increased chromatid aberrations in Jurkat T-cells at all radiation doses but not in normal cells. Previously, we reported that caffeine eliminates gamma-ray-induced G2 delay in other human tumor cells but not normal cells (Jha, et.al., Radiat. Res. 157, 26–31, 2002). Conclusions: The mechanisms that may underlie this differential effect of caffeine in cancer and normal cells are unknown, but if one result of a G2 delay is to allow more time for chromosome breakage rejoining processes to occur, then elimination of this delay by caffeine in tumor cells but not normal cells might account for the difference. To the extent these observations are generally true for tumor vs normal cells, the differential sensitization could have an impact in improving the efficacy of radiation therapy. No significant financial relationships to disclose.

scholarly journals Low-dose radiation-induced apoptosis in human leukemia K562 cells through mitochondrial pathways

2014 ◽  
Vol 10 (3) ◽  
pp. 1569-1575 ◽  
Author(s):  
YONG XIN ◽  
HAI-BIN ZHANG ◽  
TIAN-YOU TANG ◽  
GUI-HONG LIU ◽  
JIAN-SHE WANG ◽  
...  
Keyword(s):  
Low Dose ◽  
K562 Cells ◽  
Human Leukemia ◽  
Low Dose Radiation ◽  
Radiation Induced ◽  
Induced Apoptosis ◽  
Dose Radiation ◽  
Human Leukemia K562 Cells

An Adoptive Transfer Method to Detect Low-Dose Radiation-Induced Bystander EffectsIn Vivo

2010 ◽  
Vol 173 (2) ◽  
pp. 125-137 ◽  
Author(s):  
Benjamin J. Blyth ◽  
Edouard I. Azzam ◽  
Roger W. Howell ◽  
Rebecca J. Ormsby ◽  
Alexander H. Staudacher ◽  
...  
Keyword(s):  
Adoptive Transfer ◽  
Low Dose ◽  
Low Dose Radiation ◽  
Radiation Induced ◽  
Transfer Method ◽  
Dose Radiation
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