scholarly journals Long-term exposure to polypharmacy impairs cognitive functions in young adult female mice

Aging ◽  
2021 ◽  
Author(s):  
Eroli Francesca ◽  
Johnell Kristina ◽  
Latorre-Leal María ◽  
Hilmer Sarah ◽  
Wastesson Jonas ◽  
...  
2007 ◽  
Vol 53 (5) ◽  
pp. 995-1005 ◽  
Author(s):  
Sukanya JAROENPORN ◽  
Suchinda MALAIVIJITNOND ◽  
Kingkaew WATTANASIRMKIT ◽  
Gen WATANABE ◽  
Kazuyoshi TAYA ◽  
...  

2016 ◽  
Vol 35 (6) ◽  
pp. 645-666 ◽  
Author(s):  
Jinguang Zhang

Previous research found that speakers with more attractive voices receive more favorable evaluations (aka the vocal attractiveness stereotype). But sexual selection theory predicts that, to the extent that men perceive women with higher pitched voices as more attractive, women will be more hostile toward those women because they make more threatening mate rivals. Supporting this hypothesis, Study 1 ( N = 102) showed that female participants higher in trait dominance displayed heightened aggressive cognition after being primed with a romantic (but not a control) feeling and listening to a higher- but not lower-than-average female voice. Study 2 ( N = 111) showed that this heightened aggressive cognition was activated by a long-term but not a short-term mating motive. These findings supported sexual selection theory, challenged the vocal attractiveness stereotype, and suggested a mechanism that helps maintain the honesty of female voice pitch as a mate attraction signal.


2019 ◽  
Vol 90 ◽  
pp. 53-61 ◽  
Author(s):  
Lyda Yuliana Parra-Forero ◽  
Arlet Veloz-Contreras ◽  
Shirley Vargas-Marín ◽  
María Angelica Mojica-Villegas ◽  
Elim Alfaro-Pedraza ◽  
...  

1983 ◽  
Vol 232 (3) ◽  
pp. 625-636 ◽  
Author(s):  
Charles Ruchti ◽  
Denis Haller ◽  
Markus Nuber ◽  
Hans Cottier

2014 ◽  
Vol 1588 ◽  
pp. 55-62 ◽  
Author(s):  
D. Grassi ◽  
N. Lagunas ◽  
I. Calmarza-Font ◽  
Y. Diz-Chaves ◽  
L.M. Garcia-Segura ◽  
...  

2021 ◽  
Vol 9 ◽  
Author(s):  
Christina M. May ◽  
Erik B. Van den Akker ◽  
Bas J. Zwaan

Developmental diet is known to exert long-term effects on adult phenotypes in many animal species as well as disease risk in humans, purportedly mediated through long-term changes in gene expression. However, there are few studies linking developmental diet to adult gene expression. Here, we use a full-factorial design to address how three different larval and adult diets interact to affect gene expression in 1-day-old adult fruit flies (Drosophila melanogaster) of both sexes. We found that the largest contributor to transcriptional variation in young adult flies is larval, and not adult diet, particularly in females. We further characterized gene expression variation by applying weighted gene correlation network analysis (WGCNA) to identify modules of co-expressed genes. In adult female flies, the caloric content of the larval diet associated with two strongly negatively correlated modules, one of which was highly enriched for reproduction-related processes. This suggests that gene expression in young adult female flies is in large part related to investment into reproduction-related processes, and that the level of expression is affected by dietary conditions during development. In males, most modules had expression patterns independent of developmental or adult diet. However, the modules that did correlate with larval and/or adult dietary regimes related primarily to nutrient sensing and metabolic functions, and contained genes highly expressed in the gut and fat body. The gut and fat body are among the most important nutrient sensing tissues, and are also the only tissues known to avoid histolysis during pupation. This suggests that correlations between larval diet and gene expression in male flies may be mediated by the carry-over of these tissues into young adulthood. Our results show that developmental diet can have profound effects on gene expression in early life and warrant future research into how they correlate with actual fitness related traits in early adulthood.


2020 ◽  
Vol 107 (1) ◽  
pp. 31-40
Author(s):  
Anna E. Törnqvist ◽  
Louise Grahnemo ◽  
Karin H. Nilsson ◽  
Thomas Funck-Brentano ◽  
Claes Ohlsson ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document