Chronic unpredictable stress and long-term ovariectomy affect arginine-vasopressin expression in the paraventricular nucleus of adult female mice

2014 ◽  
Vol 1588 ◽  
pp. 55-62 ◽  
Author(s):  
D. Grassi ◽  
N. Lagunas ◽  
I. Calmarza-Font ◽  
Y. Diz-Chaves ◽  
L.M. Garcia-Segura ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Adult Female ◽  
Arginine Vasopressin ◽  
Chronic Unpredictable Stress ◽  
Female Mice

scholarly journals Assessment of Fertility and Reproductive Toxicity in Adult Female Mice after Long-Term Exposure to Pueraria mirifica Herb

2007 ◽  
Vol 53 (5) ◽  
pp. 995-1005 ◽  
Author(s):  
Sukanya JAROENPORN ◽  
Suchinda MALAIVIJITNOND ◽  
Kingkaew WATTANASIRMKIT ◽  
Gen WATANABE ◽  
Kazuyoshi TAYA ◽  
...  
Keyword(s):  
Adult Female ◽  
Reproductive Toxicity ◽  
Pueraria Mirifica ◽  
Female Mice

scholarly journals Long-term exposure to polypharmacy impairs cognitive functions in young adult female mice

Aging ◽  
2021 ◽  
Author(s):  
Eroli Francesca ◽  
Johnell Kristina ◽  
Latorre-Leal María ◽  
Hilmer Sarah ◽  
Wastesson Jonas ◽  
...  
Keyword(s):  
Young Adult ◽  
Adult Female ◽  
Cognitive Functions ◽  
Female Mice

scholarly journals Activation of Glutamate Transporter-1 (GLT-1) Confers Sex-Dependent Neuroprotection in Brain Ischemia

2021 ◽  
Vol 11 (1) ◽  
pp. 76
Author(s):  
Flavia A. Tejeda-Bayron ◽  
David E. Rivera-Aponte ◽  
Christian J. Malpica-Nieves ◽  
Gerónimo Maldonado-Martínez ◽  
Héctor M. Maldonado ◽  
...  
Keyword(s):  
Infarct Size ◽  
Glutamate Transporter ◽  
Triphenyltetrazolium Chloride ◽  
Stroke Outcomes ◽  
Female Mice ◽  
Protein Levels ◽  
Translational Activator ◽  
Glutamate Transporter 1 ◽  
Sensorimotor Performance

Stroke is one of the leading causes of long-term disability. During ischemic stroke, glutamate is released, reuptake processes are impaired, and glutamate promotes excitotoxic neuronal death. Astrocytic glutamate transporter 1 (GLT-1) is the major transporter responsible for removing excess glutamate from the extracellular space. A translational activator of GLT-1, LDN/OSU 0212320 (LDN) has been previously developed with beneficial outcomes in epileptic animal models but has never been tested as a potential therapeutic for ischemic strokes. The present study evaluated the effects of LDN on stroke-associated brain injury. Male and female mice received LDN or vehicle 24 h before or 2 h after focal ischemia was induced in the sensorimotor cortex. Sensorimotor performance was determined using the Rung Ladder Walk and infarct area was assessed using triphenyltetrazolium chloride staining. Males treated with LDN exhibited upregulated GLT-1 protein levels, significantly smaller infarct size, and displayed better sensorimotor performance in comparison to those treated with vehicle only. In contrast, there was no upregulation of GLT-1 protein levels and no difference in infarct size or sensorimotor performance between vehicle- and LDN-treated females. Taken together, our results indicate that the GLT-1 translational activator LDN improved stroke outcomes in young adult male, but not female mice.

Norepinephrine regulates arginine vasopressin secretion in hypothalamic paraventricular nucleus relating with pain modulation

Neuropeptides ◽  
2009 ◽  
Vol 43 (4) ◽  
pp. 259-265 ◽  
Author(s):  
Jun Yang ◽  
Hui-Feng Yuan ◽  
Wen-Yan Liu ◽  
Xiao-Xia Zhang ◽  
Jian-Peng Feng ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Arginine Vasopressin ◽  
Pain Modulation ◽  
Hypothalamic Paraventricular Nucleus ◽  
Vasopressin Secretion
Sign in / Sign up

Export Citation Format

Share Document