scholarly journals Resveratrol improves Gly-LDL-induced vascular endothelial cell apoptosis, inflammatory factor secretion and oxidative stress by regulating miR-142-3p and regulating SPRED2-mediated autophagy

Aging ◽  
2021 ◽  
Author(s):  
Wenjun Sha ◽  
Meizhi Liu ◽  
Dusang Sun ◽  
Junhui Qiu ◽  
Bilin Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Inflammatory Factor ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis ◽  
And Oxidative Stress ◽  
Factor Secretion

scholarly journals Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion

2018 ◽  
Vol 38 (3) ◽  
Author(s):  
Chengfu Song ◽  
Xiangdong Zhao
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Artery Occlusion ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis ◽  
Related Factors ◽  
Cerebral Artery Occlusion

In patients with cerebral infarction (CI), elevated serum uric acid (UA) level may exacerbate the occurrence and development of carotid atherosclerosis (AS). Our study intended to explore the underlying mechanism. We enrolled 86 patients with CI, and divided them into four groups: Non-AS, AS-mild, AS-moderate, and AS-severe groups; the levels of UA and oxidative stress-related factors in serum were detected. The middle cerebral artery occlusion (MCAO) model was used to stimulate CI in rats, and different doses of UA were administrated. The levels of oxidative stress-related factors in serum were detected. Hematoxylin & eosin (H&E) staining was used to observe the morphological alterations, and the apoptotic cell death detection kit was used to detect apoptotic cells. Increased UA concentration and enhanced oxidative stress were found in AS patients. H&E staining results showed that UA treatment exacerbated morphological damage in rats with MCAO, promoted oxidative stress, and enhanced vascular endothelial cell apoptosis in rats with MCAO.

scholarly journals Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling

2021 ◽  
Vol 22 (19) ◽  
pp. 10309
Author(s):  
Chen-Sheng Chen ◽  
Bo-Yi Pan ◽  
Ping-Hsuan Tsai ◽  
Fang-Yu Chen ◽  
Wen-Chin Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Vascular Endothelial ◽  
Oxygen Species ◽  
Endothelial Cell Apoptosis ◽  
Atherosclerosis Development ◽  
Oil Red O Staining ◽  
Oil Red O

Reactive oxygen species (ROS)-induced vascular endothelial cell apoptosis is strongly associated with atherosclerosis progression. Herein, we aimed to examine whether Kansuinine A (KA), extracted from Euphorbia kansui L., prevents atherosclerosis development in a mouse model and inhibits cell apoptosis through oxidative stress reduction. Atherosclerosis development was analyzed in apolipoprotein E-deficient (ApoE−/−) mice fed a high-fat diet (HFD) using Oil Red O staining and H&E staining. Human aortic endothelial cells (HAECs) were treated with KA, followed by hydrogen peroxide (H2O2), to investigate the KA-mediated inhibition of ROS-induced oxidative stress and cell apoptosis. Oil Red O staining and H&E staining showed that atherosclerotic lesion size was significantly smaller in the aortic arch of ApoE−/− mice in the HFD+KA group than that in the aortic arch of those in the HFD group. Further, KA (0.1–1.0 μM) blocked the H2O2-induced death of HAECs and ROS generation. The H2O2-mediated upregulation of phosphorylated IKKβ, phosphorylated IκBα, and phosphorylated NF-κB was suppressed by KA. KA also reduced the Bax/Bcl-2 ratio and cleaved caspase-3 expression, preventing H2O2-induced vascular endothelial cell apoptosis. Our results indicate that KA may protect against ROS-induced endothelial cell apoptosis and has considerable clinical potential in the prevention of atherosclerosis and cardiovascular diseases.

Crocetin prevents AGEs-induced vascular endothelial cell apoptosis

2006 ◽  
Vol 54 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Min Xiang ◽  
Min Yang ◽  
Chenghua Zhou ◽  
Juan Liu ◽  
Wenna Li ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis

scholarly journals Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis

2000 ◽  
Vol 35 (7) ◽  
pp. 1785-1790 ◽  
Author(s):  
Atsushi Iwakura ◽  
Masatoshi Fujita ◽  
Koji Hasegawa ◽  
Tatsuya Sawamura ◽  
Ryuji Nohara ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Unstable Angina ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Pericardial Fluid ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis
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