scholarly journals Association of D-dimer elevation with inflammation and organ dysfunction in ICU patients with COVID-19 in Wuhan, China: a retrospective observational study

Aging ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 4794-4810
Author(s):  
Wang Zhang ◽  
Ling Sang ◽  
Jiaran Shi ◽  
Ming Zhong ◽  
Li Jiang ◽  
...  
Keyword(s):  
Observational Study ◽  
Organ Dysfunction ◽  
Retrospective Observational Study ◽  
Icu Patients ◽  
D Dimer

Prognostic value of serum galactomannan in mixed ICU patients: a retrospective observational study

2014 ◽  
Vol 46 (3) ◽  
pp. 145-154 ◽  
Author(s):  
Suzanne Teering ◽  
Annelies Verreth ◽  
Anneleen Peeters ◽  
Niels Van Regenmortel ◽  
Inneke De Laet ◽  
...  
Keyword(s):  
Observational Study ◽  
Prognostic Value ◽  
Retrospective Observational Study ◽  
Icu Patients

scholarly journals Acute kidney injury in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study

2020 ◽  
Author(s):  
Guanhua Xiao ◽  
Hongbin Hu ◽  
Feng Wu ◽  
Tong Sha ◽  
Qiaobing Huang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Observational Study ◽  
White Blood Cells ◽  
Protein A ◽  
Kidney Injury ◽  
Retrospective Observational Study ◽  
Single Center ◽  
Logistic Regression Models ◽  
Computed Tomographic ◽  
D Dimer

AbstractBackgroundThe kidney may be affected in coronavirus-2019 disease (COVID-19). This study assessed the predictors and outcomes of acute kidney injury (AKI) among individuals with COVID-19.MethodsThis observational study, included data on all patients with clinically confirmed COVID-19 admitted to Hankou Hospital, Wuhan, China from January 5 to March 8, 2020. Data were extracted from clinical and laboratory records. Follow-up was censored on March 8, 2020.This is a single-center, retrospective, observational study. Patients clinically confirmed COVID-19 and admitted to Hankou Hospital, Wuhan, China from January 5 to March 8, 2020 were enrolled. We evaluated the association between changes in the incidence of AKI and COVID-19 disease and clinical outcomes by using logistic regression models.ResultsA total of 287 patients, 55 with AKI and 232 without AKI, were included in the analysis. Compared to patients without AKI, AKI patients were older, predominantly male, and were more likely to present with hypoxia and have pre-existing hypertension and cerebrovascular disease. Moreover, AKI patients had higher levels of white blood cells, D-dimer, aspartate aminotransferase, total bilirubin, creatine kinase, lactate dehydrogenase, procalcitonin, C-reactive protein, a higher prevalence of hyperkalemia, lower lymphocyte counts, and higher chest computed tomographic scores. The incidence of stage 1 AKI was 14.3%, and the incidence of stage 2 or 3 AKI was 4.9%. Patients with AKI had substantially higher mortality.ConclusionsAKI is an important complication of COVID-19. Older age, male, multiple pre-existing comorbidities, lymphopenia, increased infection indicators, elevated D-dimer, and impaired heart and liver functions were the risk factors of AKI. AKI patients who progressed to stages 2 or 3 AKI had a higher mortality rate. Prevention of AKI and monitoring of kidney function is very important for COVID-19 patients.Trial registrationNCT04316299(03/19/2020)

scholarly journals Prognostic value of serum galactomannan in mixed ICU patients: a retrospective observational study

Critical Care ◽  
2012 ◽  
Vol 16 (S1) ◽  
Author(s):  
S Teering ◽  
A Verreth ◽  
W Verlinden ◽  
J Jacobs ◽  
S Pilate ◽  
...  
Keyword(s):  
Observational Study ◽  
Prognostic Value ◽  
Retrospective Observational Study ◽  
Icu Patients

scholarly journals Predictors of COVID-19 Mortality in Critically Ill ICU Patients: A Multicenter Retrospective Observational Study

Cureus ◽  
2022 ◽  
Author(s):  
Chukwuemeka Umeh ◽  
Laura Tuscher ◽  
Sobiga Ranchithan ◽  
Kimberly Watanabe ◽  
Rahul Gupta
Keyword(s):  
Observational Study ◽  
Critically Ill ◽  
Retrospective Observational Study ◽  
Icu Patients

scholarly journals Neuroimaging Findings of Hospitalized Covid-19 Patients: A Canadian Retrospective Observational Study

2021 ◽  
pp. 084653712110028
Author(s):  
Vibeeshan Jegatheeswaran ◽  
Michael W. K. Chan ◽  
Sumon Chakrabarti ◽  
Adrian Fawcett ◽  
Yingming Amy Chen
Keyword(s):  
Observational Study ◽  
Clinical Status ◽  
Tertiary Care ◽  
Case Series ◽  
Tertiary Hospital ◽  
Adult Patients ◽  
Retrospective Observational Study ◽  
Acute Ischemia ◽  
Care Hospital ◽  
Icu Patients

Purpose: Coronavirus disease (COVID-19) has been associated with neurologic sequelae and neuroimaging abnormalities in several case series previously. In this study, the neuroimaging findings and clinical course of adult patients admitted with COVID-19 to a tertiary care hospital network in Canada were characterized. Methods: This is a retrospective observational study conducted at a tertiary hospital network in Ontario, Canada. All adult patients with PCR-confirmed COVID-19 admitted from February 1, 2020 to July 22, 2020 who received neuroimaging related to their COVID-19 admission were included. CT and MR images were reviewed and categorized by fellowship-trained neuroradiologists. Demographic and clinical data were collected and correlated with imaging findings. Results: We identified 422 patients admitted with COVID-19 during the study period. 103 (24.4%) met the inclusion criteria and were included: 30 ICU patients (29.1%) and 73 non-ICU patients (70.9%). A total of 198 neuroimaging studies were performed: 177 CTs and 21 MRIs. 17 out of 103 imaged patients (16.8%) had acute abnormalities on neuroimaging: 10 had macrohemorrhages (58.8%), 9 had acute ischemia (52.9%), 4 had SWI abnormalities (23.5%), and 1 had asymmetric sulcal effacement suggesting possible focal encephalitis (5.8%). ICU patients were more likely to have positive neuroimaging findings, more specifically acute ischemia and macrohemorrhages ( P < 0.05). Macrohemorrhages were associated with increased mortality ( P < 0.05). Conclusion: Macrohemorrhages, acute ischemia and SWI abnormalities were the main neuroimaging abnormalities in our cohort of hospitalized COVID-19 patients. Acute ischemia and hemorrhage were associated with worse clinical status.

Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Frequent Change ◽  
Patient Age ◽  
Treatment Regimens ◽  
Patient Âgé ◽  
The Relationship ◽  
Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

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