scholarly journals KCNN4 is a diagnostic and prognostic biomarker that promotes papillary thyroid cancer progression

Aging ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 16437-16456
Author(s):  
Jialiang Wen ◽  
Bangyi Lin ◽  
Lizhi Lin ◽  
Yizuo Chen ◽  
Ouchen Wang
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Progression ◽  
Prognostic Biomarker ◽  
Papillary Thyroid

scholarly journals MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Lei Dai ◽  
Yaozong Wang ◽  
Liangliang Chen ◽  
Jueru Zheng ◽  
Jianjun Li ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Prognostic Biomarker ◽  
Papillary Thyroid

scholarly journals LncRNA LINC00460 promotes the papillary thyroid cancer progression by regulating the LINC00460/miR-485-5p/Raf1 axis

2019 ◽  
Vol 52 (1) ◽  
Author(s):  
Guangjun Li ◽  
Qingli Kong
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Progression ◽  
Binding Sites ◽  
Luciferase Reporter ◽  
Reporter Assay ◽  
Papillary Thyroid ◽  
Potential Biomarker ◽  
Common Malignancy

Abstract Background Papillary thyroid cancer (PTC) is the most common malignancy of all thyroid cancers. LncRNA LINC00460 has been proved to play roles in the oncogenesis and progression of various tumors, including papillary thyroid cancer. However, the potential molecular mechanism of LINC00460 in PTC is poorly investigated. Results LINC00460 was upregulated in PTC tissues and cells. Raf1 was upregulated in PTC tissues, but miR-485-5p was down-regulated. High LINC00460 expression was associated with poor prognosis. LINC00460 knockdown suppressed proliferation, migration, invation and EMT of PTC cells. Bioinformatics prediction revealed that LINC00460 had binding sites with miR-485-5p, which was validated by luciferase reporter assay. In addition, miR-485-5p was confirmed to directly target Raf1 3′-UTR. Moreover, LINC00460 promoted PTC progression by sponging miR-485-5p to elevate the expression of Raf1. Knockdown of LINC00460 restrained tumor growth in vivo. Conclusion LINC00460 induced proliferation, migration, invation and EMT of PTC cells by regulating the LINC00460/miR-485-5p/Raf1 axis, which indicated that LINC00460 may be a potential biomarker and therapeutic target for PTC.

scholarly journals MFAP2 is a Potential Diagnostic and Prognostic Biomarker That Correlates with the Progression of Papillary Thyroid Cancer

2020 ◽  
Vol Volume 12 ◽  
pp. 12557-12567
Author(s):  
Si Yang Dong ◽  
Hao Chen ◽  
Li Zhi Lin ◽  
Lingli Jin ◽  
Dan Xiang Chen ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Prognostic Biomarker ◽  
Papillary Thyroid

scholarly journals Mouse Models of Follicular and Papillary Thyroid Cancer Progression

2012 ◽  
Vol 2 ◽  
Author(s):  
Marika A. Russo ◽  
Valeria G. Antico Arciuch ◽  
Antonio Di Cristofano
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Mouse Models ◽  
Cancer Progression ◽  
Papillary Thyroid
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