scholarly journals Interleukin-6 -174 G/C polymorphism is associated with the risk of basal cell carcinoma in a Chinese Han population

Aging ◽  
2020 ◽  
Vol 12 (15) ◽  
pp. 15328-15333
Author(s):  
Jing Wang ◽  
Yi Chen
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Interleukin 6 ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Associations between polymorphisms in the IL-4 gene and renal cell carcinoma in Chinese Han population

Oncotarget ◽  
2017 ◽  
Vol 8 (47) ◽  
pp. 82078-82084
Author(s):  
Hao Rong ◽  
Xue He ◽  
Li Wang ◽  
Yongjun He ◽  
Longli Kang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Chongwen Xu ◽  
Peng Han ◽  
Wanli Ren ◽  
Hao Dai ◽  
Yanxia Bai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Protective Role ◽  
Neck Squamous Cell Carcinoma ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Purpose. Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. Methods. We recruited 537 HNSCC cases and 533 healthy subjects to detect the correlation of six polymorphisms in MIR17HG with HNSCC susceptibility. The associations were evaluated by computing odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. Results. Our study revealed that rs7336610 (OR 1.77, 95 % CI = 1.09 ‐ 2.86 , and p = 0.021 ) and rs1428 (OR 1.73, 95 % CI = 1.07 ‐ 2.81 , and p = 0.025 ) are strongly associated with increased susceptibility to HNSCC in men. Besides, rs17735387 played a crucial protective role in stage III/IV HNSCC patients (OR 0.34, 95 % CI = 0.12 ‐ 0.95 , and p = 0.040 ) compared with stage I/II. Conclusion. Our study firstly indicated that MIR17HG polymorphisms are significantly associated with HNSCC susceptibility, which suggests that MIR17HG has a potential role in the occurrence of HNSCC.

scholarly journals Association of Polymorphisms in X-Ray Repair Cross Complementing 1 Gene and Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Yu-Xia Yun ◽  
Li-Ping Dai ◽  
Peng Wang ◽  
Kai-Juan Wang ◽  
Jian-Ying Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chinese Population ◽  
Haplotype Analysis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
X Ray

Objectives. To investigate the association between three single nucleotide polymorphisms (SNPs) in the X-ray repair cross complementing 1 gene (XRCC1) and the risk of esophageal squamous cell carcinoma (ESCC) in Chinese population.Methods. A case-control study including 381 primary ESCC patients recruited from hospital and 432 normal controls matched with patients by age and gender from Chinese Han population was conducted. The genotypes of threeXRCC1polymorphisms at −77T>C (T-77C), codon 194 (Arg194Trp), and codon 399 (Arg399Gln) were studied by means of polymerase chain reaction-restriction fragment length polymorphism techniques (PCR-RFLP). Unconditional logistic regression model and haplotype analysis were used to estimate associations of these three SNPs inXRCC1gene with ESCC risk.Results. Polymorphisms at these three sites inXRCC1gene were not found to be associated with risk for developing ESCC; however the haplotypeCcodon 194Gcodon 399C-77T>Cwas significantly associated with reduced risk of ESCC (OR: 0.62, 95% CI: 0.40–0.96) upon haplotype analysis.Conclusion. These results suggested that the gene-gene interactions might play vital roles in the progression on esophageal cancer in Chinese Han population and it would be necessary to confirm these findings in a large and multiethnic population.

Identification of interleukin-6 promoter polymorphisms in the Chinese Han population and their functional significance*

2008 ◽  
Vol 36 (5) ◽  
pp. 1437-1443 ◽  
Author(s):  
Wei Gu ◽  
Ding-yuan Du ◽  
Jian Huang ◽  
Lian-yang Zhang ◽  
Qin Liu ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Functional Significance ◽  
Chinese Han Population ◽  
Promoter Polymorphisms ◽  
Chinese Han ◽  
Han Population
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