E6 and E7 of human papillomavirus type 18 and UVB irradiation corporately regulate interleukin-6 and interleukin-8 expressions in basal cell carcinoma

2013 ◽  
Vol 22 (10) ◽  
pp. 672-674 ◽  
Author(s):  
Yu-Ping Hsiao ◽  
Jen-Hung Yang ◽  
Wen-Jun Wu ◽  
Meng-Hsuan Lin ◽  
Gwo-Tarng Sheu
Keyword(s):  
Human Papillomavirus ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Interleukin 6 ◽  
Interleukin 8 ◽  
Uvb Irradiation ◽  
E6 And E7

scholarly journals Case–Control Study of Cutaneous Human Papillomavirus Infection in Basal Cell Carcinoma of the Skin

2013 ◽  
Vol 133 (6) ◽  
pp. 1512-1520 ◽  
Author(s):  
Michelle R. Iannacone ◽  
Tarik Gheit ◽  
Tim Waterboer ◽  
Anna R. Giuliano ◽  
Jane L. Messina ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Case Control Study ◽  
Case Control ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Control Study

scholarly journals Overexpression of interleukin-6 in human basal cell carcinoma cell lines increases anti-apoptotic activity and tumorigenic potency

Oncogene ◽  
2001 ◽  
Vol 20 (2) ◽  
pp. 198-208 ◽  
Author(s):  
Shiou-Hwa Jee ◽  
Shing-Chuan Shen ◽  
Hsien-Ching Chiu ◽  
Wei-Ling Tsai ◽  
Min-Liang Kuo
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Basal Cell ◽  
Interleukin 6 ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Apoptotic Activity ◽  
Human Basal Cell Carcinoma

Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells

2012 ◽  
Vol 258 (2) ◽  
pp. 199-207 ◽  
Author(s):  
Li-Wen Huang ◽  
Bau-Shan Hsieh ◽  
Hsiao-Ling Cheng ◽  
Yu-Chen Hu ◽  
Wen-Tsan Chang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Cycle Arrest ◽  
Basal Cell ◽  
Interleukin 6 ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
Human Basal Cell Carcinoma

scholarly journals The role of protein-53 amyloid in determining the aggressiveness of basal cell carcinoma regulated by interleukin-6, myeloid cell leukemia-1 and basic fibroblast growth factor

2019 ◽  
Author(s):  
Prasetyadi Mawardi ◽  
Handono Kalim ◽  
Kusworini Handono Kalim ◽  
Loeki Enggar Fitri ◽  
Karyono Mintarjo ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Interleukin 6 ◽  
Myeloid Cell ◽  
Amyloid Deposit ◽  
Skin Tumor ◽  
Amyloid Deposits ◽  
Significant Difference ◽  
Malignant Skin

Basal cell carcinoma (BCC) is a common malignant skin tumor that rarely metastasized, although it is often locally destructive and aggressive. The amyloid in BCC is resulted from degenerated epithelial cell through apoptosis caused by activation of p53. Interleukin-6, MCL-1 and bFGF are inflammatory mediators which have important role in angiogenesis. To prove that high expression of p53 amyloid is related to aggressiveness of BCC via the regulation of IL-6, MCL-1 and bFGF expression. Archived specimens from 51 cases diagnosed with Primary BCC. We performed immunohistochemical staining for IL-6, MCL-1, bFGF expression and p53 amyloid deposit. There was a significant difference in the expression of p53 (p = 0.04), amyloid deposits (p = 0.015), P53 amyloid deposits (p = 0.038), IL-6 (p = 0.040), MCL-1 (p = 0.032), bFGF (p = 0.044) in A BCC compared with NA BCC. There were a significant association between MCL-1 and bFGF (p = 0.07) and p53 amyloid with bFGF (p = 0.051). p53 amyloid, IL-6, MCL-1 and bFGF have an important role in BCC aggresivity.

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