scholarly journals Soy isoflavones improve the oxidative stress induced hypothalamic inflammation and apoptosis in high fat diet-induced obese male mice through PGC1-alpha pathway

Aging ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 8710-8727 ◽  
Author(s):  
Dejiang Pang ◽  
Chengcheng Yang ◽  
Qihui Luo ◽  
Chao Li ◽  
Wentao Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Soy Isoflavones ◽  
Male Mice ◽  
High Fat ◽  
Hypothalamic Inflammation ◽  
Obese Male

scholarly journals Anti-Obesity Effects of Combined Cornus officinalis and Ribes fasciculatum Extract in High-Fat Diet-Induced Obese Male Mice

Animals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3187
Author(s):  
Eunkuk Park ◽  
Chang-Gun Lee ◽  
Hyoju Jeon ◽  
Hyesoo Jeong ◽  
Subin Yeo ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Insulin Action ◽  
Normal Diet ◽  
Male Mice ◽  
Impaired Glucose Metabolism ◽  
High Fat ◽  
Beneficial Effects ◽  
Cornus Officinalis ◽  
Treatment And Prevention ◽  
Obese Male

Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of Cornus officinalis and Ribes fasciculatum (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.

scholarly journals GABA Type B Receptor Signaling in Proopiomelanocortin Neurons Protects Against Obesity, Insulin Resistance, and Hypothalamic Inflammation in Male Mice on a High-Fat Diet

2013 ◽  
Vol 33 (43) ◽  
pp. 17166-17173 ◽  
Author(s):  
Yoshihiro Ito ◽  
Ryoichi Banno ◽  
Miyuki Shibata ◽  
Koichi Adachi ◽  
Shigeru Hagimoto ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Fat Diet ◽  
Receptor Signaling ◽  
Male Mice ◽  
Type B ◽  
High Fat ◽  
Hypothalamic Inflammation

scholarly journals Chronic rhein treatment improves recognition memory in high-fat diet-induced obese male mice

2016 ◽  
Vol 36 ◽  
pp. 42-50 ◽  
Author(s):  
Sen Wang ◽  
Xu-Feng Huang ◽  
Peng Zhang ◽  
Hongqin Wang ◽  
Qingsheng Zhang ◽  
...  
Keyword(s):  
Recognition Memory ◽  
High Fat Diet ◽  
Male Mice ◽  
High Fat ◽  
Obese Male

Ursolic acid induces white adipose tissue beiging in high-fat-diet obese male mice

2021 ◽  
Author(s):  
Ao Sun ◽  
Xiaoqin Hu ◽  
Huijian Chen ◽  
Yulan Ma ◽  
Xiyue Yan ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Ursolic Acid ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
Signal Pathway ◽  
Male Mice ◽  
High Fat ◽  
Obese Male

Ursolic acid increases the secretion of irisin by the PRDM16–PGC-1α–FNDC5 signal pathway to induce beiging of WAT and improve obese conditions.

scholarly journals The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice

2020 ◽  
Vol 36 ◽  
pp. 100979
Author(s):  
Isabel Martinez-Pena y Valenzuela ◽  
Mohammed Akaaboune
Keyword(s):  
High Fat Diet ◽  
Neuromuscular Synapse ◽  
Male Mice ◽  
High Fat ◽  
Obese Male

scholarly journals Anthocyanins from black wolfberry (Lycium ruthenicum Murr.) prevent inflammation and increase fecal fatty acid in diet-induced obese rats

RSC Advances ◽  
2017 ◽  
Vol 7 (75) ◽  
pp. 47848-47853 ◽  
Author(s):  
Jinjin Yin ◽  
Tao Wu
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid ◽  
High Fat Diet ◽  
Sprague Dawley ◽  
High Fat ◽  
Sprague Dawley Rats ◽  
Lycium Ruthenicum ◽  
Obese Rats ◽  
Lycium Ruthenicum Murr ◽  
Obese Male

This study aimed to determine whether black wolfberry (Lycium ruthenicumMurr.) anthocyanin (BWA) consumption can alleviate oxidative stress and reduce inflammation in high-fat diet-induced obese male Sprague-Dawley rats.

scholarly journals Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high‐fat diet

Aging Cell ◽  
2014 ◽  
Vol 13 (4) ◽  
pp. 616-622 ◽  
Author(s):  
Olga V. Leontieva ◽  
Geraldine M. Paszkiewicz ◽  
Mikhail V. Blagosklonny
Keyword(s):  
High Fat Diet ◽  
Male Mice ◽  
High Fat ◽  
Weekly Administration ◽  
Obese Male

scholarly journals Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Jifeng Ye ◽  
Dandan Luo ◽  
Xiaolin Xu ◽  
Mingqi Sun ◽  
Xiaohui Su ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
High Fat Diet ◽  
Male Fertility ◽  
Underlying Mechanism ◽  
High Fat ◽  
Metabolic Disturbances ◽  
Related Proteins ◽  
Obese Male ◽  
Blood Testis Barrier

Background/Aims. Obesity, which is related to increased oxidative stress in various tissues, is a risk factor for male infertility. Metformin is reported to have an antioxidant effect; however, the precise role of metformin in obesity-induced male infertility remains unknown. The current study is aimed at exploring the effects of metformin and characterizing its underlying mechanism in the fertility of obese males. Methods. An obese male mouse model was generated by feeding mice with a high-fat diet; then, the mice were administered metformin in water for 8 weeks. Reproductive ability, metabolic parameters, and follicle-stimulating hormone (FSH) were assessed by cohabitation, enzymatic methods, and ELISA, respectively. Damage to the integrity of the blood-testis barrier (BTB), which ensures spermatogenesis, was assessed by transmission electron microscopy and immunofluorescence with a biotin tracer. Malondialdehyde (MDA), superoxide dismutase (SOD), and reactive oxygen species (ROS) were employed for the assessments of oxidative stress. BTB-related proteins were measured by immunoblotting. Nuclear factor κB (NF-κB) was assessed by immunofluorescence. Results. High-fat-diet-fed mice presented evident lipid metabolic disturbances, disrupted BTB integrity, and decreased reproductive function. Metformin alleviated the decrease in male fertility, decreased ectopic lipid deposition in the testis, and increased serum FSH levels. A further mechanistic analysis revealed that metformin ameliorated the high-fat-diet-induced injury to the BTB structure and permeability and restored the disordered BTB-related proteins, which might be associated with an improvement in oxidative stress and a recovery of NF-κB activity in Sertoli cells (SCs). Conclusion. Metformin improves obese male fertility by alleviating oxidative stress-induced BTB damage. These findings provide new insights into the effect of metformin on various diseases and suggest future possibilities in the treatment of male infertility.

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