scholarly journals Cutaneous wound healing in aged, high fat diet-induced obese female or male C57BL/6 mice

Aging ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 7066-7111 ◽  
Author(s):  
Marta Kopcewicz ◽  
Katarzyna Walendzik ◽  
Joanna Bukowska ◽  
Anna Kur-Piotrowska ◽  
Sylwia Machcinska ◽  
...  
Keyword(s):  
Wound Healing ◽  
High Fat Diet ◽  
Cutaneous Wound Healing ◽  
High Fat ◽  
Cutaneous Wound ◽  
Obese Female

scholarly journals Overweight induced by high-fat diet delays rat cutaneous wound healing

2006 ◽  
Vol 96 (6) ◽  
pp. 1069-1077 ◽  
Author(s):  
Adriana P. Nascimento ◽  
Andréa M. A. Costa
Keyword(s):  
Blood Pressure ◽  
Wound Healing ◽  
High Fat Diet ◽  
Inflammatory Infiltrate ◽  
Cellular Proliferation ◽  
Chronic Wounds ◽  
Wound Contraction ◽  
Cutaneous Wound Healing ◽  
High Fat ◽  
Cutaneous Wound

Prolonged wound healing is a complication that contributes to morbidity and mortality. Overweight people regularly undergo surgery and trauma, and often develop chronic wounds, but the effects of the adipose tissue excess on cutaneous wound healing are not well understood. This study tested the hypothesis that overweight induced by a high-fat diet impairs rat cutaneous wound healing. Male Wistar rats were fed with either a high-fat or a standard (control) diet. After 15 weeks, an excisional lesion was done and the animals were killed 21 d later. Wound contraction and re-epithelialization, blood pressure, glucose and retroperitoneal fat were evaluated. After killing, lesion and adjacent normal skin were formol-fixed and paraffin-embedded. Inflammatory infiltrate, myofibroblasts, collagen fibres and cellular proliferation were analysed and blood vessels were evaluated using stereological methods. There was no difference in blood pressure and glucose, but retroperitoneal fat increased in the high-fat diet group. Animals fed with the high-fat diet presented delayed wound contraction and re-epithelialization. It was found that 21 d after wounding, overweight induced by a high-fat diet increased the inflammatory infiltrate and delayed myofibroblastic differentiation, collagen deposition, epithelial and connective tissue cell proliferation, and angiogenesis. These findings support the hypothesis that a high-fat diet exerts negative effects on rat cutaneous wound healing, due mainly to the prolongation of the inflammatory phase.

Exercise Speeds Cutaneous Wound Healing in High-Fat Diet-Induced Obese Mice

2012 ◽  
Vol 44 (10) ◽  
pp. 1846-1854 ◽  
Author(s):  
BRANDT D. PENCE ◽  
LUISA A. DIPIETRO ◽  
JEFFREY A. WOODS
Keyword(s):  
Wound Healing ◽  
High Fat Diet ◽  
Cutaneous Wound Healing ◽  
Obese Mice ◽  
High Fat ◽  
Cutaneous Wound

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

scholarly journals Optical coherence tomography angiography monitors human cutaneous wound healing over time

2018 ◽  
Vol 8 (2) ◽  
pp. 135-150 ◽  
Author(s):  
Anthony J. Deegan ◽  
Wendy Wang ◽  
Shaojie Men ◽  
Yuandong Li ◽  
Shaozhen Song ◽  
...  
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Over Time

Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing

2021 ◽  
Vol 122 ◽  
pp. 199-210
Author(s):  
Chen Wang ◽  
Guoyun Li ◽  
Kaige Cui ◽  
Zihan Chai ◽  
Ziyu Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound
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