Combined Mulberry Leaf and Fruit Extract Improved Early Stage of Cutaneous Wound Healing in High-Fat Diet-Induced Obese Mice

2016 ◽  
Vol 19 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Hyeyoon Eo ◽  
Yunsook Lim
Keyword(s):  
Wound Healing ◽  
High Fat Diet ◽  
Early Stage ◽  
Cutaneous Wound Healing ◽  
Obese Mice ◽  
High Fat ◽  
Fruit Extract ◽  
Cutaneous Wound ◽  
Mulberry Leaf

Exercise Speeds Cutaneous Wound Healing in High-Fat Diet-Induced Obese Mice

2012 ◽  
Vol 44 (10) ◽  
pp. 1846-1854 ◽  
Author(s):  
BRANDT D. PENCE ◽  
LUISA A. DIPIETRO ◽  
JEFFREY A. WOODS
Keyword(s):  
Wound Healing ◽  
High Fat Diet ◽  
Cutaneous Wound Healing ◽  
Obese Mice ◽  
High Fat ◽  
Cutaneous Wound

scholarly journals Overweight induced by high-fat diet delays rat cutaneous wound healing

2006 ◽  
Vol 96 (6) ◽  
pp. 1069-1077 ◽  
Author(s):  
Adriana P. Nascimento ◽  
Andréa M. A. Costa
Keyword(s):  
Blood Pressure ◽  
Wound Healing ◽  
High Fat Diet ◽  
Inflammatory Infiltrate ◽  
Cellular Proliferation ◽  
Chronic Wounds ◽  
Wound Contraction ◽  
Cutaneous Wound Healing ◽  
High Fat ◽  
Cutaneous Wound

Prolonged wound healing is a complication that contributes to morbidity and mortality. Overweight people regularly undergo surgery and trauma, and often develop chronic wounds, but the effects of the adipose tissue excess on cutaneous wound healing are not well understood. This study tested the hypothesis that overweight induced by a high-fat diet impairs rat cutaneous wound healing. Male Wistar rats were fed with either a high-fat or a standard (control) diet. After 15 weeks, an excisional lesion was done and the animals were killed 21 d later. Wound contraction and re-epithelialization, blood pressure, glucose and retroperitoneal fat were evaluated. After killing, lesion and adjacent normal skin were formol-fixed and paraffin-embedded. Inflammatory infiltrate, myofibroblasts, collagen fibres and cellular proliferation were analysed and blood vessels were evaluated using stereological methods. There was no difference in blood pressure and glucose, but retroperitoneal fat increased in the high-fat diet group. Animals fed with the high-fat diet presented delayed wound contraction and re-epithelialization. It was found that 21 d after wounding, overweight induced by a high-fat diet increased the inflammatory infiltrate and delayed myofibroblastic differentiation, collagen deposition, epithelial and connective tissue cell proliferation, and angiogenesis. These findings support the hypothesis that a high-fat diet exerts negative effects on rat cutaneous wound healing, due mainly to the prolongation of the inflammatory phase.

scholarly journals Cutaneous wound healing in aged, high fat diet-induced obese female or male C57BL/6 mice

Aging ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 7066-7111 ◽  
Author(s):  
Marta Kopcewicz ◽  
Katarzyna Walendzik ◽  
Joanna Bukowska ◽  
Anna Kur-Piotrowska ◽  
Sylwia Machcinska ◽  
...  
Keyword(s):  
Wound Healing ◽  
High Fat Diet ◽  
Cutaneous Wound Healing ◽  
High Fat ◽  
Cutaneous Wound ◽  
Obese Female

scholarly journals Effect of combined mulberry leaf and fruit extract on liver and skin cholesterol transporters in high fat diet-induced obese mice

2014 ◽  
Vol 8 (1) ◽  
pp. 20 ◽  
Author(s):  
Giuseppe Valacchi ◽  
Giuseppe Belmonte ◽  
Clelia Miracco ◽  
Hyeyoon Eo ◽  
Yunsook Lim
Keyword(s):  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Fruit Extract ◽  
Mulberry Leaf ◽  
Cholesterol Transporters

scholarly journals Effect of Dietary Conjugated Linoleic Acid Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Na-Young Park ◽  
Giuseppe Valacchi ◽  
Yunsook Lim
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Wound Closure ◽  
Inflammatory Responses ◽  
Early Stage ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Anti Inflammatory

Inflammatory response is considered the most important period that regulates the entire healing process. Conjugated linoleic acid (CLA), a class of linoleic acid positional and geometric isomers, is well known for its antioxidant and anti-inflammatory properties. We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. Mice fed dietary CLA supplementation had reduced levels of oxidative stress and inflammatory markers. Moreover, the wound closure rate was improved significantly in mice fed a 1% CLA-supplemented diet during early stage of wound healing (inflammatory stage). We conclude that dietary CLA supplementation enhances the early stage of cutaneous wound healing as a result of modulating oxidative stress and inflammatory responses.

scholarly journals Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Li Hu ◽  
Juan Wang ◽  
Xin Zhou ◽  
Zehuan Xiong ◽  
Jiajia Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Early Stage ◽  
Mouse Skin ◽  
Scar Formation ◽  
Collagen I ◽  
Dependent Manner ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

Abstract Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we investigated the roles of ASCs-derived exosomes (ASCs-Exos) in cutaneous wound healing. We found that ASCs-Exos could be taken up and internalized by fibroblasts to stimulate cell migration, proliferation and collagen synthesis in a dose-dependent manner, with increased genes expression of N-cadherin, cyclin-1, PCNA and collagen I, III. In vivo tracing experiments demonstrated that ASCs-Exos can be recruited to soft tissue wound area in a mouse skin incision model and significantly accelerated cutaneous wound healing. Histological analysis showed increased collagen I and III production by systemic administration of exosomes in the early stage of wound healing, while in the late stage, exosomes might inhibit collagen expression to reduce scar formation. Collectively, our findings indicate that ASCs-Exos can facilitate cutaneous wound healing via optimizing the characteristics of fibroblasts. Our results provide a new perspective and therapeutic strategy for the use of ASCs-Exos in soft tissue repair.

Laser phototherapy improves early stage of cutaneous wound healing of rats under hyperlipidic diet

2016 ◽  
Vol 31 (7) ◽  
pp. 1363-1370 ◽  
Author(s):  
Virgínia Dias Uzêda-e-Silva ◽  
Tania Tavares Rodriguez ◽  
Isadora Almeida Rios Rocha ◽  
Flávia Calo Aquino Xavier ◽  
Jean Nunes dos Santos ◽  
...  
Keyword(s):  
Wound Healing ◽  
Early Stage ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Laser Phototherapy ◽  
Hyperlipidic Diet

Effects of genistein on early-stage cutaneous wound healing

2011 ◽  
Vol 410 (3) ◽  
pp. 514-519 ◽  
Author(s):  
Eunkyo Park ◽  
Seung Min Lee ◽  
In-Kyung Jung ◽  
Yunsook Lim ◽  
Jung-Hyun Kim
Keyword(s):  
Wound Healing ◽  
Early Stage ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound
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