scholarly journals Replicative and radiation-induced aging: a comparison of gene expression profiles

Aging ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 2378-2387 ◽  
Author(s):  
Alexander M. Aliper ◽  
Marine E. Bozdaganyan ◽  
Philipp S. Orekhov ◽  
Alex Zhavoronkov ◽  
Andreyan N. Osipov
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Radiation Induced

scholarly journals Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease

2017 ◽  
Vol 10 (4) ◽  
pp. 425-437 ◽  
Author(s):  
Isabel L. Jackson ◽  
Fitsum Baye ◽  
Chirayu P. Goswami ◽  
Barry P. Katz ◽  
Andrew Zodda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Disease ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Radiation Induced

Gene Expression Profiles for Radiation-induced Thyroid Cancer

2011 ◽  
Vol 23 (4) ◽  
pp. 282-288 ◽  
Author(s):  
C. Maenhaut ◽  
V. Detours ◽  
G. Dom ◽  
D. Handkiewicz-Junak ◽  
M. Oczko-Wojciechowska ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Radiation Induced

scholarly journals Gene Expression Profiles Reveal Extracellular Matrix and Inflammatory Signaling in Radiation-Induced Premature Differentiation of Human Fibroblast in vitro

2021 ◽  
Vol 9 ◽  
Author(s):  
Carsten Herskind ◽  
Carsten Sticht ◽  
Ahmad Sami ◽  
Frank A. Giordano ◽  
Frederik Wenz
Keyword(s):  
Gene Expression ◽  
Extracellular Matrix ◽  
Human Skin ◽  
Pathway Analysis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Inflammatory Reactions ◽  
Signaling Mechanisms ◽  
Radiation Induced

PurposeFibroblasts are considered to play a major role in the development of fibrotic reaction after radiotherapy and premature radiation-induced differentiation has been proposed as a cellular basis. The purpose was to relate gene expression profiles to radiation-induced phenotypic changes of human skin fibroblasts relevant for radiogenic fibrosis.Materials and MethodsExponentially growing or confluent human skin fibroblast strains were irradiated in vitro with 1–3 fractions of 4 Gy X-rays. The differentiated phenotype was detected by cytomorphological scoring and immunofluorescence microscopy. Microarray analysis was performed on Human Genome U133 plus2.0 microarrays (Affymetrix) with JMP Genomics software, and pathway analysis with Reactome R-package. The expression levels and kinetics of selected genes were validated with quantitative real-time PCR (qPCR) and Western blotting.ResultsIrradiation of exponentially growing fibroblast with 1 × 4 Gy resulted in phenotypic differentiation over a 5-day period. This was accompanied by downregulation of cell cycle-related genes and upregulation of collagen and other extracellular matrix (ECM)-related genes. Pathway analysis confirmed inactivation of proliferation and upregulation of ECM- and glycosaminoglycan (GAG)-related pathways. Furthermore, pathways related to inflammatory reactions were upregulated, and potential induction and signaling mechanisms were identified. Fractionated irradiation (3 × 4 Gy) of confluent cultures according to a previously published protocol for predicting the risk of fibrosis after radiotherapy showed similar downregulation but differences in upregulated genes and pathways.ConclusionGene expression profiles after irradiation of exponentially growing cells were related to radiation-induced differentiation and inflammatory reactions, and potential signaling mechanisms. Upregulated pathways by different irradiation protocols may reflect different aspects of the fibrogenic process thus providing a model system for further hypothesis-based studies of radiation-induced fibrogenesis.

Regulators and mediators of radiation-induced fibrosis: Gene expression profiles and a rationale for Smad3 inhibition

2010 ◽  
Vol 143 (4) ◽  
pp. 525-530 ◽  
Author(s):  
Judy W. Lee ◽  
Richard A. Zoumalan ◽  
Cristian D. Valenzuela ◽  
Phuong D. Nguyen ◽  
John P. Tutela ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Radiation Induced

Radiation-Induced Changes in Gene-Expression Profiles for the SCC VII Tumor Cells Grown In Vitro and In Vivo

2006 ◽  
Vol 8 (7-8) ◽  
pp. 1263-1272 ◽  
Author(s):  
John A. Cook ◽  
Eric Y. Chuang ◽  
Mong-Hsun Tsai ◽  
Debbie Coffin ◽  
William Degraff ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Radiation Induced ◽  
Induced Changes

1327: Gene Expression Profiles in Benign Prostatic Hyperplasia

2004 ◽  
Vol 171 (4S) ◽  
pp. 349-350
Author(s):  
Gaelle Fromont ◽  
Michel Vidaud ◽  
Alain Latil ◽  
Guy Vallancien ◽  
Pierre Validire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Benign Prostatic Hyperplasia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Prostatic Hyperplasia
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