scholarly journals Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma – a retrospective study using TCGA database

Aging ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1633-1647 ◽  
Author(s):  
Jingcheng Zhou ◽  
Jiangyi Wang ◽  
Baoan Hong ◽  
Kaifang Ma ◽  
Haibiao Xie ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Gene Signatures

DYSF expression in clear cell renal cell carcinoma: A retrospective study of 2 independent cohorts

2019 ◽  
Vol 37 (10) ◽  
pp. 735-741 ◽  
Author(s):  
Mihyang Ha ◽  
Hoim Jeong ◽  
Jong Seong Roh ◽  
Beomgu Lee ◽  
Myoung-Eun Han ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

Sunitinib in advanced metastatic non-clear cell renal cell carcinoma: a single institution retrospective study

2012 ◽  
Vol 8 (12) ◽  
pp. 1605-1612 ◽  
Author(s):  
Chiara Paglino ◽  
Ilaria Imarisio ◽  
Carlo Ganini ◽  
Patrizia Morbini ◽  
Alessandro Vercelli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Single Institution ◽  
Cell Renal Cell Carcinoma

scholarly journals Eosinophilic features in clear cell renal cell carcinoma correlate with outcomes of immune checkpoint and angiogenesis blockade

2021 ◽  
Vol 9 (9) ◽  
pp. e002922
Author(s):  
Takashi Yoshida ◽  
Chisato Ohe ◽  
Junichi Ikeda ◽  
Naho Atsumi ◽  
Haruyuki Ohsugi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Immune Checkpoint ◽  
Clinical Benefit ◽  
Renal Cell ◽  
Clear Cell ◽  
Therapy Group ◽  
Cell Renal Cell Carcinoma ◽  
Gene Signatures ◽  
Type Gene

BackgroundClear cell renal cell carcinoma (ccRCC) displays heterogeneity in appearance—a distinctive pale clear to eosinophilic cytoplasm; however, little is known about the underlying mechanisms and clinical implications. We investigated the role of these eosinophilic features in ccRCC on oncological outcomes and response to tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs).MethodsOne-hundred and thirty-eight ccRCC cases undergoing radical surgery (cohort 1) and 54 metastatic ccRCC cases receiving either TKIs or ICIs (cohort 2) were included. After histological evaluation, all cases were divided into three phenotypes based on the eosinophilic features at the highest-grade area: clear, mixed, or eosinophilic type. Gene expression and immunohistochemical analyses were performed to explore the potential mechanisms of these phenotypes in cohort 1. Further, the association of the three phenotypes with the best objective response to TKI or ICI, clinical benefit (complete/partial response or stable disease), and overall survival (OS) was assessed in cohort 2.ResultsThe clear type was significantly associated with increased hypoxia as well as angiogenesis gene signatures compared with the eosinophilic type. Gene signatures and protein expression related to effector T cell and immune checkpoint molecules were elevated to a greater extent in the eosinophilic type, followed by the mixed and clear types. The mixed and eosinophilic types exhibited greater PBRM1-negativity and increased prevalence of the epithelial-mesenchymal transition gene signature than the clear type. In the mixed/eosinophilic types of cohort 2, significant clinical benefit was observed in the ICI therapy group versus the TKI therapy group (p=0.035), and TKI therapy vs ICI therapy was an independent factor for worse prognosis of OS (HR 3.236; p=0.012).ConclusionThe histological phenotype based on the eosinophilic features, which are linked to major immunological mechanisms of ccRCC, was significantly correlated with therapeutic efficacy.

scholarly journals Comprehensive assessment gene signatures for clear cell renal cell carcinoma prognosis

Medicine ◽  
2018 ◽  
Vol 97 (44) ◽  
pp. e12679 ◽  
Author(s):  
Peng Chang ◽  
Zhitong Bing ◽  
Jinhui Tian ◽  
Jingyun Zhang ◽  
Xiuxia Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Comprehensive Assessment ◽  
Cell Renal Cell Carcinoma ◽  
Gene Signatures
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