scholarly journals Integrin α7 is overexpressed and correlates with higher pathological grade, increased T stage, advanced TNM stage as well as worse survival in clear cell renal cell carcinoma patients: A retrospective study

2019 ◽  
Vol 34 (1) ◽  
Author(s):  
Yue Chen ◽  
Yang Wang ◽  
Zhixing Cai ◽  
Xiaoli Fan ◽  
Yi Zhang
Keyword(s):  
Renal Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Tnm Stage ◽  
Pathological Grade ◽  
Cell Renal Cell Carcinoma ◽  
T Stage

DYSF expression in clear cell renal cell carcinoma: A retrospective study of 2 independent cohorts

2019 ◽  
Vol 37 (10) ◽  
pp. 735-741 ◽  
Author(s):  
Mihyang Ha ◽  
Hoim Jeong ◽  
Jong Seong Roh ◽  
Beomgu Lee ◽  
Myoung-Eun Han ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

Use of preoperative C-reactive protein to improve predictive accuracy in clear cell renal cell carcinoma.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 474-474
Author(s):  
Stephan Kruck ◽  
Felix K. Chun ◽  
Axel S. Merseburger ◽  
Hossein Tezval ◽  
Marcus Scharpf ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Predictive Accuracy ◽  
Tnm Stage ◽  
C Reactive Protein ◽  
Cell Renal Cell Carcinoma ◽  
Reactive Protein ◽  
Karnofsky Index

474 Background: White blood cell count (WBC) and C-reactive protein (CRP) are reliable biomarkers in clear cell renal cell carcinoma (ccRCC). Nevertheless, accepted cut-offs values for risk stratifications are missing. This study re-evaluated the prognostic and predictive significance of preoperatively WBC and CRP that independently predicts patient prognosis and to determine optimal cut-off values for CRP. Methods: 327 patients with surgery for ccRCC were retrospectively evaluated from 1996 to 2005. Cox-proportional hazard models were used, adjusted for the effects of tumor stage, tumor size, Fuhrman grade, and Karnofsky-Index; and to evaluate the prognostic significance of WBC and CRP; and to identify cut-off values. Identified cut-offs were correlated with clinico-pathological parameters and used to estimate cancer-specific survival (CSS). To prove any additional predictive accuracy of the identified cut-off it was compared to a clinico-pathological base model using Harrell c-index. Results: In univariable analyses WBC was a significant prognostic marker at a concentration of 9.5/µl (HR: 1.83) and 11.0/µl (HR: 2.09) and supported a CRP value of 0.25 mg/dL (HR: 6.47, p < 0.001) and 0.5mg/dL (HR: 7.15, p < 0.001) as potential cut-off values. If adjusted by the multivariable models WBC showed no clear breakpoint, but a CRP-value of 0.25mg/dL (HR: 2.80, p = 0.027) proved to be optimal. Reduced CSS was proven for CRP 0.25 mg/dL (median: 69.9 vs. 92.3 months). Median follow-up was 57.5 months with 72 (22%) tumor related deaths. The final model built by the addition of CRP 0.25mg/dL did not improve predictive accuracy (c-index = 0.877) than compared to the clinico-pathological base model (c-index =0.881) which included TNM-stage, grading and Karnofsky-Index. Conclusions: Multivariable analyses revealed an optimal breakpoint of CRP at a value of 0.25mg/dL best to stratify patients at risk of cancer-specific mortality, but CRP 0.25mg/dL added no additional information in the prediction model. Therefore we cannot recommend to measure CRP as the traditional parameters of TNM-stage, grading and Karnofsky-Index were already of high predictive accuracy.

Sunitinib in advanced metastatic non-clear cell renal cell carcinoma: a single institution retrospective study

2012 ◽  
Vol 8 (12) ◽  
pp. 1605-1612 ◽  
Author(s):  
Chiara Paglino ◽  
Ilaria Imarisio ◽  
Carlo Ganini ◽  
Patrizia Morbini ◽  
Alessandro Vercelli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Single Institution ◽  
Cell Renal Cell Carcinoma

scholarly journals Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma – a retrospective study using TCGA database

Aging ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1633-1647 ◽  
Author(s):  
Jingcheng Zhou ◽  
Jiangyi Wang ◽  
Baoan Hong ◽  
Kaifang Ma ◽  
Haibiao Xie ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Gene Signatures
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