scholarly journals BMP2 promotes proliferation and invasion of nasopharyngeal carcinoma cells via mTORC1 pathway

Aging ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 1326-1340 ◽  
Author(s):  
Meng-He Wang ◽  
Xiao-Min Zhou ◽  
Mei-Yin Zhang ◽  
Lu Shi ◽  
Ruo-Wen Xiao ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Carcinoma Cells ◽  
Mtorc1 Pathway ◽  
Proliferation And Invasion

Silencing of c-Met by RNA interference inhibits the survival, proliferation, and invasion of nasopharyngeal carcinoma cells

Tumor Biology ◽  
2011 ◽  
Vol 32 (6) ◽  
pp. 1217-1224 ◽  
Author(s):  
Yuncheng Li ◽  
Sulin Zhang ◽  
Zhengang Tang ◽  
Jian Chen ◽  
Weijia Kong
Keyword(s):  
Rna Interference ◽  
Nasopharyngeal Carcinoma ◽  
Carcinoma Cells ◽  
Proliferation And Invasion

scholarly journals Heparanase is involved in the proliferation and invasion of nasopharyngeal carcinoma cells

2013 ◽  
Vol 29 (5) ◽  
pp. 1888-1894 ◽  
Author(s):  
JINZHANG CHEN ◽  
DAYONG ZHENG ◽  
JIE SHEN ◽  
JIAN RUAN ◽  
AIMIN LI ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Carcinoma Cells ◽  
Proliferation And Invasion

Experimental Study on the Effect of miR-200b Regulation of Bone Morphogenetic Protein (BMP)-2 Expression on the Proliferation and Invasion of Nasopharyngeal Carcinoma Cells

2021 ◽  
Vol 11 (7) ◽  
pp. 1365-1371
Author(s):  
Yi Xiao ◽  
Peiei Li ◽  
Xiaoming Lu
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cancer Cells ◽  
Cell Invasion ◽  
Nasopharyngeal Cancer ◽  
Carcinoma Cells ◽  
Proliferative Capacity ◽  
Morphogenetic Protein ◽  
Invasive Capacity ◽  
And Migration ◽  
Proliferation And Invasion

BMP is an important member of the skeletal junction proteins associated with cell invasion, metastasis, and migration. MiR-200b is associated with the progression of several tumors. This study investigated whether miR-200b plays a role in regulating BMP-2 expression and affecting the proliferation and invasion of nasopharyngeal carcinoma cells. The nasopharyngeal carcinoma tissues with different TNM stages were collected and the proliferative nasal tissues alone were used as controls to detect the expression of miR-200b and BMP by RT-PCR. The nasopharyngeal carcinoma cell line CNE1 cells were divided into miR-NC group, miR-200b mimic group, siRNA-NC group, and siRNA-BMP-2 group, to detect BMP-2 level, cell invasion and proliferation ability by transwell. The BMP-2 mRNA expressed in nasopharyngeal carcinoma tissues was significantly elevated compared to controls and correlated with TNM stage. BMP-2 was higher in tumor tissues than in controls, however, the expression profile of miR-200b was opposite to BMP-2. Transfection with miR-200b mimic or siRNA-BMP-2 significantly down-regulated BMP-2 in CNE1 cells and attenuated cell invasive and proliferative capacity. Reduced expression of miR-200b is associated with elevated BMP-2 expression and increased invasive capacity of nasopharyngeal cancer cells. Overexpression of miR-200b reduces the invasive and proliferative capacity of nasopharyngeal cancer cells by targeting and inhibiting BMP-2 expression.

scholarly journals Andrographolide Suppresses Proliferation of Nasopharyngeal Carcinoma Cells via Attenuating NF-κB Pathway

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Tao Peng ◽  
Min Hu ◽  
Ting-Ting Wu ◽  
Cen Zhang ◽  
Zhe Chen ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Anticancer Activity ◽  
Target Genes ◽  
Therapeutic Potential ◽  
Carcinoma Cells ◽  
Anticancer Activities ◽  
Potential Therapeutic Target ◽  
Cycle Arrest ◽  
Anticancer Effects ◽  
Proliferation And Invasion

Andrographolide (Andro) has been reported to have anticancer activity in multiple types of cancer due to its capacity to inactivate NF-κB pathway. Previous studies showed the therapeutic potential of targeting NF-κB pathway in nasopharyngeal carcinoma (NPC). However, the anticancer activity of Andro in NPC has not been reported. In this study, we defined the anticancer effects of Andro in NPC and elucidated its potential mechanisms of action. Our results showed that Andro significantly inhibited the proliferation and invasion of NPC cells (P<0.05, resp.). These anticancer activities were associated with cell apoptosis, cell death and induction of cell cycle arrest, and the downregulation of NF-κB target genes. This work provides evidence that NF-κB pathway is a potential therapeutic target and may also be indispensable in the Andro-mediated anticancer activities in nasopharyngeal carcinoma.

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