scholarly journals miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway by targeting Capn4

2017 ◽  
Vol Volume 10 ◽  
pp. 2711-2720 ◽  
Author(s):  
Haili Hu ◽  
Guanghui Wang ◽  
Congying Li
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Signaling Pathway ◽  
Carcinoma Cells ◽  
Beta Catenin ◽  
Proliferation And Invasion

Silencing of c-Met by RNA interference inhibits the survival, proliferation, and invasion of nasopharyngeal carcinoma cells

Tumor Biology ◽  
2011 ◽  
Vol 32 (6) ◽  
pp. 1217-1224 ◽  
Author(s):  
Yuncheng Li ◽  
Sulin Zhang ◽  
Zhengang Tang ◽  
Jian Chen ◽  
Weijia Kong
Keyword(s):  
Rna Interference ◽  
Nasopharyngeal Carcinoma ◽  
Carcinoma Cells ◽  
Proliferation And Invasion

scholarly journals The Effects of miR-195-5p/MMP14 on Proliferation and Invasion of Cervical Carcinoma Cells Through TNF Signaling Pathway Based on Bioinformatics Analysis of Microarray Profiling

2018 ◽  
Vol 50 (4) ◽  
pp. 1398-1413 ◽  
Author(s):  
Min Li ◽  
Chun-Xia Ren ◽  
Jian-Mei Zhang ◽  
Xiao-Yan Xin ◽  
Teng Hua ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Signaling Pathway ◽  
Microarray Analysis ◽  
Cervical Carcinoma ◽  
Carcinoma Cells ◽  
Gene Set Enrichment Analysis ◽  
Qrt Pcr ◽  
In Vivo Experiment ◽  
Proliferation And Invasion

Background/Aims: This study is aimed at identification of miR-195-5p/MMP14 expression in cervical cancer (CC) and their roles on cell proliferation and invasion profile of CC cells through TNF signaling pathway in CC. Methods: Microarray analysis, gene set enrichment analysis (GSEA) and DAVID were used to analyze differentially expressed miRNAs, mRNAs and signaling pathways. MiR-195-5p and MMP14 expression levels in CC cell were determined by qRT-PCR. Western blot was employed to measure MMP14 and TNF signaling pathway-relating protein level. Luciferase reporter system was used to confirm the targeting relationship between MMP14 and miR-195-5p. Cell proliferation and invasion was respectively deeded by CCK8, transwell. In vivo experiment was carried out to study the impact of MMP14 and miR-195-5p on CC development in mice. Results: The microarray analysis and the results of qRT-PCR determined that miR-195-5p was under-expressed and MMP14 was over-expressed in CC cells. GSEA and DAVID analysis showed that TNF signaling pathway was regulated by miR-195-5p/MMP14 and activated in cervical carcinoma cells. The miR-195-5p and MMP14 have a negative regulation relation. In vivo experiment found that down-regulated MMP14 and up-regulated miR-195-5p suppressed the tumor development. Conclusion: Our results suggest that MMP14 is a direct target of miR-195-5p, and down-regulated MMP14 and up-regulated miR-195-5p suppressed proliferation and invasion of CC cells by inhibiting TNF signaling pathway.

scholarly journals Heparanase is involved in the proliferation and invasion of nasopharyngeal carcinoma cells

2013 ◽  
Vol 29 (5) ◽  
pp. 1888-1894 ◽  
Author(s):  
JINZHANG CHEN ◽  
DAYONG ZHENG ◽  
JIE SHEN ◽  
JIAN RUAN ◽  
AIMIN LI ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Carcinoma Cells ◽  
Proliferation And Invasion

The Enhancement of Radiation Sensitivity in Nasopharyngeal Carcinoma Cells via Activation of the Rac1/NADPH Signaling Pathway

2016 ◽  
Vol 185 (6) ◽  
pp. 638-646 ◽  
Author(s):  
Chunmiao Wang ◽  
Zhiyu Pan ◽  
Huaxin Hou ◽  
Danrong Li ◽  
Yuanyuan Mo ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Signaling Pathway ◽  
Radiation Sensitivity ◽  
Carcinoma Cells
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