scholarly journals Quiescin-sulfhydryl oxidase inhibits prion formation in vitro

Aging ◽  
2016 ◽  
Vol 8 (12) ◽  
pp. 3419-3429 ◽  
Author(s):  
Yi-An Zhan ◽  
Romany Abskharon ◽  
Yu Li ◽  
Jue Yuan ◽  
Liang Zeng ◽  
...  
Keyword(s):  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Secretory mouse quiescin sulfhydryl oxidase 1 aggregates defected human and mouse spermatozoa in vitro and in vivo

iScience ◽  
2021 ◽  
Vol 24 (10) ◽  
pp. 103167
Author(s):  
Tse-En Wang ◽  
Ling-Yu Yeh ◽  
Robert Kuo-Kuang Lee ◽  
Chung-Hao Lu ◽  
Tsung-Hsien Yang ◽  
...  
Keyword(s):  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase ◽  
Human And Mouse

scholarly journals Quiescin Sulfhydryl Oxidase 2 Overexpression Predicts Poor Prognosis and Tumor Progression in Patients With Colorectal Cancer: A Study Based on Data Mining and Clinical Verification

2021 ◽  
Vol 9 ◽  
Author(s):  
Tao Jiang ◽  
Li Zheng ◽  
Xia Li ◽  
Jia Liu ◽  
Hu Song ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Regression Model ◽  
Signaling Pathways ◽  
Cox Regression ◽  
Gene Set Enrichment Analysis ◽  
Clinicopathological Parameters ◽  
Sulfhydryl Oxidase ◽  
Cox Regression Model ◽  
Quiescin Sulfhydryl Oxidase

Background: As a member of the atypical thiol oxidase family, quiescin sulfhydryl oxidase 2 (QSOX2) has been reported to play an important role in several biological processes, but the expression and function of QSOX2 in colorectal cancer (CRC) remains elusive.Methods: The difference of QSOX2 expression, and its relationship with clinicopathological features and prognosis in CRC, was analyzed by bioinformatic analysis and validated by clinical CRC specimen cohort. The functional characterization of QSOX2 was detected via in vitro and vivo experiments in CRC cell lines, while the potential signaling pathways were predicted by Gene Set Enrichment Analysis (GSEA).Results: Our data based on bioinformatical analysis and clinical validation demonstrated that the expression of QSOX2 in CRC tissues was significantly upregulated. Additionally, the chi-square test, logistic regression analysis, and Fisher’s exact test showed that QSOX2 overexpression was significantly correlated with advanced clinicopathological parameters, such as pathological stage and lymph node metastasis. The Kaplan–Meier curves and univariate Cox regression model showed that QSOX2 overexpression predicts poor overall survival (OS) and disease-free survival (DFS) in CRC patients. More importantly, multivariate Cox regression model showed that QSOX2 overexpression could serve as an independent factor for CRC patients. In vitro and vivo data showed that the proliferation and metastasis ability of CRC cells were suppressed on condition of QSOX2 inhibition. In addition, GSEA showed that the QSOX2 high expression phenotype has enriched multiple potential cancer-related signaling pathways.Conclusion: QSOX2 overexpression is strongly associated with malignant progression and poor oncological outcomes in CRC. QSOX2 might act as a novel biomarker for prognosis prediction and a new target for biotherapy in CRC.

scholarly journals Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis

2018 ◽  
Vol 19 (10) ◽  
pp. 3213 ◽  
Author(s):  
Hye-Jin Sung ◽  
Jung-Mo Ahn ◽  
Yeon-Hee Yoon ◽  
Sang-Su Na ◽  
Young-Jin Choi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Lung Cancer Cells ◽  
Migration And Invasion ◽  
Sulfhydryl Oxidase ◽  
Lung Cancers ◽  
Normal Tissues ◽  
Cancer Tissues ◽  
Quiescin Sulfhydryl Oxidase

As lung cancer shows the highest mortality in cancer-related death, serum biomarkers are demanded for lung cancer diagnosis and its treatment. To discover lung cancer protein biomarkers, secreted proteins from primary cultured lung cancer and adjacent normal tissues from patients were subjected to LC/MS–MS proteomic analysis. Quiescin sulfhydryl oxidase (QSOX1) was selected as a biomarker candidate from the enriched proteins in the secretion of lung cancer cells. QSOX1 levels were higher in 82% (51 of 62 tissues) of lung cancer tissues compared to adjacent normal tissues. Importantly, QSOX1 serum levels were significantly higher in cancer patients (p < 0.05, Area Under curve (AUC) = 0.89) when measured by multiple reaction monitoring (MRM). Higher levels of QSOX1 were also uniquely detected in lung cancer tissues, among several other solid cancers, by immunohistochemistry. QSOX1-knock-downed Lewis lung cancer (LLC) cells were less viable from oxidative stress and reduced migration and invasion. In addition, LLC mouse models with QSOX1 knock-down also proved that QSOX1 functions in promoting cancer metastasis. In conclusion, QSOX1 might be a lung cancer tissue-derived biomarker and be involved in the promotion of lung cancers, and thus can be a therapeutic target for lung cancers.

scholarly journals The Quiescin Sulfhydryl Oxidase (hQSOX1b) Tunes the Expression of Resistin-Like Molecule Alpha (RELM-α or mFIZZ1) in a Wheat Germ Cell-Free Extract

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e55621 ◽  
Author(s):  
Wael Gad ◽  
Meera G. Nair ◽  
Karolien Van Belle ◽  
Khadija Wahni ◽  
Henri De Greve ◽  
...  
Keyword(s):  
Germ Cell ◽  
Wheat Germ ◽  
Cell Free Extract ◽  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Characterization of recombinant rice quiescin sulfhydryl oxidase and its improvement effect on wheat flour-processing quality

2020 ◽  
Vol 333 ◽  
pp. 127492
Author(s):  
Nian Du ◽  
Zhen-Cheng Wei ◽  
Yuan-Yuan Deng ◽  
Yan Zhang ◽  
Xiao-Jun Tang ◽  
...  
Keyword(s):  
Wheat Flour ◽  
Processing Quality ◽  
Sulfhydryl Oxidase ◽  
Improvement Effect ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase

FEBS Letters ◽  
2012 ◽  
Vol 586 (23) ◽  
pp. 4119-4125 ◽  
Author(s):  
Keren Limor-Waisberg ◽  
Assaf Alon ◽  
Tevie Mehlman ◽  
Deborah Fass
Keyword(s):  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Protein Substrate Discrimination in the Quiescin Sulfhydryl Oxidase (QSOX) Family

Biochemistry ◽  
2012 ◽  
Vol 51 (20) ◽  
pp. 4226-4235 ◽  
Author(s):  
Jennifer A. Codding ◽  
Benjamin A. Israel ◽  
Colin Thorpe
Keyword(s):  
Sulfhydryl Oxidase ◽  
Protein Substrate ◽  
Quiescin Sulfhydryl Oxidase ◽  
Substrate Discrimination

scholarly journals Diversification of Quiescin sulfhydryl oxidase in a preserved framework for redox relay

2013 ◽  
Vol 13 (1) ◽  
pp. 70 ◽  
Author(s):  
Keren Limor-Waisberg ◽  
Shifra Ben-Dor ◽  
Deborah Fass
Keyword(s):  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase
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