scholarly journals Protein Substrate Discrimination in the Quiescin Sulfhydryl Oxidase (QSOX) Family

Biochemistry ◽  
2012 ◽  
Vol 51 (20) ◽  
pp. 4226-4235 ◽  
Author(s):  
Jennifer A. Codding ◽  
Benjamin A. Israel ◽  
Colin Thorpe
Keyword(s):  
Sulfhydryl Oxidase ◽  
Protein Substrate ◽  
Quiescin Sulfhydryl Oxidase ◽  
Substrate Discrimination

scholarly journals Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis

2018 ◽  
Vol 19 (10) ◽  
pp. 3213 ◽  
Author(s):  
Hye-Jin Sung ◽  
Jung-Mo Ahn ◽  
Yeon-Hee Yoon ◽  
Sang-Su Na ◽  
Young-Jin Choi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Lung Cancer Cells ◽  
Migration And Invasion ◽  
Sulfhydryl Oxidase ◽  
Lung Cancers ◽  
Normal Tissues ◽  
Cancer Tissues ◽  
Quiescin Sulfhydryl Oxidase

As lung cancer shows the highest mortality in cancer-related death, serum biomarkers are demanded for lung cancer diagnosis and its treatment. To discover lung cancer protein biomarkers, secreted proteins from primary cultured lung cancer and adjacent normal tissues from patients were subjected to LC/MS–MS proteomic analysis. Quiescin sulfhydryl oxidase (QSOX1) was selected as a biomarker candidate from the enriched proteins in the secretion of lung cancer cells. QSOX1 levels were higher in 82% (51 of 62 tissues) of lung cancer tissues compared to adjacent normal tissues. Importantly, QSOX1 serum levels were significantly higher in cancer patients (p < 0.05, Area Under curve (AUC) = 0.89) when measured by multiple reaction monitoring (MRM). Higher levels of QSOX1 were also uniquely detected in lung cancer tissues, among several other solid cancers, by immunohistochemistry. QSOX1-knock-downed Lewis lung cancer (LLC) cells were less viable from oxidative stress and reduced migration and invasion. In addition, LLC mouse models with QSOX1 knock-down also proved that QSOX1 functions in promoting cancer metastasis. In conclusion, QSOX1 might be a lung cancer tissue-derived biomarker and be involved in the promotion of lung cancers, and thus can be a therapeutic target for lung cancers.

scholarly journals The Quiescin Sulfhydryl Oxidase (hQSOX1b) Tunes the Expression of Resistin-Like Molecule Alpha (RELM-α or mFIZZ1) in a Wheat Germ Cell-Free Extract

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e55621 ◽  
Author(s):  
Wael Gad ◽  
Meera G. Nair ◽  
Karolien Van Belle ◽  
Khadija Wahni ◽  
Henri De Greve ◽  
...  
Keyword(s):  
Germ Cell ◽  
Wheat Germ ◽  
Cell Free Extract ◽  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Characterization of recombinant rice quiescin sulfhydryl oxidase and its improvement effect on wheat flour-processing quality

2020 ◽  
Vol 333 ◽  
pp. 127492
Author(s):  
Nian Du ◽  
Zhen-Cheng Wei ◽  
Yuan-Yuan Deng ◽  
Yan Zhang ◽  
Xiao-Jun Tang ◽  
...  
Keyword(s):  
Wheat Flour ◽  
Processing Quality ◽  
Sulfhydryl Oxidase ◽  
Improvement Effect ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase

FEBS Letters ◽  
2012 ◽  
Vol 586 (23) ◽  
pp. 4119-4125 ◽  
Author(s):  
Keren Limor-Waisberg ◽  
Assaf Alon ◽  
Tevie Mehlman ◽  
Deborah Fass
Keyword(s):  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Diversification of Quiescin sulfhydryl oxidase in a preserved framework for redox relay

2013 ◽  
Vol 13 (1) ◽  
pp. 70 ◽  
Author(s):  
Keren Limor-Waisberg ◽  
Shifra Ben-Dor ◽  
Deborah Fass
Keyword(s):  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals An Arabidopsis quiescin-sulfhydryl oxidase regulates cation homeostasis at the root symplast–xylem interface

2007 ◽  
Vol 26 (13) ◽  
pp. 3203-3215 ◽  
Author(s):  
Santiago Alejandro ◽  
Pedro L Rodríguez ◽  
Jose M Bellés ◽  
Lynne Yenush ◽  
María J García-Sanchez ◽  
...  
Keyword(s):  
Sulfhydryl Oxidase ◽  
Cation Homeostasis ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Quiescin-sulfhydryl oxidase inhibits prion formation in vitro

Aging ◽  
2016 ◽  
Vol 8 (12) ◽  
pp. 3419-3429 ◽  
Author(s):  
Yi-An Zhan ◽  
Romany Abskharon ◽  
Yu Li ◽  
Jue Yuan ◽  
Liang Zeng ◽  
...  
Keyword(s):  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase

scholarly journals Disulfide bond formation activity of soybean quiescin sulfhydryl oxidase

FEBS Journal ◽  
2014 ◽  
Vol 281 (23) ◽  
pp. 5341-5355 ◽  
Author(s):  
Aya Okuda ◽  
Motonori Matsusaki ◽  
Yuki Higashino ◽  
Taro Masuda ◽  
Reiko Urade
Keyword(s):  
Disulfide Bond ◽  
Bond Formation ◽  
Disulfide Bond Formation ◽  
Sulfhydryl Oxidase ◽  
Quiescin Sulfhydryl Oxidase
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