scholarly journals Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function

Aging ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 2871-2896 ◽  
Author(s):  
Juhyun Oh ◽  
Indranil Sinha ◽  
Kah Yong Tan ◽  
Bernard Rosner ◽  
Jonathan M. Dreyfuss ◽  
...  
Keyword(s):  
Stem Cell ◽  
Satellite Cell ◽  
Cell Function ◽  
Muscle Stem Cell ◽  
Satellite Cell Niche ◽  
Cell Niche

scholarly journals Stem Cell Function, Self-Renewal, and Behavioral Heterogeneity of Cells from the Adult Muscle Satellite Cell Niche

Cell ◽  
2005 ◽  
Vol 122 (2) ◽  
pp. 289-301 ◽  
Author(s):  
Charlotte A. Collins ◽  
Irwin Olsen ◽  
Peter S. Zammit ◽  
Louise Heslop ◽  
Aviva Petrie ◽  
...  
Keyword(s):  
Stem Cell ◽  
Satellite Cell ◽  
Cell Function ◽  
Muscle Satellite Cell ◽  
Self Renewal ◽  
Adult Muscle ◽  
Satellite Cell Niche ◽  
Behavioral Heterogeneity ◽  
Cell Niche

scholarly journals Molecular Regulation and Rejuvenation of Muscle Stem (Satellite) Cell Aging

2015 ◽  
Vol 7 (2) ◽  
pp. 73
Author(s):  
Anna Meiliana ◽  
Nurrani Mustika Dewi ◽  
Andi Wijaya
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Satellite Cell ◽  
Muscle Mass ◽  
Satellite Cells ◽  
Cell Function ◽  
Muscle Stem Cell ◽  
Muscle Aging ◽  
Age Related

BACKGROUND: Age-related muscle loss leads to lack of muscle strength, resulting in reduced posture and mobility and an increased risk of falls, all of which contribute to a decrease in quality of life. Skeletal muscle regeneration is a complex process, which is not yet completely understood.CONTENT: Skeletal muscle undergoes a progressive age-related loss in mass and function. Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite cell function may contribute to the age-associated decrease in muscle mass. Recent studies have delineated that the aging process in organ stem cells is largely caused by age-specific changes in the differentiated niches, and that regenerative outcomes often depend on the age of the niche, rather than on stem cell age. It is likely that epigenetic states will be better define such key satellite cell features as prolonged quiescence and lineage fidelity. It is also likely that DNA and histone modifications will underlie many of the changes in aged satellite cells that account for age-related declines in functionality and rejuvenation through exposure to the systemic environment.SUMMARY: Skeletal muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and regenerative capacity, which can lead to sarcopenia and increased mortality. Although the mechanisms underlying sarcopenia remain unclear, the skeletal muscle stem cell, or satellite cell, is required for muscle regeneration. Decreased muscle stem cell function in aging has long been shown to depend on altered environmental cues, whereas the contribution of intrinsic mechanisms remained less clear. Signals in the aged niche were shown to cause permanent defects in the ability of satellite cells to return to quiescence, ultimately also impairing the maintenance of self-renewing satellite cells. Therefore, only anti-aging strategies taking both factors, the stem cell niche and the stem cells per se, into consideration may ultimately be successful.KEYWORDS: satellite cell, muscle, aging, niche, regenerations

scholarly journals Macrophages provide a transient muscle stem cell niche via NAMPT secretion

2020 ◽  
Author(s):  
Dhanushika Ratnayake ◽  
Phong D. Nguyen ◽  
Fernando J. Rossello ◽  
Verena C. Wimmer ◽  
Abdulsalam I. Isiaku ◽  
...  
Keyword(s):  
Stem Cell ◽  
Satellite Cell ◽  
Stem Cell Niche ◽  
Wound Repair ◽  
Repair Process ◽  
Cellular Interactions ◽  
Muscle Stem Cell ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Specific Subset ◽  
Cell Niche

AbstractSkeletal muscle is paradigmatic of a regenerative tissue that repairs itself via the activation of a resident stem cell1. Termed the satellite cell, these normally quiescent cells are induced to proliferate by ill-defined wound-derived signals2. Identifying the source and nature of these pro-regenerative cues has been hampered by an inability to visualise the complex cellular interactions that occur within the wound environment. We therefore developed a zebrafish muscle injury model to systematically capture satellite cell interactions within the injury site, in real time, throughout the repair process. This analysis identified that a specific subset of macrophages ‘dwells’ within the injury, establishing a transient but obligate stem cell niche required for stem cell proliferation. Single cell profiling identified specific signals secreted from dwelling macrophages that include the cytokine, Nicotinamide phosphoribosyltransferase (NAMPT/Visfatin/PBEF). Here we show that NAMPT secretion from the macrophage niche is required for muscle regeneration, acting through the C-C motif chemokine receptor type 5 (CCR5) expressed on muscle stem cells. This analysis reveals that along with their well-described ability to modulate the pro-inflammatory and anti-inflammatory phases of wound repair, specific macrophage populations also provide a transient stem cell-activating niche, directly supplying pro-proliferative cues that govern the timing and rate of muscle stem cell-mediated repair processes.

scholarly journals Influence of exercise and aging on extracellular matrix composition in the skeletal muscle stem cell niche

2016 ◽  
Vol 121 (5) ◽  
pp. 1053-1058 ◽  
Author(s):  
Koyal Garg ◽  
Marni D. Boppart
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Satellite Cells ◽  
Stem Cell Niche ◽  
Cell Function ◽  
Skeletal Muscle Regeneration ◽  
Matrix Composition ◽  
Muscle Stem Cell ◽  
Cell Niche ◽  
Exercise And Aging

Skeletal muscle is endowed with a remarkable capacity for regeneration, primarily due to the reserve pool of muscle resident satellite cells. The satellite cell is the physiologically quiescent muscle stem cell that resides beneath the basal lamina and adjacent to the sarcolemma. The anatomic location of satellite cells is in close proximity to vasculature where they interact with other muscle resident stem/stromal cells (e.g., mesenchymal stem cells and pericytes) through paracrine mechanisms. This mini-review describes the components of the muscle stem cell niche, as well as the influence of exercise and aging on the muscle stem cell niche. Although exercise promotes ECM reorganization and stem cell accumulation, aging is associated with dense ECM deposition and loss of stem cell function resulting in reduced regenerative capacity and strength. An improved understanding of the niche elements will be valuable to inform the development of therapeutic interventions aimed at improving skeletal muscle regeneration and adaptation over the life span.

scholarly journals Empowering Muscle Stem Cells for the Treatment of Duchenne Muscular Dystrophy

2021 ◽  
pp. 1-14
Author(s):  
Romina L. Filippelli ◽  
Natasha C. Chang
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Cell Function ◽  
Critical Role ◽  
Membrane Integrity ◽  
Muscle Membrane ◽  
Muscle Stem Cell ◽  
Muscle Stem Cells

Duchenne muscular dystrophy (DMD) is a devastating and debilitating muscle degenerative disease affecting 1 in every 3,500 male births worldwide. DMD is progressive and fatal; accumulated weakening of the muscle tissue leads to an inability to walk and eventual loss of life due to respiratory and cardiac failure. Importantly, there remains no effective cure for DMD. DMD is caused by defective expression of the <i>DMD</i> gene, which encodes for dystrophin, a component of the dystrophin glycoprotein complex. In muscle fibers, this protein complex plays a critical role in maintaining muscle membrane integrity. Emerging studies have shown that muscle stem cells, which are adult stem cells responsible for muscle repair, are also affected in DMD. DMD muscle stem cells do not function as healthy muscle stem cells, and their impairment contributes to disease progression. Deficiencies in muscle stem cell function include impaired establishment of cell polarity leading to defective asymmetric stem cell division, reduced myogenic commitment, impaired differentiation, altered metabolism, and enhanced entry into senescence. Altogether, these findings indicate that DMD muscle stem cells are dysfunctional and have impaired regenerative potential. Although recent advances in adeno-associated vector and antisense oligonucleotide-mediated mechanisms for gene therapy have shown clinical promise, the current therapeutic strategies for muscular dystrophy do not effectively target muscle stem cells and do not address the deficiencies in muscle stem cell function. Here, we discuss the merits of restoring endogenous muscle stem cell function in degenerating muscle as a viable regenerative medicine strategy to mitigate DMD.

scholarly journals Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

Cell Reports ◽  
2019 ◽  
Vol 27 (13) ◽  
pp. 3939-3955.e6 ◽  
Author(s):  
Nora Yucel ◽  
Yu Xin Wang ◽  
Thach Mai ◽  
Ermelinda Porpiglia ◽  
Peder J. Lund ◽  
...  
Keyword(s):  
Stem Cell ◽  
Glucose Metabolism ◽  
Histone Acetylation ◽  
Cell Function ◽  
Muscle Stem Cell

scholarly journals Chronic inflammation in skeletal muscle impairs satellite cells function during regeneration: can physical exercise restore the satellite cell niche?

FEBS Journal ◽  
2018 ◽  
Vol 285 (11) ◽  
pp. 1973-1984 ◽  
Author(s):  
Luiz Augusto Perandini ◽  
Patricia Chimin ◽  
Diego da Silva Lutkemeyer ◽  
Niels Olsen Saraiva Câmara
Keyword(s):  
Skeletal Muscle ◽  
Physical Exercise ◽  
Chronic Inflammation ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Satellite Cell Niche ◽  
Cell Niche
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