scholarly journals Evidence of a metabolic reserve in the skeletal muscle of elderly people

Aging ◽  
2016 ◽  
Vol 9 (1) ◽  
pp. 52-67 ◽  
Author(s):  
Gwenael Layec ◽  
Joel D. Trinity ◽  
Corey R. Hart ◽  
Yann Le Fur ◽  
Jacob R. Sorensen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Elderly People ◽  
Metabolic Reserve

Preserved metabolic reserve capacity in skeletal muscle of post-infarction heart failure patients

2010 ◽  
Vol 22 (2) ◽  
pp. 199-206 ◽  
Author(s):  
G. Slettaløkken ◽  
T. A. Rehn ◽  
M. Munkvik ◽  
B. Rud ◽  
M. Sökjer-Petersen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Reserve Capacity ◽  
Heart Failure Patients ◽  
Metabolic Reserve ◽  
Infarction Heart

scholarly journals Prevalence of Sarcopenia and Related Factors of Skeletal Muscle Mass in Community-dwelling Frail Elderly People

2015 ◽  
Vol 30 (5) ◽  
pp. 793-796
Author(s):  
Yoshiharu NAGAI ◽  
Masami NAKAHARA ◽  
Takeyoshi SHIMODA ◽  
Yoshirou TAKANO
Keyword(s):  
Skeletal Muscle ◽  
Elderly People ◽  
Muscle Mass ◽  
Frail Elderly ◽  
Skeletal Muscle Mass ◽  
Community Dwelling ◽  
Related Factors ◽  
Frail Elderly People

Overweight in elderly people induces impaired autophagy in skeletal muscle

2017 ◽  
Vol 110 ◽  
pp. 31-41 ◽  
Author(s):  
Yaiza Potes ◽  
Beatriz de Luxán-Delgado ◽  
Susana Rodriguez-González ◽  
Marcela Rodrigues Moreira Guimarães ◽  
Juan J. Solano ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Elderly People

scholarly journals Evaluation of sarcopenia in long-lived elderly patients: comparison between the Muscle Mass Index and the Calf Circumference

2021 ◽  
Vol 100 (1) ◽  
pp. 94-95
Author(s):  
Isadora Cecília Salgado Gama ◽  
Sergio Chociay Junior ◽  
Mariana de Paula Santana ◽  
Nadine Motta Figueiredo ◽  
Nathália de Oliveira Andrade ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Skeletal Muscle ◽  
Elderly Patients ◽  
Elderly People ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
The Elderly ◽  
Calf Circumference ◽  
Extreme Longevity

The increase in life expectancy, observed in several countries, including Brazil, is due to improvements in living and health conditions and the epidemiological transition from the causes of morbidity and mortality, from infectious and parasitic diseases to chronic diseases. Furthermore, an increase in longevity, in addition to advances in science, with the improvement of diagnoses and the search for new treatments contributed to the increase in years lived1,2. However, the aging process is associated with a decrease in organic functions over the years. Sarcopenia is considered a complex geriatric syndrome and is defined as an age-related decline in skeletal muscle mass and function2. It is a major public health concern because it can result in functional decline, disability, falls, increased hospitalization costs, poor quality of life, and even deaths3. Although Dual-energy X-ray Absorptiometry (DXA) is the most used method to estimate the loss of muscle mass4 the high cost and low viability hinder its use in Primary Health Care (PHC). Methods such as Muscle Mass Index (MMI) and Calf Circumference (CC) can be used replacing DXA due to ease of access and application as well as low cost5. The Academic League of Geriatrics and Gerontology, Três Lagoas Campus, Federal Univeristy of Mato Grosso do Sul designed and executed a research intending to evaluate several aspects in elderly people with extreme longevity. One of the variables analyzed was sarcopenia, which was evaluated and compared using MMI and CC. For this purpose, a cross-sectional and quantitative study was performed in 2019/2020, with n = 69 individuals aged ≥ 90 years, of both genders, users of the Unified Health System in the town of Três Lagoas – MS. A sociodemographic questionnaire containing gender, age, and years of schooling was applied. Anthropometric data (CC and MMI) were collected in triplicate. The skeletal muscle mass was determined using the formula of Lee and collaborators which considers age, body mass, gender, ethnicity and height5. The values of MMI ​​of Janssen and collaborators were used as a reference to classify whether the nonagenarian or centenarians were sarcopenic or not6. For CC, a cutoff score ≤ 31 centimeters was adopted as a sign of sarcopenia7. The interviewed elderly had an average age of 93.5 years old, 1.3 years of schooling and 52.2% of the participants were women. The average CC was 31.2 centimeters, with 46.1% being considered sarcopenic patients according to this parameter. The average MMI was 5.1 kg/m2, with 100% of the elderly patients being considered sarcopenic through this method. There was no relationship between CC and MMI (p = 0.213). The high rates of sarcopenia found, especially using MMI and the absence of a relationship between the CC and MMI highlights the need to use more reliable methods to evaluate sarcopenia in long-lived elderly people, since the identification from CC, despite being easy and fast, may not be sensitive in this age group. These findings also lead to considering the use of more specific methods or those associated with other variables, such as Timed up and Go (TUG), for the evaluation of sarcopenia in the elderly aged 90 years or over. Future investigations should  consider the importance of validating specific instruments for elderly people in extreme longevity, as they constitute a group that has unique characteristics. The screening, monitoring, and health promotion carried out by PHC teams can promote the improvement in the quality of life of elderly people in extreme longevity.

scholarly journals Sarcopenia, Cardiopulmonary Fitness, and Physical Disability in Community-Dwelling Elderly People

2010 ◽  
Vol 90 (9) ◽  
pp. 1277-1287 ◽  
Author(s):  
Meng-Yueh Chien ◽  
Hsu-Ko Kuo ◽  
Ying-Tai Wu
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Muscle Strength ◽  
Elderly People ◽  
Muscle Mass ◽  
Physical Disability ◽  
Skeletal Muscle Mass ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Cardiopulmonary Fitness

Background Sarcopenia refers to the loss of skeletal muscle mass with aging. It is believed to be associated with functional impairment and physical disability. Objective The purposes of this study were: (1) to compare the physical activity, muscle strength (force-generating capacity), cardiopulmonary fitness, and physical disability in community-dwelling elderly people with sarcopenia, borderline sarcopenia, and normal skeletal muscle mass in Taiwan and (2) to test the hypothesis that sarcopenia is associated with physical disability and examine whether the association is mediated by decreased muscle strength or cardiopulmonary fitness. Design This was a cross-sectional investigation. Methods Two hundred seventy-five community-dwelling elderly people (148 men, 127 women) aged ≥65 years participated in the study. The participants were recruited from communities in the district of Zhongzheng, Taipei. Predicted skeletal muscle mass was estimated using a bioelectrical impedance analysis equation. The skeletal muscle mass index (SMI) was calculated by dividing skeletal muscle mass by height squared. Physical disability was assessed using the Groningen Activity Restriction Scale. Physical activity was assessed using a 7-day recall physical activity questionnaire. Cardiopulmonary fitness was assessed using a 3-minute step test, and grip strength was measured to represent muscle strength. Results Cardiopulmonary fitness was significantly lower in elderly people with sarcopenia than in those with normal SMIs. Grip strength and daily energy expenditure (kcal/kg/day) were not significantly different between the participants with sarcopenia and those with normal SMIs. The odds ratio for physical disability between the participants with sarcopenia and those with normal SMIs was 3.03 (95% confidence interval=1.21–7.61). The odds ratio decreased and the significant difference diminished after controlling for cardiopulmonary fitness. Limitations A causal relationship between sarcopenia and physical activity, cardiopulmonary fitness, and physical disability cannot be established because of the cross-sectional nature of study design. Conclusions Sarcopenia was associated with physical disability in elderly men. The association between sarcopenia and physical disability was mediated to a large extent by decreased cardiopulmonary fitness.

scholarly journals REDD1 reduces the responsiveness of mTORC1 after resistance exercise and amino acid intake in skeletal muscle of elderly people (702.4)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Marc Francaux ◽  
Bénédicte Demeulder ◽  
Damien Naslain ◽  
Raphaël Fortin ◽  
Olivier Lutz ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Resistance Exercise ◽  
Elderly People ◽  
Acid Intake ◽  
Amino Acid Intake
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