scholarly journals Sarcopenia Should Reflect the Contribution of Age-Associated Changes in Skeletal Muscle to Risk of Morbidity and Mortality in Elderly People

2015 ◽  
Vol 16 (7) ◽  
pp. 546-547 ◽  
Author(s):  
William J. Evans
Keyword(s):  
Skeletal Muscle ◽  
Elderly People ◽  
Morbidity And Mortality

The place of beta-adrenoreceptor-blocking drugs in the treatment of congestive heart failure in elderly people: review of current opinion

1998 ◽  
Vol 8 (1) ◽  
pp. 89-92
Author(s):  
L Woosnam ◽  
M Hasan
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Angiotensin Converting Enzyme ◽  
Elderly People ◽  
Ace Inhibitors ◽  
Survival Benefit ◽  
Clinical Syndrome ◽  
Morbidity And Mortality ◽  
Converting Enzyme ◽  
Current Opinion

The clinical syndrome of heart failure affects more than 1% of the population, and its prevalence increases steeply with advancing age, especially after 75, where it reaches approximately 10%. It is one of the commonest reasons for the admission of elderly people to hospital.Despite recent advances in treatment of heart failure with angiotensin-converting enzyme (ACE) inhibitors, which were proven to provide survival benefit, the rates of morbidity and mortality from heart failure remain high, and new therapeutic strategie s are needed.

scholarly journals The Usage of Influenza Vaccine to Prevent Seasonal Influenza during Pandemic COVID-19

2021 ◽  
Vol 8 (2) ◽  
pp. 93
Author(s):  
Yelvi Levani ◽  
Ayu Lidya Paramita
Keyword(s):  
Influenza Virus ◽  
Influenza Vaccine ◽  
Elderly People ◽  
Seasonal Influenza ◽  
Morbidity And Mortality ◽  
Acute Respiratory Disease ◽  
Seasonal Flu ◽  
Airborne Disease ◽  
Live Attenuated Influenza Virus ◽  
Virus Influenza

Influenza is an acute respiratory disease caused by influenza virus. Influenza can affect million people in every year and causing morbidity. Some of cases can be severe and need hospitalized, especially in elderly people. Influenza is an airborne disease and can spread rapidly. Every seasonal flu can be different because Influenza virus do mutation. Influenza vaccine can reduce morbidity and mortality. There are two types of influenza vaccine; live attenuated influenza virus (LAIV) and inactivated influenza virus (IIV). The newest type of influenza vaccine consists four types of virus (quadrivalent), therefore it gives more protection compared to the older one. Influeza vaccine is still recommended during pandemic COVID-19 because it can prevent co-infection between Influenza and COVID-19. In addition, it can reduce the morbidity and mortality during pandemic COVID-19.

scholarly journals Risk Factors for COVID-19 Morbidity and Mortality in Institutionalised Elderly People

2021 ◽  
Vol 18 (19) ◽  
pp. 10221
Author(s):  
Ander Burgaña Agoües ◽  
Marta Serra Gallego ◽  
Raquel Hernández Resa ◽  
Beatriz Joven Llorente ◽  
Maria Lloret Arabi ◽  
...  
Keyword(s):  
Nursing Home ◽  
Nursing Homes ◽  
Elderly People ◽  
Barthel Index ◽  
Morbidity And Mortality ◽  
Test Results ◽  
Polymerase Chain ◽  
Home Workers ◽  
Adequate Management ◽  
Pcr Test

Background: SARS-CoV-2 has caused a high mortality in institutionalised individuals. There are very few studies on the involvement and the real impact of COVID-19 in nursing homes. This study analysed factors related to morbidity and mortality of COVID-19 in institutionalised elderly people. Methods: This cohort study included 842 individuals from 12 nursing homes in Sant Cugat del Vallès (Spain) from 15 March to 15 May 2020. We evaluated individual factors (demographic, dependence, clinical, and therapeutic) and those related to the nursing homes (size and staff) associated with infection and mortality by SARS-CoV-2. Infection was diagnosed by molecular biology test. Results: Of the 842 residents included in the analysis, 784 underwent a Polymerase Chain Reaction (PCR) test; 74.2% were women, the mean age was 87.1 years, and 11.1% died. The PCR test was positive in 44%. A total of 33.4% of the residents presented symptoms compatible with COVID-19 and of these, 80.9% were PCR-positive for SARS-CoV-2. Infection by SARS-CoV-2 among residents was associated with the rate of staff infected in the homes. Mortality by SARS-CoV-2 was related to male sex and a greater grade of dependence measured with the Barthel index. Conclusions: SARS-Cov-2 infection in institutionalised people is associated with the infection rate in nursing home workers and mortality by SARS-Cov-2 with sex and greater dependency according to the Barthel index. Adequate management of nursing home staff and special attention to measures of infection control, especially of individuals with greater dependence, are keys for successful management of future pandemic situations.

Rhabdomyolysis in Retrospect: Are Psychiatric Patients Predisposed to this Little-Known Syndrome?

1988 ◽  
Vol 17 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Steven B. Johnson ◽  
William A. Alvarez ◽  
Jack P. Freinhar
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Clinical Presentation ◽  
Psychiatric Patients ◽  
Morbidity And Mortality ◽  
Laboratory Findings ◽  
Skeletal Muscle Injury

Rhabdomyolysis is a potentially lethal syndrome that follows skeletal muscle injury, both traumatic and nontraumatic. The literature on this syndrome remains sketchy, and rhabdomyolysis may often go unrecognized. The history, clinical presentation, laboratory findings, etiology, and treatment of rhabdomyolysis are reviewed. Factors which predispose psychiatric patients in particular to this syndrome are discussed. Recommendations to reduce morbidity and mortality are offered.

scholarly journals Falls: a significant cause of morbidity and mortality in elderly people

2018 ◽  
Vol 64 (11) ◽  
pp. 1076-1083
Author(s):  
Marie Berková ◽  
Zdeněk Berka
Keyword(s):  
Elderly People ◽  
Morbidity And Mortality

Burn-induced hypermetabolism and skeletal muscle dysfunction

2021 ◽  
Author(s):  
Carly M Knuth ◽  
Christopher Auger ◽  
Marc G. Jeschke
Keyword(s):  
Skeletal Muscle ◽  
Wound Healing ◽  
Burn Injury ◽  
Improve Patient Care ◽  
Morbidity And Mortality ◽  
Muscle Dysfunction ◽  
Comprehensive Overview ◽  
Skeletal Muscle Function ◽  
Skeletal Muscle Dysfunction ◽  
Muscle Catabolism

Critical illnesses, including sepsis, cancer cachexia and burn injury, invoke a milieu of systemic metabolic and inflammatory derangements that ultimately results in increased energy expenditure leading to fat and lean mass catabolism. Burn injuries present a unique clinical challenge given the magnitude and duration of the hypermetabolic response in comparison to other forms of critical illness, which drastically increase the risk of morbidity and mortality. Skeletal muscle metabolism is particularly altered as a consequence of burn-induced hypermetabolism as it primarily provides a main source of fuel in support of wound healing. Interestingly, muscle catabolism is sustained long after the wound has healed, indicating that additional mechanisms beyond wound healing are involved. In this review, we discuss the distinctive pathophysiological response to burn injury with a focus on skeletal muscle function and metabolism. We first examine the diverse consequences on skeletal muscle dysfunction between thermal, electrical and chemical burns. We then provide a comprehensive overview of the known mechanisms underlying skeletal muscle dysfunction that may be attributed to hypermetabolism. Lastly, we review the most promising current treatment options to mitigate muscle catabolism, and by extension improve morbidity and mortality, and end with future directions which have the potential to significantly improve patient care.

Molecular Pathways Leading to Cancer Cachexia

Physiology ◽  
2005 ◽  
Vol 20 (5) ◽  
pp. 340-348 ◽  
Author(s):  
Michael J. Tisdale
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Cancer Cachexia ◽  
Host Factors ◽  
Morbidity And Mortality ◽  
Molecular Pathways

Loss of body weight in cancer patients strongly influences morbidity and mortality. Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue.

scholarly journals Prevalence of Sarcopenia and Related Factors of Skeletal Muscle Mass in Community-dwelling Frail Elderly People

2015 ◽  
Vol 30 (5) ◽  
pp. 793-796
Author(s):  
Yoshiharu NAGAI ◽  
Masami NAKAHARA ◽  
Takeyoshi SHIMODA ◽  
Yoshirou TAKANO
Keyword(s):  
Skeletal Muscle ◽  
Elderly People ◽  
Muscle Mass ◽  
Frail Elderly ◽  
Skeletal Muscle Mass ◽  
Community Dwelling ◽  
Related Factors ◽  
Frail Elderly People
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