scholarly journals Diabetes Results in Structural Alteration of Chondroitin Sulfate in the Urine

2013 ◽  
Vol 16 (3) ◽  
pp. 486 ◽  
Author(s):  
Tingting Zhao ◽  
Xiaoguang Lu ◽  
Neal M Davies ◽  
Yuewen Gong ◽  
Jingzhen Guo ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Chondroitin Sulfate ◽  
Chondroitin Sulphate ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Healthy Control ◽  
The Relationship

Purpose. The assessment of the clinical significance of chondroitin sulfate in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) for the detection of the relationship between chondroitin sulfate (CS) structure and disease. Methods. Healthy control (n=15), type 2 diabetic patients with normalbuminuria (n=12), and patients with microalbuminuria (n=13) were enrolled in the study. Total sulfated glycosaminoglycans (GAGs) concentration in the first morning urine was evaluated by 1,9-dimethylmethylene blue method and the composition was determined by agarose gel electrophoresis. Urinary chondroitin sulfate was quantified by a combination of treatment with specific lyase digestions and separation of products by SAX-HPLC. Results: GAGs concentration significantly increased in diabetic patients with microalbuminuria compared to diabetic patients with normalbuminuria. Qualitative analysis of urinary GAGs revealed the presence of chondroitin sulfate, heparan sulfate, and low-sulphated chondroitin sulphate-protein complex (LSC-PG). There was a decrease in CS and an increase in LSC-PG in the urine of patients with diabetes compared to healthy controls. Moreover, in diabetic patients, chondroitin sulfate contains more 6-sulfated disaccharide and less 4-sulfated disaccharide. There was a statistically significant difference in ratio of 6-sulfated disaccharide to 4-sulfated disaccharide among the three groups. Conclusions: GAGs were significantly increased in diabetic patients with microalbuminuria. The levels of urinary GAGs, ratio of LSC-PG/CS, as well as ratio of 6-sulfated to 4-sulfated disaccharides could be useful markers for diagnosis of patients with diabetic nephropathy.   This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Sleep Quality of Diabetic Patients with Metabolic Syndrome, Is There A Difference?

2020 ◽  
Author(s):  
Savas Karatas ◽  
Aysun Işıklar
Keyword(s):  
Metabolic Syndrome ◽  
Sleep Quality ◽  
Diabetic Patients ◽  
Poor Sleep ◽  
Type 2 Diabetic Patients ◽  
Subjective Sleep Quality ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Type 2 Diabetic

Poor sleep quality is a prevalent health problem among patients with diabetes. Metabolic syndrome (MetS) is common in type 2 diabetic patients and associated with morbidity and mortality. We aimed to investigate sleep quality among type 2 diabetes patients according to their metabolic syndrome status. This was an analysis of data collected from 189 adult type 2 diabetic patients. The patients divided into two groups (metabolic and non-metabolic) based on the presence of MetS. Anthropometric measurements, blood pressure, and serum glucose, lipid levels were collected. The Pittsburgh Sleep Quality Index (PSQI) calculated for all patients. There was no significant difference in subjective sleep quality scores between the two groups (p > 0.05). However, there was a significant difference in sleep latency scores between the two groups; the scores of patients with MetS were lower than those of patients without MetS (p = 0.010, p < 0.05).Sleep quality was low in 57.1% (n = 108) of patients with diabetes. Poor sleep is common among diabetic patients, but in this study, metabolic syndrome existence not associated with sleep quality in type 2 diabetic patients.

scholarly journals Lack of Association betweenTLR4Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Danfeng Peng ◽  
Jie Wang ◽  
Jiemin Pan ◽  
Rong Zhang ◽  
Shanshan Tang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Chinese Population ◽  
Diabetic Patients ◽  
Low Grade ◽  
Nucleotide Polymorphisms ◽  
Type 2 Diabetic Patients ◽  
Single Nucleotide ◽  
Patients With Diabetes ◽  
Low Grade Inflammation

Objective. Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whetherTLR4variants are associated with diabetic nephropathy in the Chinese population.Methods. Seven tagging single nucleotide polymorphisms (SNPs) ofTLR4based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients. Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy.Results. None of the SNPs and haplotypes showed significant association to diabetic nephropathy in our study. No association between the SNPs and quantitative traits was observed either.Conclusion. We concluded that common variants withinTLR4genes were not associated with diabetic nephropathy in the Chinese type 2 diabetes patients.

scholarly journals Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Liang Ma ◽  
Meihua Yan ◽  
Xiaomu Kong ◽  
Yongwei Jiang ◽  
Tingting Zhao ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Lower Risk ◽  
Genetic Model ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Multiple Covariates ◽  
Peripheral Leukocytes ◽  
The Relationship ◽  
Control Study

The aim of this study was to investigate the relationship between EPHX2 rs751141 (R287Q polymorphism) and diabetic nephropathy (DN) in Chinese type 2 diabetes (T2D). This case-control study explored the association between EPHX2 rs751141 and DN in a total of 870 Chinese T2D patients (406 T2D patients with DN and 464 T2D patients without DN). DNA was extracted from peripheral leukocytes of the patients and rs751141 was genotyped. The A allele frequency of rs751141 was significantly lower in DN patients (20.94%) compared with non-DN controls (27.8%) (P=0.001), and the A allele of rs751141 was associated with a significantly lower risk of DN after adjustment for multiple covariates in the additive genetic model (OR = 0.68, 95% CI = 0.52–0.88, P=0.004). Significant association between rs751141 and homocysteine (Hcy) level on the risk of DN was observed, indicating that in patients with the highest Hcy levels, the A allele showed marked association with lower risk of DN in all three genetic models. In conclusion, the A allele of exonic polymorphism in EPHX2 rs751141 is negatively associated with the incidence of DN in the Chinese T2D population, which could be modulated by Hcy level status.

scholarly journals The Relationship Between Nutrition Knowledge and Development of Complications in Type 2 Diabetic Patients

2016 ◽  
Vol 23 (4) ◽  
pp. 341-351 ◽  
Author(s):  
Deniz Korkut ◽  
Gul Ergor ◽  
Gulsah Kaner ◽  
Nilgun Seremet Kurklu
Keyword(s):  
Nutrition Education ◽  
Diabetic Foot ◽  
Eating Habits ◽  
Nutrition Knowledge ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
The Difference ◽  
The Relationship

Abstract Background and Aims: Diabetes is increasing rapidly in Turkey as most countries in the world. The prevention of complications which is the main aim in the treatment of diabetes can be accomplished partly with nutrition education. The aim of this study was to assess the relationship between nutrition knowledge (NK) and complications in patients with type 2 diabetes. Materials and Methods: 280 patients with 8-20 years of diabetes duration who applied to diet outpatient clinic were recruited. The questionnaire was prepared by the investigators to assess the NK. A score was calculated on the scale of 100. The complications were determined based on hospital records and patients’ selfreport. Results: 63.2% of participants were female and 36.8% were male. The most common complications in participants were retinopathy (56.1%) and neuropathy (42.9%). The mean NK score was 80.2±11.7. At least one complication was seen in 85.0% of the participants. There was no significant difference for having any complication in patients with adequate and inadequate NK. However the risk of diabetic foot, and coronary artery disease was significantly higher in women with inadequate NK. Conclusion: NK is quite high in long term diabetic patients. However no effect of the NK on the development of complications could be shown. The difference of effect between men and women could be due to the fact that food is mostly prepared by women thus not much chance of the knowledge of men to be reflected on his eating habits. The knowledge difference among female patients was seen in the results as; in women with inadequate NK, the prevalence of diabetic foot and CAD was significantly higher.

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