scholarly journals Synthetic and biological applications of tricyclic analogues of guanosine.

1996 ◽  
Vol 43 (1) ◽  
pp. 53-64 ◽  
Author(s):  
B Golankiewicz
Keyword(s):  
Conformational Analysis ◽  
Physical Properties ◽  
Graphical Method ◽  
Antiviral Agents ◽  
Amino Group ◽  
Biological Applications ◽  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy ◽  
Fluorescent Analogues

Tricyclic nucleosides incorporating the 9-oxo-imidazo [1,2-a]purine (1,N2-ethenoguanine) system, natural prototypes of which occur in tRNA(Phe) as nucleosides of the wyosine series, were used for synthetic, structural and biological purposes. 1,N2-(Prop-1-ene-1,2-diyl)guanosine derivatives used as intermediates allowed to enforce on guanosine the substitution at the N-3 position and at the N2 exo-amino group, not possible to be performed directly. Wyosine and 2'-deoxywyosine together with 4,5'-anhydro-4-desmethylwyosine and its congeners were used as, respectively, 100% anti and 100% syn conformation standards in a new graphical method for the syn-anti conformational analysis of nucleosides by 1D 1H NOE difference spectroscopy. Substitution at the appended third ring allowed to modify the biological and physical properties of antiviral agents acyclovir and ganciclovir, e.g. to develop their fluorescent analogues.

Conformational Analysis of 3′-Deoxy-β-D-Ribonucleosides Using 1D-noe Difference Spectroscopy

1997 ◽  
Vol 16 (4) ◽  
pp. 507-513
Author(s):  
Anil Kumar ◽  
S. B. Katti∗ ◽  
H. Rosemeyer ◽  
Frank Seela
Keyword(s):  
Conformational Analysis ◽  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy

Conformational Analysis of 3′-Deoxyribonucleosides using 1D-Noe Difference Spectroscopy

1996 ◽  
Vol 15 (10) ◽  
pp. 1595-1601 ◽  
Author(s):  
Anil Kumar ◽  
S. B. Katti ◽  
H. Rosemeyer ◽  
Frank Seela
Keyword(s):  
Conformational Analysis ◽  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy

Structure of Manasse's dimer fromendo-2-hydroxyepicamphor by NOE difference spectroscopy

1992 ◽  
Vol 30 (10) ◽  
pp. 996-999 ◽  
Author(s):  
Malcolm R. Banks ◽  
Ian Gosney ◽  
Keith J. Grant ◽  
David Reed ◽  
Philip K. G. Hodgson
Keyword(s):  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy

Zuordnung der 1H-NMR-Spektren von Depsiden, Depsidonen, Depsonen und Dibenzofuranen aus Flechten durch NOE-Differenzspektroskopie / Assignment of 1H NMR Spectra of Depsides, Depsidones, Depsones and Dibenzofurans from Lichens by NOE Difference Spectroscopy

1989 ◽  
Vol 44 (9) ◽  
pp. 1117-1123 ◽  
Author(s):  
Jasmin Jakupovic ◽  
Siegfried Huneck
Keyword(s):  
Methyl Ester ◽  
1H Nmr ◽  
Nmr Spectra ◽  
Usnic Acid ◽  
Acid Methyl Ester ◽  
Difference Spectroscopy ◽  
H Nmr ◽  
Acid Methyl ◽  
Lichen Substances ◽  
Noe Difference Spectroscopy

The 1H NMR spectra of the following lichen substances have been correlated by NOE difference spectroscopy: atranorin, barbatic acid, diffractaic acid, nephroarctin, perlatolic acid, planaic acid methyl ester, pseudocyphellarin A, sphaerophorin (depsides), hypoprotocetraric acid, lobaric acid, pannarin, physodalic acid, psoromic acid, stictic acid (depsidones), picrolichenic acid (depsone), di-O-methyl-pannaric acid dimethylester, pannaric acid, porphyrilic acid, schizopeltic acid, strepsilin, and usnic acid (dibenzofurans).

Quantum Dots Based Material for Drug Delivery Applications

2021 ◽  
pp. 191-215
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Particle Size ◽  
Physical Properties ◽  
Semiconductor Nanoparticles ◽  
Cellular Imaging ◽  
Biological Applications ◽  
Distinct Class ◽  
Imaging Probes ◽  
Biomedical Field

Quantum dots (QDs) have shown promising potential to many biomedical and biological applications, mainly in drug delivery or activation and cellular imaging. These semiconductor nanoparticles, QDs, whose particle size is in the range of 2-10 nanometer with unique photo-chemical and -physical properties that are not possessed by any other isolated molecules, have become one of the distinct class of imaging probes and worldwide platforms for manufacturing of multifunctional nanodevices. In this chapter, properties, applications of QDs, and importance in the biomedical field especially in drug delivery is presented.

scholarly journals Synthesis and Conformational Analysis of Fluorinated Uridine Analogues Provide Insight into a Neighbouring-Group Participation Mechanism

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5513
Author(s):  
Freideriki Michailidou ◽  
Tomas Lebl ◽  
Alexandra M. Z. Slawin ◽  
Sunil Vishnuprasadji Sharma ◽  
Murray J. B. Brown ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Antiviral Agents ◽  
Synthetic Methods ◽  
Nucleoside Analogues ◽  
Mechanism Of Formation ◽  
Group Participation ◽  
Enzymatic Function ◽  
Neighbouring Group Participation ◽  
Sn2 Pathway ◽  
Insight Into

Fluorinated nucleoside analogues have attracted much attention as anticancer and antiviral agents and as probes for enzymatic function. However, the lack of direct synthetic methods, especially for 2′,3′-dideoxy-2′,3′-difluoro nucleosides, hamper their practical utility. In order to design more efficient synthetic methods, a better understanding of the conformation and mechanism of formation of these molecules is important. Herein, we report the synthesis and conformational analysis of a 2′,3′-dideoxy-2′,3′-difluoro and a 2′-deoxy-2′-fluoro uridine derivative and provide an insight into the reaction mechanism. We suggest that the transformation most likely diverges from the SN1 or SN2 pathway, but instead operates via a neighbouring-group participation mechanism.

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