Syn-anti conformational analysis of regular and modified nucleosides by 1D 1H NOE difference spectroscopy: a simple graphical method based on conformationally rigid molecules

1990 ◽  
Vol 55 (22) ◽  
pp. 5784-5790 ◽  
Author(s):  
Helmut Rosemeyer ◽  
Gabor Toth ◽  
Bozenna Golankiewicz ◽  
Zygmunt Kazimierczuk ◽  
Werner Bourgeois ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Graphical Method ◽  
Modified Nucleosides ◽  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy

scholarly journals Synthetic and biological applications of tricyclic analogues of guanosine.

1996 ◽  
Vol 43 (1) ◽  
pp. 53-64 ◽  
Author(s):  
B Golankiewicz
Keyword(s):  
Conformational Analysis ◽  
Physical Properties ◽  
Graphical Method ◽  
Antiviral Agents ◽  
Amino Group ◽  
Biological Applications ◽  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy ◽  
Fluorescent Analogues

Tricyclic nucleosides incorporating the 9-oxo-imidazo [1,2-a]purine (1,N2-ethenoguanine) system, natural prototypes of which occur in tRNA(Phe) as nucleosides of the wyosine series, were used for synthetic, structural and biological purposes. 1,N2-(Prop-1-ene-1,2-diyl)guanosine derivatives used as intermediates allowed to enforce on guanosine the substitution at the N-3 position and at the N2 exo-amino group, not possible to be performed directly. Wyosine and 2'-deoxywyosine together with 4,5'-anhydro-4-desmethylwyosine and its congeners were used as, respectively, 100% anti and 100% syn conformation standards in a new graphical method for the syn-anti conformational analysis of nucleosides by 1D 1H NOE difference spectroscopy. Substitution at the appended third ring allowed to modify the biological and physical properties of antiviral agents acyclovir and ganciclovir, e.g. to develop their fluorescent analogues.

Conformational Analysis of 3′-Deoxy-β-D-Ribonucleosides Using 1D-noe Difference Spectroscopy

1997 ◽  
Vol 16 (4) ◽  
pp. 507-513
Author(s):  
Anil Kumar ◽  
S. B. Katti∗ ◽  
H. Rosemeyer ◽  
Frank Seela
Keyword(s):  
Conformational Analysis ◽  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy

Conformational Analysis of 3′-Deoxyribonucleosides using 1D-Noe Difference Spectroscopy

1996 ◽  
Vol 15 (10) ◽  
pp. 1595-1601 ◽  
Author(s):  
Anil Kumar ◽  
S. B. Katti ◽  
H. Rosemeyer ◽  
Frank Seela
Keyword(s):  
Conformational Analysis ◽  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy

Ribose-Modified Nucleosides as Ligands for Adenosine Receptors:  Synthesis, Conformational Analysis, and Biological Evaluation of 1‘-C-Methyl Adenosine Analogues

2002 ◽  
Vol 45 (6) ◽  
pp. 1196-1202 ◽  
Author(s):  
Loredana Cappellacci ◽  
Grazia Barboni ◽  
Micaela Palmieri ◽  
Michela Pasqualini ◽  
Mario Grifantini ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Adenosine Receptors ◽  
Biological Evaluation ◽  
Modified Nucleosides ◽  
Adenosine Analogues

Structure of Manasse's dimer fromendo-2-hydroxyepicamphor by NOE difference spectroscopy

1992 ◽  
Vol 30 (10) ◽  
pp. 996-999 ◽  
Author(s):  
Malcolm R. Banks ◽  
Ian Gosney ◽  
Keith J. Grant ◽  
David Reed ◽  
Philip K. G. Hodgson
Keyword(s):  
Difference Spectroscopy ◽  
Noe Difference Spectroscopy

Zuordnung der 1H-NMR-Spektren von Depsiden, Depsidonen, Depsonen und Dibenzofuranen aus Flechten durch NOE-Differenzspektroskopie / Assignment of 1H NMR Spectra of Depsides, Depsidones, Depsones and Dibenzofurans from Lichens by NOE Difference Spectroscopy

1989 ◽  
Vol 44 (9) ◽  
pp. 1117-1123 ◽  
Author(s):  
Jasmin Jakupovic ◽  
Siegfried Huneck
Keyword(s):  
Methyl Ester ◽  
1H Nmr ◽  
Nmr Spectra ◽  
Usnic Acid ◽  
Acid Methyl Ester ◽  
Difference Spectroscopy ◽  
H Nmr ◽  
Acid Methyl ◽  
Lichen Substances ◽  
Noe Difference Spectroscopy

The 1H NMR spectra of the following lichen substances have been correlated by NOE difference spectroscopy: atranorin, barbatic acid, diffractaic acid, nephroarctin, perlatolic acid, planaic acid methyl ester, pseudocyphellarin A, sphaerophorin (depsides), hypoprotocetraric acid, lobaric acid, pannarin, physodalic acid, psoromic acid, stictic acid (depsidones), picrolichenic acid (depsone), di-O-methyl-pannaric acid dimethylester, pannaric acid, porphyrilic acid, schizopeltic acid, strepsilin, and usnic acid (dibenzofurans).

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