Quantitative Ultrasound Molecular Imaging in Large Blood Vessel Environments

2016 ◽  
Author(s):  
Shiying Wang
Keyword(s):  
Molecular Imaging ◽  
Blood Vessel ◽  
Quantitative Ultrasound ◽  
Large Blood Vessel ◽  
Ultrasound Molecular Imaging

Quantitative ultrasound molecular imaging by modeling the binding kinetics of targeted contrast agent

2017 ◽  
Vol 62 (6) ◽  
pp. 2449-2464 ◽  
Author(s):  
Simona Turco ◽  
Isabelle Tardy ◽  
Peter Frinking ◽  
Hessel Wijkstra ◽  
Massimo Mischi
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Quantitative Ultrasound ◽  
Binding Kinetics ◽  
Ultrasound Molecular Imaging ◽  
Kinetics Of ◽  
Targeted Contrast Agent

Quantitative Ultrasound Molecular Imaging

2015 ◽  
Vol 41 (9) ◽  
pp. 2478-2496 ◽  
Author(s):  
James Shue-Min Yeh ◽  
Charles A. Sennoga ◽  
Ellen McConnell ◽  
Robert Eckersley ◽  
Meng-Xing Tang ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Quantitative Ultrasound ◽  
Ultrasound Molecular Imaging

Ultrasound molecular imaging-guided tumor gene therapy through dual-targeted cationic microbubbles

2021 ◽  
Vol 9 (7) ◽  
pp. 2454-2466
Author(s):  
Yingying Liu ◽  
Yuli Zhou ◽  
Jinfeng Xu ◽  
Hui Luo ◽  
Yao Zhu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Molecular Imaging ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Tumor Gene Therapy ◽  
Ultrasound Molecular Imaging ◽  
Tumor Gene

A novel dual-targeted cationic microbubbles help to improve gene transfection efficiency.

scholarly journals The Impact of Lipid Handling and Phase Distribution on the Acoustic Behavior of Microbubbles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 119
Author(s):  
Simone A.G. Langeveld ◽  
Inés Beekers ◽  
Gonzalo Collado-Lara ◽  
Antonius F. W. van der Steen ◽  
Nico de Jong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
High Speed ◽  
Phase Distribution ◽  
Direct Method ◽  
Ultrasound Contrast Agents ◽  
Lipid Phase ◽  
Acoustic Behavior ◽  
Ultrasound Molecular Imaging ◽  
The Impact

Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the acoustic behavior of microbubbles. Cholesterol was used to modify the lateral molecular packing of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)-based microbubbles. To assess the effect of lipid handling, microbubbles were produced by a direct method, i.e., lipids directly dispersed in an aqueous medium or indirect method, i.e., lipids first dissolved in an organic solvent. The lipid phase and ligand distribution in the microbubble coating were investigated using confocal microscopy, and the acoustic response was recorded with the Brandaris 128 ultra-high-speed camera. In microbubbles with 12 mol% cholesterol, the lipids were miscible and all in the same phase, which resulted in more buckle formation, lower shell elasticity and higher shell viscosity. Indirect DSPC microbubbles had a more uniform response to ultrasound than direct DSPC and indirect DSPC-cholesterol microbubbles. The difference in lipid handling between direct and indirect DSPC microbubbles significantly affected the acoustic behavior. Indirect DSPC microbubbles are the most promising candidate for ultrasound molecular imaging and drug delivery applications.

Designed Ankyrin Repeat Proteins as Novel Binders for Ultrasound Molecular Imaging

2021 ◽  
Author(s):  
Alexandra Kosareva ◽  
Mukesh Punjabi ◽  
Amanda Ochoa-Espinosa ◽  
Lifen Xu ◽  
Jonas V. Schaefer ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Ankyrin Repeat ◽  
Repeat Proteins ◽  
Ultrasound Molecular Imaging ◽  
Ankyrin Repeat Proteins
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