Detection of Microalbuminuria by Rocket Electrophoresis in Patients Suffering from Diabetes Mellitus with Soft Tissue Infections

2014 ◽  
Vol 2 (2) ◽  
pp. 32-38
Author(s):  
SN Tayde ◽  
◽  
YS Thakkar ◽  
Anil S Rahule ◽  
MK Tabhane ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Soft Tissue Infections ◽  
Rocket Electrophoresis

scholarly journals Group B Streptococcal infections among nonpregnant adults: A cross sectional study from a Tertiary care teaching hospital in South India

2021 ◽  
Vol 7 (4) ◽  
pp. 274-278
Author(s):  
Rosmi Jose ◽  
Ann George ◽  
Sathiavathy K A ◽  
Chithra Valsan
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Antibiotic Susceptibility ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Soft Tissue Infections ◽  
Streptococcal Infections ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group B

To understand the epidemiology of Group B Streptococcal infections among nonpregnant adults and to study the antibiotic susceptibility profile of GBS isolates.: A cross sectional study conducted in the department of microbiology in a tertiary care teaching hospital during December 2018 to May 2020. Group B Streptococcal (GBS) isolates from clinical samples of nonpregnant adults were included in the study. Identification and antibiotic susceptibility testing of GBS isolates were performed according to standard microbiology techniques. Patient’s demographic features and clinical details were collected from medical records. : A total of 58 GBS isolates were obtained from nonpregnant adults during the study period. There was a female (60.3%) predominance among the study group. Mean age of the study subjects was 51.4 years. In our study GBS were commonly isolated from urine 50% (n=29) and wound swabs 46.6% (n=27). One isolate each (1.7%) was obtained from blood culture, urethral swab and high vaginal swab. Common GBS infections noted in this study were Urinary tract infections (50%) and skin and soft tissue infections (46.6%). Diabetes mellitus (58.6%) was the most common risk factor noted in our study. All the isolates were sensitive to Penicillin, Linezolid and Vancomycin. Erythromycin and clindamycin resistance of 13.8% and 6.9% respectively were noted. A shifting trend of GBS infections from pregnant women and neonates to non-pregnant adults was observed in the present study. In patients with diabetes mellitus GBS could be considered as causative agent of skin and soft tissue infections.

scholarly journals Management of bacterial skin and soft tissue infections

2020 ◽  
pp. 89-107
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Diseases ◽  
Soft Tissue ◽  
Metabolic Diseases ◽  
Systemic Infection ◽  
Soft Tissue Infections ◽  
Medical Consultations ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Skin and soft tissue infections (SSTIs) are a group of diseases usually caused by bacteria, and connected with different clinical picture, course, and prognosis. The increasing incidence of SSTIs is associated mainly with aging of the population, the increasing number of metabolic diseases, especially diabetes mellitus, as well as cardiovascular diseases. Although SSTIs are often benign and usually does not require medical consultations, some of them may cause a systemic infection. In this situation, knowledge of the principles of diagnostic work-up and therapy is essential. The principles of recognition and treatment of skin and soft tissue infections, including new biocidal drugs, are presented.

scholarly journals Melioidosis in the Philippines

2018 ◽  
Vol 3 (3) ◽  
pp. 99
Author(s):  
Peter San Martin ◽  
Joseph Chua ◽  
Ralph Bautista ◽  
Jennifer Nailes ◽  
Mario Panaligan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Mortality Rate ◽  
Surveillance System ◽  
Case Series ◽  
The Philippines ◽  
Soft Tissue Infections ◽  
Intensive Phase ◽  
Co Morbidity ◽  
Tertiary Hospitals

The first documented case of melioidosis in the Philippines occurred in 1948. Since then, there have been sporadic reports in the literature about travelers diagnosed with melioidosis after returning from the Philippines. Indigenous cases, however, have been documented rarely, and under-reporting is highly likely. This review collated all Philippine cases of melioidosis published internationally and locally, as well as unpublished case series and reports from different tertiary hospitals in the Philippines. In total, 25 papers and 41 cases were identified. Among these, 23 were indigenous cases (of which 20 have not been previously reported in the literature). The most common co-morbidity present was diabetes mellitus, and the most common presentations were pulmonary and soft tissue infections. Most of the cases received ceftazidime during the intensive phase, while trimethoprim-sulfamethoxazole was given during the eradication phase. The known mortality rate was 14.6%, while 4.9% of all cases were reported to have had recurrence. The true burden of melioidosis in the country is not well defined. A lack of awareness among clinicians, a dearth of adequate laboratories, and the absence of a surveillance system for the disease are major challenges in determining the magnitude of the problem.

Soft Tissue Infections: Necrotizing or Toxigenic

2012 ◽  
Author(s):  
John W. Wilson ◽  
Lynn L. Estes
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Major Trauma ◽  
High Index ◽  
Immunocompromised Patients ◽  
Obese Patients ◽  
Soft Tissue Infections ◽  
Patients With Diabetes ◽  
Necrotizing Soft Tissue Infections ◽  
High Index Of Suspicion

• A high index of suspicion is critical in the diagnosis of necrotizing or toxigenic soft tissue infections.• Minor or major trauma can predispose patients to necrotizing soft tissue infections, which are more common in obese patients, patients with diabetes mellitus, and immunocompromised patients....

P1019CANAGLIFLOZIN AND RISK OF SKIN AND SOFT TISSUE INFECTIONS IN PEOPLE WITH DIABETES MELLITUS AND KIDNEY DISEASE - A POST-HOC ANALYSIS OF THE CREDENCE TRIAL

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Amy Kang ◽  
Brendan Smyth ◽  
Brendon Neuen ◽  
Hiddo Lambers Heerspink ◽  
Gian Luca Di Tanna ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Kidney Disease ◽  
Skin Infections ◽  
Soft Tissue Infections ◽  
Post Hoc Analysis ◽  
Intention To Treat ◽  
Post Hoc ◽  
Treat Population

Abstract Background and Aims The skin’s hypertonic microenvironment has a hypothesized protective antimicrobial function that may be disrupted by SGLT2i. The association between sodium glucose cotransporter inhibitors (SGLT2i) and genital mycotic infections is well established, but it is not known if these agents increase the risk of other skin and soft tissue infections (SSTI). We aimed to describe SSTI in the CREDENCE trial, and determine whether canagliflozin affects the risk of skin and soft tissue infections (SSTIs) overall and in subgroups. Method We performed a post-hoc analysis of the CREDENCE trial that randomised people with type 2 diabetes and albuminuric stage 2 and 3 chronic kidney disease to either canagliflozin 100mg daily or placebo. Infections reported as adverse events were assessed by two blinded authors following predetermined criteria for SSTI with discrepancies resolved by consensus. We analysed the risks of SSTIs in the on-treatment population as the more conservative approach, with a sensitivity analysis conducted in the intention-to-treat population. Univariable time-to first-event regression models were assessed. Results Overall 373/4397 (8.5%) participants experienced 478 events comprising 252 bacterial skin infections (including 2 episodes of necrotising fasciitis), 94 fungal skin infections, 109 other skin infections and 23 soft tissue infections. Of these, 136/478 (28%) were serious. Drug was continued in 290/373 (78%) of first events, with similar frequency of subsequent events between groups (31/133 (23%) and 33/157 (21%) for those continuing canagliflozin and placebo respectively). In both cases of necrotising fasciitis, drug was withdrawn and the participants recovered.Canagliflozin did not increase the risk of SSTI (HR 0.85 [95% Confidence Interval (CI) 0.69-1.04] p=0.11) (Figure 1). Results were similar in the intention-to-treat population (HR 0.88 [95% CI 0.73-1.07] p=0.20), in analyses confined to serious SSTI (HR 0.83 [95% CI 0.58-1.21] p=0.33), and in the predefined subgroups. Conclusion Although other studies suggest that SGLT2i may reduce the sodium content of the skin, we found that canagliflozin does not increase the risk of skin and soft tissue infections, overall or in any subgroup, in people with type 2 diabetes mellitus and albuminuric chronic kidney disease.

scholarly journals A Comparison of Pathogens in Skin and Soft Tissue Infections and Pedal Osteomyelitis in Puncture Wound Injuries Affecting the Foot

2020 ◽  
Author(s):  
David H Truong ◽  
Javier La Fontaine ◽  
Matthew Malone ◽  
Dane K Wukich ◽  
Kathryn E Davis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Bacterial Pathogen ◽  
Soft Tissue Infections ◽  
Puncture Wound ◽  
Common Pathogen ◽  
Patients With Diabetes

ObjectiveTo compare pathogens involved in skin and soft tissue infection (SSTI) and pedal osteomyelitis (OM) in patients with and without diabetes with puncture wounds to the foot. MethodsWe evaluated 113 consecutive patients between June 2011 and March 2019 with foot infection (SSTI and OM) from a puncture injury sustained to the foot. Eighty-three patients had diabetes (DM) and 30 did not (NDM). We evaluated the bacterial pathogens in patients with skin and soft tissue infections (SSTI) and pedal osteomyelitis (OM). ResultsPolymicrobial infection were more common in patients with diabetes mellitus (83.1% vs 53.3%, p=.001). The most common pathogen for SSTI and OM in DM was s. aureus (SSTI 50.7%, OM 32.3%), whereas in NDM patients it was Pseudomonas (25%) for SSTI. Anaerobes (9.4%) and fungal (3.1%) infection were uncommon. Pseudomonas aeruginosa was only identified in 5.8% of people with diabetes. ConclusionsThe most common bacterial pathogen in both SSTIs and pedal OM was staphylococcus aureus in patients with DM. Pseudomonas spp., was the most common pathogen in people without diabetes with SSTIs.

scholarly journals Necrotizing Soft Tissue Infections in the Vasculopathic Patient: Review of Literature

2020 ◽  
Vol 104 (1-2) ◽  
pp. 75-88
Author(s):  
Chi Lap Nicholas Tsang ◽  
Jerry Cao ◽  
Prashanth Gunanayagam ◽  
Rui Feitosa ◽  
Andrew Bullen
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Peripheral Arterial Disease ◽  
Disease Patient ◽  
Arterial Disease ◽  
Mortality Rates ◽  
Future Research ◽  
Soft Tissue Infections ◽  
Necrotizing Soft Tissue Infections ◽  
Peripheral Arterial

Background: Necrotizing soft tissue infection is a surgical emergency associated with high mortality. Its presence in patients with risk factors for peripheral arterial disease such as diabetes mellitus is consistently associated with significantly poorer outcomes. Though it has been over a century since it was initially described in the literature, mortality rates remain high and treatment regimens are not standardized. Materials and methods: PubMed and Cochrane databases were searched for articles pertaining to necrotizing soft tissue infections. Articles were screened for relevance with the intent to compare outcomes in prospective studies of patients with diabetes mellitus or peripheral arterial disease. Patient demographics, clinical findings, mortality, rates of amputation, and morbidity were intended to be compared. Results: 857 articles were identified, 165 duplicates were removed, and 6 prospective trials were identified for inclusion. Due to significant paucity of data, patient heterogeneity, and lack of standardization for surgical management, a descriptive review of the literature in relation to necrotizing soft tissue infections was pursued, with a focus on high-risk patients with peripheral arterial disease or diabetes mellitus. Conclusions: Early aggressive surgical intervention or major amputation may reduce mortality at the cost of increased disability and poorer quality of life in the long term, and may be appropriate in vasculopaths with poorly controlled diabetes and rapidly progressive fulminant infection. However, there is a deficiency in high-level evidence supporting surgical decision-making in this setting, with no standardized protocols for amputation. Future research will be needed to clarify the patient population who would benefit from radical amputation versus intention for limb salvage.

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