scholarly journals The Effects of Losartan on Lipid Peroxidation and the Antioxidant System in the Bone Tissue of Diabetic Rats

2019 ◽  
Author(s):  
Nihal ÖZTÜRK ERBOĞA ◽  
Semir ÖZDEMİR ◽  
Barış Özgür DÖNMEZ ◽  
Nurettin OĞUZ
Keyword(s):  
Lipid Peroxidation ◽  
Bone Tissue ◽  
Antioxidant System ◽  
Diabetic Rats

Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Mursel Bicer ◽  
Saltuk Bugra Baltaci ◽  
Suleyman Patlar ◽  
Rasim Mogulkoc ◽  
Abdulkerim Kasim Baltaci
Keyword(s):  
Lipid Peroxidation ◽  
Bone Tissue ◽  
G Protein ◽  
Cell Damage ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Male Rats ◽  
Swimming Exercise ◽  
Control Group ◽  
Sprague Dawley

AbstractAimThe present study aimed to examine the effects of melatonin supplementation on lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise.MethodsThe study was conducted on 80 Sprague-Dawley type adult male rats which were equally allocated to eight groups: group 1, general control; group 2, melatonin-supplemented control; group 3, melatonin-supplemented diabetic control; group 4, swimming control; group 5, melatonin-supplemented swimming; group 6, melatonin-supplemented diabetic swimming; group 7, diabetic swimming; group 8, diabetic control. In order to induce diabetes, the animals were subcutaneously injected with 40 mg/kg streptozotocin (STZ). The animals were supplemented with 3 mg/kg/day melatonin intraperitoneally (IP) for 4 weeks. At the end of the study, the animals were decapitated to collect bone tissue samples which were examined to find out the malondialdehyde (MDA) (nmol/g/protein) and glutathione (GSH) (mg/dL/g protein) levels.ResultsThe highest MDA values in the bone tissue were found in groups 7 and 8. MDA levels in the bone tissue in groups 3 and 6 were lower than the levels in groups 7 and 8, but higher than those in all other groups. Groups 3, 5 and 6 had the highest bone tissue GSH values. On the other hand, the lowest GSH level was established in groups 7 and 8.ConclusionThe results of the present study indicated that the cell damage caused by acute swimming exercise and diabetes in the bone tissue could be prevented by melatonin supplementation.

scholarly journals Оцінка впливу остеотропних препаратів на активність процесів пероксидного окиснення ліпідів та антиоксидантної системи при регенерації кісткової тканини в експерименті

2018 ◽  
Author(s):  
V. M. Zubachyk ◽  
I. V. Han ◽  
O. O. Pasko
Keyword(s):  
Lipid Peroxidation ◽  
Bone Tissue ◽  
Antioxidant System ◽  
Tricalcium Phosphate ◽  
Antioxidant Properties ◽  
Malonic Dialdehyde ◽  
Endodontic Treatment ◽  
White Rats ◽  
Biochemical Studies ◽  
Regeneration Of Bone Tissue

Summary. The comparative estimation of the dynamics of the reparative process in bone tissue under the infl uence of MTA and Nano Gen preparations and the proposed compositions based on hydroxyapatite and β-tricalcium phosphate for endodontic treatment is given.The aim of the study – to determine the dynamics of reparative processes in bone tissue under the infl uence of drugs and compositions for endodontic treatment, which is based on the analysis of the results of biochemical studies of lipid peroxidation and antioxidant system.Materials and Methods. The experiment was conducted on 120 white rats, on which the defect of bone tissue was created and fi lled with the studied biomaterials. From the experiment the animals were excised at 14 and 30 days by decapitation under anesthesia and blood samples were taken for biochemical studies. In the blood of rats, the activity of peroxide oxidation processes of lipids – malonic dialdehyde and antioxidant system enzymes – catalase and superoxide dismutase were studied.Results and Discussion. In animal groups where hydroxyapatite and β-tricalcium phosphate based compositions were used, less activity was observed in lipoperoxidation than in animals using MTA and Nano Gen. The proposed compositions possess antioxidant properties that contribute to the reduction of the activity of the infl ammatory process. Compositions based on hydroxyapatite and β-tricalcium phosphate at earlier times restore the balance in the lipid peroxidation system and the antioxidant system, which creates more favorable conditions for biorevitalization and regeneration of non-apical tissues.Conclusions. The compositions based on hydroxyapatite and β-tricalcium phosphate possess antioxidant properties, suppress excessive lipoproxidation processes, contribute to the reduction of the activity of the infl ammatory process, which stimulates the regeneration of bone tissue.

scholarly journals Amelioration of lipid peroxidation in vivo and in vitro by Satureja khozestanica essential oil in alloxan-induced diabetic rats

2014 ◽  
Vol 13 (1) ◽  
Author(s):  
Hassan Ahmadvand ◽  
Majid Tavafi ◽  
Ali Khosrowbeygi ◽  
Gholamreza Shahsavari ◽  
Maryam Hormozi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Essential Oil ◽  
Diabetic Rats

scholarly journals Oxidative Stress in Rats After 60 Days of Hypergalactosemia or Hyperglycemia

2003 ◽  
Vol 22 (6) ◽  
pp. 423-427 ◽  
Author(s):  
Mary Otsyula ◽  
Matthew S. King ◽  
Tonya G. Ketcham ◽  
Ruth A. Sanders ◽  
John B. Watkins
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Insulin Treatment ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Glutathione Disulfide ◽  
Hepatic Lipid Peroxidation ◽  
Streptozotocin Diabetic Rats

Two of the models used in current diabetes research include the hypergalactosemic rat and the hyperglucosemic, streptozotocin-induced diabetic rat. Few studies, however, have examined the concurrence of these two models regarding the effects of elevated hexoses on biomarkers of oxidative stress. This study compared the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase and the concentrations of glutathione, glutathione disulfide, and thiobarbituric acid reactants (as a measure of lipid peroxidation) in liver, kidney, and heart of Sprague-Dawley rats after 60 days of either a 50% galactose diet or insulin deficiency caused by streptozotocin injection. Most rats from both models developed bilateral cataracts. Blood glucose and glycosy-lated hemoglobin A1c concentrations were elevated in streptozotocin diabetic rats. Streptozotocin diabetic rats exhibited elevated activities of renal superoxide dismutase, cardiac catalase, and renal and cardiac glutathione peroxidase, as well as elevated hepatic lipid peroxidation. Insulin treatment of streptozotocin-induced diabetic rats normalized altered markers. In galactosemic rats, hepatic lipid peroxidation was increased whereas glutathione reductase activity was diminished. Glutathione levels in liver were decreased in diabetic rats but elevated in the galactosemic rats, whereas hepatic glutathione disulfide concentrations were decreased much more in diabetes than in galactosemia. Insulin treatment reversed/prevented all changes caused by streptozotocin-induced diabetes. Lack of concomitance in these data indicate that the 60-day galactose-fed rat is not experiencing the same oxidative stress as the streptozotocin diabetic rat, and that investigators must be cautious drawing conclusions regarding the concurrence of the effects of the two animal models on oxidative stress biomarkers.

Supplementation of coenzyme Q10 and α-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats

2008 ◽  
Vol 28 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Cristina M. Sena ◽  
Elsa Nunes ◽  
Aline Gomes ◽  
Maria S. Santos ◽  
Teresa Proença ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Coenzyme Q10 ◽  
Glycated Hemoglobin ◽  
Diabetic Rats ◽  
Hemoglobin Level ◽  
Glycated Hemoglobin Level

Attenuation of erythrocyte membrane oxidative stress bySesbania grandiflorain streptozotocin-induced diabetic rats

2015 ◽  
Vol 93 (4) ◽  
pp. 385-395 ◽  
Author(s):  
Chandrabose Sureka ◽  
Thiyagarajan Ramesh ◽  
Vavamohaideen Hazeena Begum
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Blood Glucose ◽  
Erythrocyte Membrane ◽  
Osmotic Fragility ◽  
Diabetic Rats ◽  
Glycosylated Haemoglobin ◽  
Albino Rats ◽  
Enzymatic Antioxidants ◽  
Protective Effects

The aim of the present study was to investigate the protective effects of Sesbania grandiflora flower (SGF) extract on erythrocyte membrane in Streptozotocin (STZ)-induced diabetic rats. Adult male albino rats of Wistar strain, weighing 190–220 g, were made diabetic by an intraperitonial administration of STZ (45 mg/kg). Normal and diabetic rats were treated with SGF, and diabetic rats were also treated with glibenclamide as drug control, for 45 days. In this study plasma insulin and haemoglobin levels were decreased and blood glucose, glycosylated haemoglobin, protein oxidation, lipid peroxidation markers, and osmotic fragility levels were increased in diabetic rats. Moreover, erythrocytes antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxide, glutathione reductase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase activities and non-enzymatic antioxidants such as vitamin C, vitamin E, reduced glutathione (GSH), and oxidized glutathione (GSSG) levels were altered. Similarly, the activities of total ATPases, Na+/K+-ATPase, Ca2+-ATPase, and Mg2+-ATPase were also decreased in the erythrocytes of diabetic rats. Administration of SGF to STZ-induced diabetic rats reduced blood glucose and glycosylated haemoglobin levels with increased levels of insulin and haemoglobin. Moreover, SGF reversed the protein and lipid peroxidation markers, osmotic fragility, membrane-bound ATPases activities, and antioxidant status in STZ-induced diabetic rats. These results suggest that SGF could provide a protective effect on diabetes by decreasing oxidative stress-associated diabetic complications.

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