Supplementation of coenzyme Q10 and α-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats

2008 ◽  
Vol 28 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Cristina M. Sena ◽  
Elsa Nunes ◽  
Aline Gomes ◽  
Maria S. Santos ◽  
Teresa Proença ◽  
...  
2018 ◽  
Vol 65 (1) ◽  
pp. 121-127 ◽  
Author(s):  
Hideaki Kurosawa ◽  
Yoshifumi Saisho ◽  
Koichi Fukunaga ◽  
Mizuha Haraguchi ◽  
Wakako Yamasawa ◽  
...  

Angiology ◽  
2015 ◽  
Vol 67 (4) ◽  
pp. 384-390 ◽  
Author(s):  
Süleyman Karakoyun ◽  
Tayyar Gökdeniz ◽  
Mustafa Ozan Gürsoy ◽  
İbrahim Rencüzoğulları ◽  
Yavuz Karabağ ◽  
...  

Circulation ◽  
2004 ◽  
Vol 110 (4) ◽  
pp. 466-470 ◽  
Author(s):  
Lone Jørgensen ◽  
Trond Jenssen ◽  
Oddmund Joakimsen ◽  
Ivar Heuch ◽  
Ole Christian Ingebretsen ◽  
...  

2010 ◽  
Vol 30 (9) ◽  
pp. 1246-1255 ◽  
Author(s):  
Wei Zhu ◽  
Ying-Hua Li ◽  
Min-Li Chen ◽  
Fu-Liang Hu

Diabetes mellitus promoted an overproduction of free radicals and an increased incidence of both diabetic nephropathy and liver disease. In this report, we evaluated the effects of Chinese and Brazilian propolis on streptozotocin-induced hepatorenal injury in rats. The results demonstrated that Chinese propolis-treated rats had a 7.4% reduction in the glycated hemoglobin (HbAlc) level compared with untreated diabetic rats. Additionally, Chinese propolis induced an increase in the serum superoxide dismutase (SOD) level significantly while Brazilian propolis raised serum SOD and reduced level of malonaldehyde (MDA) and nitric synthetase (NOS). Of the measurable decrease in serum alanine transaminase (ALT), aspartate transaminase (AST) and microalbuminuria demonstrated the propolis-mediated improvement of hepatorenal function, which was further confirmed by histological examination. We also observed that Chinese and Brazilian propolis increased hepatorenal glutathione peroxidase (GSH-px) level and inhibited MDA production significantly. These results suggested that propolis may prevent hepatorenal injury by inhibiting lipid peroxidation and enhancing the activities of antioxidant enzymes.


Sign in / Sign up

Export Citation Format

Share Document