scholarly journals Design, Chemical Synthesis and Evaluation of Antimicrobial Activity Peptide Conjugates of Lactoferricin Analogues and Antibiotics

2018 ◽  
Author(s):  
Natalia Ptaszynska ◽  
Katarzyna Olkiewicz ◽  
Joanna Okonska ◽  
Anna Łegowska ◽  
Katarzyna Gucwa ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Synthesis ◽  
Peptide Conjugates

Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, and evaluation of antimicrobial activity and mammalian cytotoxicity

Peptides ◽  
2019 ◽  
Vol 117 ◽  
pp. 170079 ◽  
Author(s):  
Natalia Ptaszyńska ◽  
Katarzyna Olkiewicz ◽  
Joanna Okońska ◽  
Katarzyna Gucwa ◽  
Anna Łęgowska ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Synthesis ◽  
Peptide Conjugates

scholarly journals Chemical synthesis of polysaccharide–protein and polysaccharide–peptide conjugates: A review

2021 ◽  
Vol 274 ◽  
pp. 118662
Author(s):  
Yang Zhou ◽  
Stella P. Petrova ◽  
Kevin J. Edgar
Keyword(s):  
Chemical Synthesis ◽  
Peptide Conjugates

Effect of Low Charge and High Hydrophobicity on Antimicrobial Activity of the Quinazolinone-Peptide Conjugates

2018 ◽  
Vol 44 (2) ◽  
pp. 158-164 ◽  
Author(s):  
Kadallipura Puttaswamy Rakesh ◽  
Suhas Ramesh ◽  
Shivakumar ◽  
Dase Channe Gowda
Keyword(s):  
Antimicrobial Activity ◽  
Peptide Conjugates ◽  
Low Charge

Chemical Synthesis, Molecular Modeling, and Antimicrobial Activity of a Novel Bacteriocin, MMFII

2001 ◽  
Vol 289 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Mounir Ferchichi ◽  
Mohamed Fathallah ◽  
Pascal Mansuelle ◽  
Hervé Rochat ◽  
Jean-Marc Sabatier ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Modeling ◽  
Chemical Synthesis

scholarly journals Bioactivity and Structural Properties of Novel Synthetic Analogues of the Protozoan Toxin Climacostol

Toxins ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 42 ◽  
Author(s):  
Federico Buonanno ◽  
Elisabetta Catalani ◽  
Davide Cervia ◽  
Francesca Proietti Serafini ◽  
Simona Picchietti ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Cell Death ◽  
Chemical Synthesis ◽  
Aromatic Ring ◽  
Fungal Pathogens ◽  
Tumour Cells ◽  
The Other ◽  
Hydroxyl Group ◽  
Free Living ◽  
Methyl Group

Climacostol (5-[(2Z)-non-2-en-1-yl]benzene-1,3-diol) is a resorcinol produced by the protozoan Climacostomum virens for defence against predators. It exerts a potent antimicrobial activity against bacterial and fungal pathogens, inhibits the growth of several human and rodent tumour cells, and is now available by chemical synthesis. In this study, we chemically synthesized two novel analogues of climacostol, namely, 2-methyl-5 [(2Z)-non-2-en-1-yl]benzene-1,3-diol (AN1) and 5-[(2Z)-non-2-en-1-yl]benzene-1,2,3-triol (AN2), with the aim to increase the activity of the native toxin, evaluating their effects on prokaryotic and free-living protists and on mammalian tumour cells. The results demonstrated that the analogue bearing a methyl group (AN1) in the aromatic ring exhibited appreciably higher toxicity against pathogen microbes and protists than climacostol. On the other hand, the analogue bearing an additional hydroxyl group (AN2) in the aromatic ring revealed its ability to induce programmed cell death in protistan cells. Overall, the data collected demonstrate that the introduction of a methyl or a hydroxyl moiety to the aromatic ring of climacostol can effectively modulate its potency and its mechanism of action.

One-pot chemical synthesis of small ubiquitin-like modifier protein–peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates

2015 ◽  
Vol 10 (2) ◽  
pp. 269-292 ◽  
Author(s):  
Emmanuelle Boll ◽  
Hervé Drobecq ◽  
Nathalie Ollivier ◽  
Annick Blanpain ◽  
Laurent Raibaut ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
One Pot ◽  
Peptide Conjugates
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