Chemical Synthesis, Molecular Modeling, and Antimicrobial Activity of a Novel Bacteriocin, MMFII

2001 ◽  
Vol 289 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Mounir Ferchichi ◽  
Mohamed Fathallah ◽  
Pascal Mansuelle ◽  
Hervé Rochat ◽  
Jean-Marc Sabatier ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Modeling ◽  
Chemical Synthesis

Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, and evaluation of antimicrobial activity and mammalian cytotoxicity

Peptides ◽  
2019 ◽  
Vol 117 ◽  
pp. 170079 ◽  
Author(s):  
Natalia Ptaszyńska ◽  
Katarzyna Olkiewicz ◽  
Joanna Okońska ◽  
Katarzyna Gucwa ◽  
Anna Łęgowska ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Synthesis ◽  
Peptide Conjugates

scholarly journals Design, synthesis, antimicrobial activity and molecular modeling studies of novel benzofuroxan derivatives against Staphylococcus aureus

2009 ◽  
Vol 17 (8) ◽  
pp. 3028-3036 ◽  
Author(s):  
Salomão Dória Jorge ◽  
Andrea Masunari ◽  
Carlota Oliveira Rangel-Yagui ◽  
Kerly Fernanda Mesquita Pasqualoto ◽  
Leoberto Costa Tavares
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Molecular Modeling ◽  
Design Synthesis ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Deboronation of New Clarithromycin-Benzo[c][1,2]oxaborole Conjugates

2019 ◽  
Vol 17 (2) ◽  
pp. 99-104
Author(s):  
Gennady B. Lapa ◽  
Elena B. Isakova ◽  
Elena B. Mirchink ◽  
Maria N. Preobrazhenskaya
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Modeling ◽  
Carbonyl Group ◽  
Nucleophilic Attack ◽  
Bacterial Strains ◽  
Antimicrobial Spectrum ◽  
Intramolecular Complex ◽  
Active Fragments ◽  
Proven Method ◽  
Antibacterial Spectrum

<P>Background: The conjugates of antibiotics are new molecules that might show new antibacterial spectrum and overcome resistance of insusceptible bacterial strains. Modification of known antibiotics like Clarithromycin with active fragments is laborious and proven method to overcome resistance of such strains. Methods: The conjugates of Clarithromycin and Benzo[c][1,2]oxaboroles were synthesized using long linkers to extend antimicrobial spectrum of this antibiotic. Results and Discussion: Unexpected intramolecular deboronation of these bioconjugated was found to occur when the linker contained two or more CH2-groups. Molecular modeling was used to understand the source of instability and show a possibility of intramolecular complex of carbonyl group at C-9 in Clarithromycin core and hydroxy-borole moiety. This could facilitate nucleophilic attack of methanol used in reactions to destroy benzo[c][1,2]oxaboroles fragments and leave stable hydroxyl-aryl molecules. Conclusion: The loss of boron from benzo[c][1,2]oxoborole fragments leads to the significant decrease of antimicrobial activity of synthesized antibiotics.</P>

scholarly journals The phosphorylation site in double helical amylopectin as investigated by a combined approach using chemical synthesis, crystallography and molecular modeling

FEBS Letters ◽  
2003 ◽  
Vol 541 (1-3) ◽  
pp. 137-144 ◽  
Author(s):  
Søren Balling Engelsen ◽  
Anders Østergaard Madsen ◽  
Andreas Blennow ◽  
Mohammed Saddik Motawia ◽  
Birger Lindberg Møller ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Chemical Synthesis ◽  
Phosphorylation Site ◽  
Combined Approach

Synthesis, antimicrobial evaluation and molecular modeling of some novel phenothiazine derivatives

RSC Advances ◽  
2015 ◽  
Vol 5 (98) ◽  
pp. 80844-80852 ◽  
Author(s):  
Ahmed A. Fadda ◽  
Ahmed Fekri ◽  
Nesma M. Bayoumy
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Modeling ◽  
Theoretical Data ◽  
Phenothiazine Derivatives ◽  
High Antimicrobial Activity ◽  
Antimicrobial Evaluation

A novel series of phenothiazine derivatives were synthesized and examined for antimicrobial activity. Most of the newly synthesized compounds exhibited high antimicrobial activity and the results were proven using theoretical data.

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