A thermosensitive and photocrosslinkable composite polymer study for 3-D soft tissue scaffold printing

2021 ◽  
Author(s):  
Christopher Gerald Geisler
Keyword(s):  
Soft Tissue ◽  
Composite Polymer ◽  
Tissue Scaffold

Use of Bioabsorbable Tissue Reinforcement Reduces Incidence of Internal Hernia in Roux-en-Y Gastric Bypass Patients

2018 ◽  
Vol 84 (11) ◽  
pp. 1756-1761
Author(s):  
Michael W. Love ◽  
Roosbeh Mansour ◽  
Allyson L. Hale ◽  
Eric S. Bour ◽  
Ihab Shenouda ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Soft Tissue ◽  
Internal Hernia ◽  
Tissue Scaffold ◽  
Internal Hernias ◽  
Early Evidence ◽  
Hernia Formation ◽  
Tissue Matrix ◽  
Tissue Defects ◽  
Prospective Database

Internal hernias are one of the most devastating late, postsurgical complications associated with laparoscopic Roux-en-Y gastric bypass (LRYGB). The objective of this study was to determine whether placement of a bioabsorbable tissue matrix in soft tissue defects after gastric bypass resulted in a lower incidence of internal hernia development. Prospective database was used to identify all patients who underwent LRYGB between January 2002 and January 2016. These patients were then retrospectively reviewed to determine the development of internal hernia. Before 2009, the retro-Roux defect was left open during the primary operation and the defect at the jejunojejunostomy was closed with sutures or staples. Beginning in 2009, all soft tissue internal defects were reinforced with an 8 cm 3 8-cm piece of bioabsorbable matrix. The incidence of subsequent internal hernia development was compared between these two groups: no bioabsorbable matrix versus use of a bioabsorbable matrix. A total of 2771 patients underwent LRYGB during our study period. From these, 1215 procedures were performed without tissue reinforcement and 1556 were performed using a bioabsorbable matrix. During the study period, 274 patients developed an internal hernia. Patients who did not have tissue reinforcement at closure had a significantly higher internal hernia rate [225/1215 (18.5%) vs 49/1556 (3.1%), P < 0.005]. This study demonstrates a statistically significant reduction in internal hernia formation after LRYGB with the addition of a bioabsorbable tissue matrix. Although prospective studies are needed, early evidence suggests that reinforcement with a bioabsorbable tissue scaffold is an effective method for minimizing internal hernias after LRYGB.

scholarly journals In vitro and in vivo evaluation of orthopedic interface repair using a tissue scaffold with a continuous hard tissue-soft tissue transition

2013 ◽  
Vol 8 (1) ◽  
pp. 18 ◽  
Author(s):  
Darryl A Dickerson ◽  
Tarik N Misk ◽  
David C Van Sickle ◽  
Gert J Breur ◽  
Eric A Nauman
Keyword(s):  
Soft Tissue ◽  
Hard Tissue ◽  
In Vivo Evaluation ◽  
Tissue Scaffold

scholarly journals Nano Iron Oxide-PCL Composite as an Improved Soft Tissue Scaffold

Processes ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1559
Author(s):  
Vahid Rezaei ◽  
Esmaeil Mirzaei ◽  
Seyedeh-Masoumeh Taghizadeh ◽  
Aydin Berenjian ◽  
Alireza Ebrahiminezhad
Keyword(s):  
Iron Oxide ◽  
Soft Tissue ◽  
Fe3o4 Nanoparticles ◽  
Cell Attachment ◽  
Growth Promotion ◽  
Precipitation Reaction ◽  
Promoting Effect ◽  
Electrospinning Technique ◽  
Tissue Scaffold ◽  
Nanocomposite Scaffolds

Iron oxide nanoparticles were employed to fabricate a soft tissue scaffold with enhanced physicochemical and biological characteristics. Growth promotion effect of L-lysine coated magnetite (Lys@Fe3O4) nanoparticles on the liver cell lines was proved previously. So, in the current experiment these nanoparticles were employed to fabricate a soft tissue scaffold with growth promoting effect on the liver cells. Lys@Fe3O4 nanoparticles were synthesized via co-precipitation reaction. Resulted particles were ~7 nm in diameter and various concentrations (3, 5, and 10 wt%) of these nanoparticles were used to fabricate nanocomposite PCL fibers. Electrospinning technique was employed and physicochemical characteristics of the resulted nanofibers were evaluated. Electron micrographs and EDX-mapping analysis showed that nanoparticles were well dispersed in the PCL fibers and no bead structure were formed. As expected, incorporation of Lys@Fe3O4 to the PCL nanofibers resulted in a reduction in hydrophobicity of the scaffold. Nanocomposite scaffolds were shown increased tensile strength with increasing concentration of employed nanoparticles. In contrast to PCL scaffold, nearly 150% increase in the cell viability was observed after 3-days exposure to the nanocomposite scaffolds. This study indicates that incorporation of magnetite nanoparticles in the PCL fibers make them more prone to cell attachment. However, incorporated nanoparticles can provide the attached cells with valuable iron element and consequently promote the cells growth rate. Based on the results, magnetite enriched PCL nanofibers could be introduced as a scaffold to enhance the biological performance for liver tissue engineering purposes.

scholarly journals Hybrid Three‐Dimensional–Printed Ear Tissue Scaffold With Autologous Cartilage Mitigates Soft Tissue Complications

2020 ◽  
Author(s):  
Brian Chang ◽  
Ashley Cornett ◽  
Zahra Nourmohammadi ◽  
Jadan Law ◽  
Blaine Weld ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Three Dimensional ◽  
Tissue Scaffold

scholarly journals Gelatin-Modified Polyurethanes for Soft Tissue Scaffold

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Justyna Kucińska-Lipka ◽  
Iga Gubańska ◽  
Helena Janik
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Positive Impact ◽  
Engineering Application ◽  
Synthetic Polymers ◽  
Hexamethylene Diisocyanate ◽  
Tissue Engineering Application ◽  
Natural Polymers ◽  
Tissue Scaffold ◽  
Pu Foams

Recently, in the field of biomaterials for soft tissue scaffolds, the interest of their modification with natural polymersis growing. Synthetic polymers are often tough, and many of them do not possess fine biocompatibility. On the other hand, natural polymers are biocompatible but weak when used alone. The combination of natural and synthetic polymers gives the suitable properties for tissue engineering requirements. In our study, we modified gelatin synthetic polyurethanes prepared from polyester poly(ethylene-butylene adipate) (PEBA), aliphatic 1,6-hexamethylene diisocyanate (HDI), and two different chain extenders 1,4-butanediol (BDO) or 1-ethoxy-2-(2-hydroxyethoxy)ethanol (EHEE). From a chemical point of view, we replaced expensive components for building PU, such as 2,6-diisocyanato methyl caproate (LDI) and 1,4-diisocyanatobutane (BDI), with cost-effective HDI. The gelatin was added in situ (in the first step of synthesis) to polyurethane to increase biocompatibility and biodegradability of the obtained material. It appeared that the obtained gelatin-modified PU foams, in which chain extender was BDO, had enhanced interactions with media and their hydrolytic degradation profile was also improved for tissue engineering application. Furthermore, the gelatin introduction had positive impact on gelatin-modified PU foams by increasing their hemocompatibility.

Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

2003 ◽  
Vol 13 (4) ◽  
pp. 654-656 ◽  
Author(s):  
Karl D. Pavey ◽  
Stuart L. James ◽  
S. Elizabeth James ◽  
Lyuba I. Mikhalovska ◽  
Paul Tomlins ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Real Time ◽  
Real Time Monitoring ◽  
Tissue Scaffold ◽  
Scaffold Materials

Acellular Adipose Tissue Scaffold for Soft Tissue Reconstruction

2011 ◽  
Vol 128 ◽  
pp. 83-84 ◽  
Author(s):  
Iwen Wu ◽  
Zayna Nahas ◽  
Gedge Rosson ◽  
Jennifer Elisseeff
Keyword(s):  
Adipose Tissue ◽  
Soft Tissue ◽  
Soft Tissue Reconstruction ◽  
Tissue Scaffold ◽  
Tissue Reconstruction

Methods for Achieving Soft Tissue Scaffold Sterility

2009 ◽  
Vol 4 ◽  
pp. 59-69 ◽  
Author(s):  
Alex Baume ◽  
Nick Coleman ◽  
Philip Boughton
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Medical Devices ◽  
Tissue Engineering Scaffold ◽  
Test Method ◽  
Mechanical Agitation ◽  
Packaging System ◽  
Tissue Scaffold ◽  
And Performance

The manufacturing process for in vitro tissue culture products and medical devices relies on a validated sterilization route for ensuring product sterility, safety and performance. Two key aspects that contribute toward final sterilization validation are (1) the reliable estimation of product bioburden and (2) the development of a proficient sterile packaging system. Bioabsorbable composite systems and architecture of tissue scaffolds can lead to numerous challenges for bioburden testing and packaging design. This study is concerned with the development of bioburden assessment methods and packaging systems for Variotis™; a soft tissue engineering scaffold. A bioburden test method relying on mechanical agitation was established. Bioburden assessment was achieved by recovering Geobacillus stearothermophilus spore inoculant for analysis. A packaging system was developed which provides adequate protection for Variotis™ scaffolds while meeting other user/sterilization requirements for research grade product. The guidelines and design approaches included in this study are generally applicable to other tissue engineering scaffold and medical devices.

Regulation of the Morphological and Physical Properties of a Soft Tissue Scaffold by Manipulating DD and DS of O-Carboxymethyl Chitin

2020 ◽  
Vol 3 (9) ◽  
pp. 6187-6195
Author(s):  
Liqing Zhao ◽  
Wenjing Deng ◽  
Muhammad Shahid Riaz Rajoka ◽  
Dejiao Cai ◽  
Tao Xing ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Physical Properties ◽  
Tissue Scaffold
Sign in / Sign up

Export Citation Format

Share Document