scholarly journals Disappearance of cerebral cortical atrophy following replacement therapy with vitamin B12 in an infant

2015 ◽  
Vol 41 (1) ◽  
pp. 152
Author(s):  
Ebru Yılmaz Keskin
Keyword(s):  
Vitamin B12 ◽  
Replacement Therapy ◽  
Cortical Atrophy ◽  
Cerebral Cortical Atrophy

Regional Cerebral Cortical Atrophy is Related to Urinary Tract Symptoms in Parkinson's Disease

2021 ◽  
Vol 31 (2) ◽  
pp. 363-371
Author(s):  
Haewon Roh ◽  
June Kang ◽  
Soon‐Young Hwang ◽  
Seong‐Beom Koh ◽  
Jong Hyun Kim
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Urinary Tract ◽  
Cortical Atrophy ◽  
Urinary Tract Symptoms ◽  
Cerebral Cortical Atrophy

Dementia and subnormal levels of vitamin B12: Effects of replacement therapy on dementia

1996 ◽  
Vol 243 (7) ◽  
pp. 522-529 ◽  
Author(s):  
Saskia Teunisse ◽  
Anna E. Bollen ◽  
Willem A. van Gool ◽  
Gerard J.M. Walstra
Keyword(s):  
Vitamin B12 ◽  
Replacement Therapy

scholarly journals Prevalence of individual brain and eye defects potentially related to Zika virus in pregnancy in 22 U.S. states and territories, January 2016 - June 2017

2022 ◽  
Author(s):  
Augustina Delaney ◽  
Samantha M. Olson ◽  
Nicole M. Roth ◽  
Janet D. Cragan ◽  
Shana Godfred-Cato ◽  
...  
Keyword(s):  
Birth Defects ◽  
Zika Virus ◽  
Cortical Atrophy ◽  
Zikv Infection ◽  
Live Births ◽  
Prevalence Estimates ◽  
Surveillance Programs ◽  
Prevalence Ratios ◽  
Cerebral Cortical Atrophy ◽  
In Pregnancy

Abstract During the Centers for Disease Control and Prevention’s Zika Virus Response, birth defects surveillance programs adapted to monitor birth defects potentially related to Zika virus (ZIKV) infection during pregnancy. Pregnancy outcomes occurring during January 2016-June 2017 in 22 U.S. states and territories were used to estimate the prevalence of those brain and eye defects potentially related to ZIKV. Jurisdictions were divided into three groups: areas with widespread ZIKV transmission, areas with limited local ZIKV transmission, and areas without local ZIKV transmission. Prevalence estimates for selected brain and eye defects and microcephaly per 10,000 live births were estimated. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were estimated using Poisson regression for areas with widespread and limited ZIKV transmission compared to areas without local ZIKV transmission. Defects with significantly higher prevalence in areas of widespread transmission were pooled, and PRs were calculated by quarter, comparing subsequent quarters to the first quarter (January – March 2016). Nine defects had significantly higher prevalence in areas of widespread transmission. The highest PRs were seen in intracranial calcifications (PR=12.6, 95% CI [7.4, 21.3]), chorioretinal abnormalities (12.5 [7.1, 22.3]), brainstem abnormalities (9.3, [4.7, 18.4]), and cerebral/cortical atrophy (6.7, [4.2, 10.8]). The PR of the nine pooled defects was significantly higher in three quarters in areas with widespread transmission. The largest difference in prevalence was observed for defects consistently reported in infants with congenital ZIKV infection. Birth defects surveillance programs could consider monitoring a subset of birth defects potentially related to ZIKV in pregnancy.

scholarly journals A Preventable Cause of Hypotonia in Infants: Case Report of Two Infants with Vitamin B12 Deficiency

2021 ◽  
Vol 3 (2) ◽  
pp. 48-51
Author(s):  
Akhrif M ◽  
Saghir S ◽  
Kmari M ◽  
Ourrai A ◽  
Hassani A ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Clinical Signs ◽  
Vitamin B12 Deficiency ◽  
Vegan Diet ◽  
Cortical Atrophy ◽  
Neurological Damage ◽  
Delay In Diagnosis ◽  
Raising Awareness ◽  
B12 Deficiency ◽  
High Level

Introduction: Innate deficits in the metabolism or transport of vitamin B12 are exceptional. The main cause of vitamin B12 deficiency in infants is secondary to maternal deficiency. Maternal deficiency can have a vegan diet, low socio-economic level (developing countries) and a high level of development with a poor diet) or digestive pathologies responsible for a lack of absorption. The clinical signs are not very specific (developmental delay, pallor, hypotonia, vomiting and diarrhoea), which explains the frequent delay in diagnosis. The pathophysiology of the neurological damage, which is still uncertain, is thought to be secondary to a defect in myelination with altered nerve conduction and cortical atrophy. The aim of this work is to underline the importance of raising awareness of vitamin B12 deficiency in order to avoid its profound neurological repercussions, especially as substitution treatment allows an improvement or a reversibility of the neurological damage and raises the question of the possibility of screening new-borns. Materials and Methods: We report the case of two infants aged 6 months and 10 months with hypotonia and psychomotor regression from an early age, whose biological examination revealed pancytopenia with a collapsed vitamin B12 level in both infants and both mothers.

Cerebral Cortical Atrophy in Pediatric Patients With End-Stage Renal Disease

1983 ◽  
Vol 2 (6) ◽  
pp. 645-650 ◽  
Author(s):  
H. William Schnaper ◽  
Barbara R. Cole ◽  
Fred J. Hodges ◽  
Alan M. Robson
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Pediatric Patients ◽  
Cortical Atrophy ◽  
Stage Renal Disease ◽  
End Stage ◽  
Cerebral Cortical Atrophy

scholarly journals Hipotiroidismo primario, déficit de vitamina B12 y tiroiditis subaguda sobreagregada: informe de caso

2017 ◽  
Vol 2 (4) ◽  
pp. 51-54
Author(s):  
Carlos Alfonso Builes Barrera ◽  
María Gabriela García Orjuela
Keyword(s):  
Vitamin B12 ◽  
Replacement Therapy ◽  
Thyroid Disease ◽  
Vitamin B12 Deficiency ◽  
Primary Hypothyroidism ◽  
Subacute Thyroiditis ◽  
Normal Range ◽  
Hormonal Replacement ◽  
B12 Deficiency ◽  
Over Time

El hipotiroidismo primario es la patología tiroidea más frecuente. El manejo estándar de esta enfermedad es con levotiroxina, cuya absorción puede verse afectada por distintas condiciones médicas, medicamentos e incluso la dieta del paciente. Los requerimientos de levotiroxina podrían variar debido a factores sobre agregados como la tiroiditis subaguda, la deficiencia de vitamina B12 y el uso de medicamentos, elementos que afectan el control del hipotiroidismo. Se presenta el caso de una paciente con hipotiroidismo primario con necesidad de ajuste en la dosis de levotiroxina a través del tiempo debido a comorbilidades agregadas. Se presentan claves para la evaluación del paciente con dificultad para lograr una TSH dentro del rango normal.Abstract Hypothyroidism is the most common thyroid disease. This disease is managed with hormonal replacement therapy using levothyroxine, whose absorption can be affected by various medical conditions, drugs and even patient´s diet. Levothyroxine requirements could vary according to co-morbidities such as subacute thyroiditis, vitamin B12 deficiency and the use of drugs, factors that can affect the control of hypothyroidism. The case of a patient with primary hypothyroidism who required dose adjustments of levothyroxine over time due to added co-morbidities is presented. Clues are given for evaluation of the patient with difficulty in achieving maintenance of TSH within the normal range. 

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