scholarly journals Per oral vitamin B12 replacement therapy after gastrectomy and its optimal dose; retrospective study

2018 ◽  
Vol 1 (4) ◽  
Keyword(s):  
Retrospective Study ◽  
Vitamin B12 ◽  
Replacement Therapy ◽  
Optimal Dose ◽  
Oral Vitamin ◽  
Per Oral

Per oral vitamin B12 replacement therapy after gastrectomy and its optimal dose (retrospective study) and our protocol of a prospective clinical trial.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 338-338
Author(s):  
Yasushi Rino ◽  
Toru Aoyama ◽  
Norio Yukawa ◽  
Haruhiko Cho ◽  
Takashi Oshima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Trial ◽  
Vitamin B12 ◽  
Replacement Therapy ◽  
Total Gastrectomy ◽  
Initial Treatment ◽  
Vitamin B12 Deficiency ◽  
Oral Vitamin ◽  
B12 Deficiency ◽  
Per Oral

338 Background: Postgastrectomy vitamin B12 deficiency is common metabolic sequel and worsens the quality of life of gastric cancer survivors. Recently, oral vitamin B12 replacement is reported. Therefore, we investigated retrospectively the efficacy of oral vitamin B12 replacement for gastric cancer patients with vitamin B12 deficiency after total gastrectomy. Methods: We reviewed 73 patients with gastric cancer who underwent total gastrectomy and were treated vitamin B12 replacement. Patients were consisted of 56 males and 17 females and median age was 70 y/o. We investigated initial treatment of vitamin B12 replacement and improvement of vitamin B12 deficiency. Results: Initial treatment of vitamin B12 replacements were intramuscular injection for 42 patients, per oral replacement for 28 patients and intravenous injection for 3 patients. Finally, all patients were treated with per oral replacement and the serum vitamin B12 levels became within normal range. Final vitamin B12 doses of replacement therapy were 500 µg of 20 out of 73 pts, respectively. Conclusions: Vitamin B12 replacement therapy should be necessary and continued. According to our results, one vitamin B12 tablet a day is enough. The vitamin B12 deficiency symptoms could be prevented. 500 micrograms vitamin B12 replacement orally is maybe effective and necessary. Our prospective clinical protocol (UMIN000030727): In this study, an oral vitamin B12 preparation (1500 μg/day, administered daily) was set as the control treatment, and a specific clinical trial was started to determine whether 500 μg/day daily administration would be sufficient for replacement therapy. Clinical trial information: UMIN000030727.

Switching to Oral Vitamin B12 Replacement

2006 ◽  
Vol 39 (18) ◽  
pp. 30
Author(s):  
JON O. EBBERT ◽  
ERIC G. TANGALOS
Keyword(s):  
Vitamin B12 ◽  
Oral Vitamin

scholarly journals Optimal dose of renal replacement therapy in acute kidney injury: a meta-analysis

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 1) ◽  
pp. P268
Author(s):  
RJ Van Wert ◽  
DC Scales ◽  
JO Friedrich ◽  
R Wald ◽  
NK Adhikari
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Optimal Dose

scholarly journals Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders

2018 ◽  
Vol 7 (10) ◽  
pp. 304 ◽  
Author(s):  
Emmanuel Andrès ◽  
Abrar-Ahmad Zulfiqar ◽  
Khalid Serraj ◽  
Thomas Vogel ◽  
Georges Kaltenbach
Keyword(s):  
Vitamin B12 ◽  
Prospective Studies ◽  
Clinical Manifestations ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Cochrane Library ◽  
Clinical Approach ◽  
Oral Vitamin ◽  
Hand Search ◽  
B12 Deficiency

The objective of this review is to provide an update on the effectiveness of oral and nasal vitamin B12 (cobalamin) treatment in gastrointestinal (GI) disorders. Relevant articles were identified by PubMed and Google Scholar systematic search, from January 2010 and June 2018, and through hand search of relevant reference articles. Additional studies were obtained from references of identified studies, the Cochrane Library and the ISI Web of Knowledge. Data gleaned from reference textbooks and international meetings were also used, as was information gleaned from commercial sites on the web and data from CARE B12 research group. For oral vitamin B12 treatment, 4 randomized controlled trials (vs. intramuscular), 4 narrative and 4 systematic reviews, and 13 prospective studies fulfilled our inclusion criteria. These studies concerned patients with vitamin B12 deficiency related to: food-cobalamin malabsorption (n = 6), Biermer’s disease (n = 3), veganism or vegetarianism (n = 1), total gastrectomy after Roux-en-Y gastric bypass (n = 2) and Crohn’s disease (n = 1). Four prospective studies include patients with vitamin B12 deficiency related to the aforementioned etiologies, except veganism or vegetarianism. The systematic present review documents that oral vitamin B12 replacement, at a daily dose of 1000 μg (1 mg), was adequate to normalize serum vitamin B12 levels and cure main clinical manifestations related to vitamin B12 deficiency, in GI disorders, and thus, with safety profile. For nasal vitamin B12 treatment, only one preliminary study was available. We conclude that oral vitamin B12 is an effective alternative to intramuscular vitamin B12 (except in patients presenting with severe neurological manifestations). Oral vitamin B12 treatment avoids the discomfort, contraindication (in patients with anticoagulation), and cost of monthly injections.

Oral vitamin B12 therapy: a cautionary note

Blood ◽  
2004 ◽  
Vol 103 (7) ◽  
pp. 2863-2863 ◽  
Author(s):  
Lawrence R. Solomon
Keyword(s):  
Vitamin B12 ◽  
Cautionary Note ◽  
Oral Vitamin

Oral Vitamin B12 in the Treatment of Macrocytic Anemias

1955 ◽  
Vol 48 (3) ◽  
pp. 261-269 ◽  
Author(s):  
WALTER C. UNGLAUB ◽  
GRACE A. GOLDSMITH
Keyword(s):  
Vitamin B12 ◽  
Oral Vitamin
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