scholarly journals Changes in the motivational component of sexual function in the offspring of rats after prenatal exposure to cholinotropic drugs

2020 ◽  
Vol 18 (1) ◽  
pp. 29-36
Author(s):  
Elena V. Stashina ◽  
Artur O. Zelener ◽  
Alekber A. Bairamov ◽  
Petr D. Shabanov
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Activity ◽  
Prenatal Exposure ◽  
Sexual Experience ◽  
Male Rats ◽  
Dopaminergic Systems ◽  
The Brain ◽  
Sexually Mature

Prenatal exposure to N-cholinoblocker gangleron and in lesser degree to M-cholinoblocker metamisil leads to significant violations of the motivational component of sexual function in sexually mature offspring of males, expressed in low values of primary sexual activity, and increased latency of the approach and sexual dysfunction after the acquisition of sexual experience. Among the causes of sexual dysfunction in the offspring, it can be noted a change in the hormonal background in male rats, in the form of a significant decrease in the level of the main androgen testosterone, as well as damage in the dopaminergic systems of the brain, manifested by a decrease in dopamine levels.

scholarly journals FEATURES OF ASSESSING THE SEXUAL BEHAVIOR OF MALE RATS IN THE STUDY OF THE EFFECTS OF COMPOUNDS THAT HAVE A STIMULATING EFFECT ON SEXUAL FUNCTION

2020 ◽  
Author(s):  
Svetlana N. Subbotina ◽  
Anastasiya A. Kryazhevskikh ◽  
Aleksey A. Kryazhevskikh ◽  
Mikhail A. Yudin ◽  
Elizaveta I. Eletskaya
Keyword(s):  
Sexual Behavior ◽  
Sexual Function ◽  
Sexual Activity ◽  
Mechanism Of Action ◽  
Experimental Models ◽  
Central Mechanism ◽  
Male Rats ◽  
Test Duration ◽  
Pharmacological Agents

The paper presents a comparative analysis of information content of methods for assessing the copulatory behavior of male rats with the introduction of compounds that have a stimulating effect on the sexual activity of animals. The social significance of the problem of sexual dysfunctions determines the relevance of the development of various experimental models of sexual behavior that allow assessing the effectiveness and safety of new drug. The probability of detecting the activating effect of pharmacological agents on sexual activity directly depends on the correct choice of the experimental model. The drugs of the central mechanism of action galantamine hydrobromide (1mg/kg) and loxidan (1,7mg/kg), were used as pharmacological agents; drugs of peripheral action were yohimbine hydrochloride (2,6mg/kg) and vardenafil hydrochloride (1,7mg/kg). It has been shown that the determination of the stimulating effects of compounds of the central mechanism of action is possible using methods with different testing duration (from 15 to 180min). Thus, the introduction of galantamine enhances the sexual activity of males in terms of the copulation rate, the number of perfect ejaculations and the duration of the post-ejaculatory refractory period, loxidan in terms of the total number of intromissions and relative rest time in tests of limited duration. In the test showing the completed sexual cycle of males, the stimulating effects of galantamine are shown in terms of the number of completed copulatory series and the number of completed ejaculations. To assess the activating effects of compounds of the peripheral mechanism of action, the expediency of using experimental models with a test duration of 30 minutes or more was shown. The most informative test is the test of paired interaction between a male and a female until the male reaches the state of sexual exhaustion. A method with high information content is presented, which provides a high probability of detecting the activating effect of compounds on the sexual function of male rats. Determination of the stimulating effects of compounds of the central mechanism of action is possible using methods with different test duration

scholarly journals The Impact of the COVID-19 Pandemic on Depression and Sexual Function: Are Pregnant Women Affected More Adversely?

2021 ◽  
Vol 43 (10) ◽  
pp. 765-774
Author(s):  
Ramazan Denizli ◽  
Önder Sakin ◽  
Kazibe Koyuncu ◽  
Nayif Çiçekli ◽  
Nihat Farisoğulları ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Pregnant Women ◽  
Low Income ◽  
Sexual Experience ◽  
Economic Status ◽  
Depression Score ◽  
Income Loss ◽  
Increased Risk ◽  
The Impact

Abstract Objective To investigate depression and sexual function among pregnant and non-pregnant women throughout the COVID-19 pandemic. Methods A total of 188 women, 96 pregnant and 92 non-pregnant were included. The Beck Depression Inventory (BDI) and the Arizona Sexual Experience Scale (ASEX) were applied to the participants after obtaining sociodemographic data. Results The depression scores of pregnant and non-pregnant women were similar (p = 0.846). We found that the depression scores were significantly higher among the group of participants who have lower economic status (p = 0.046). Moreover, the depression score was significantly higher among women who lost their income during the pandemic (p = 0.027). The score on the ASEX was significantly higher, and sexual dysfunction was more prevalent among women who have lower levels of schooling and income (p < 0.05). Likewise, the ASEX scores were significantly higher (p = 0.019) among the group who experienced greater income loss throughout the pandemic. Upon comparing the pregnant and non-pregnant groups, we detected that sexual dysfunction had a significantly higher rate among pregnant women (p < 0.001). Conclusion In times of global crisis, such as the current pandemic, low-income families have an increased risk of experiencing depression and sexual dysfunction. When we compared pregnant women with non-pregnant women, depression scores were similar, but pregnant women were at a 6.2 times higher risk of developing sexual dysfunction.

scholarly journals The evolution of the female sexual response concept: Treatment implications

2013 ◽  
Vol 141 (3-4) ◽  
pp. 268-274 ◽  
Author(s):  
Aleksandar Damjanovic ◽  
Dragana Duisin ◽  
Jasmina Barisic
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Experience ◽  
Sexual Response ◽  
Sexual Disorders ◽  
Critical Question ◽  
Circular Model ◽  
Sexual Distress ◽  
Female Sexual Response ◽  
The Relationship

Sexual dysfunctions have been the most prevalent group of sexual disorders and include a large number of populations of both sexes. The research of sexual behavior and treatment of women with sexual distress arises many questions related to differences in sexual response of men and women. The conceptualization of this response in modern sexology has changed over time. The objective of our paper was to present the changes and evolution of the female?s sexual response concept in a summarized and integrated way, to analyze the expanded and revised definitions of the female sexual response as well as implications and recommendations of new approaches to diagnostics and treatment according to the established changes. The lack of adequate empirical basis of the female sexual response model is a critical question in the literature dealing with this issue. Some articles report that linear models demonstrate more correctly and precisely the sexual response of women with normal sexual functions in relation to women with sexual dysfunction. Modification of this model later resulted in a circular model which more adequately presented the sexual response of women with sexual function disorder than of women with normal sexual function. The nonlinear model of female sexual response constructed by Basson incorporates the value of emotional intimacy, sexual stimulus and satisfaction with the relationship. Female functioning is significantly affected by multiple psychosocial factors such as satisfaction with the relationship, self-image, earlier negative sexual experience, etc. Newly revised, expanded definitions of female sexual dysfunction try to contribute to new knowledge about a highly contextual nature of woman?s sexuality so as to enhance clinical treatment of dysfunctions. The definitions emphasize the evaluation of the context of women?s problematic sexual experiences.

Sexual activity and function in male cancer patients receiving targeted an immune therapies.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e21594-e21594
Author(s):  
Katy K. Tsai ◽  
Puneet Kamal ◽  
Joris Ramstein ◽  
Alain Patrick Algazi ◽  
Adil Daud ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Activity ◽  
Cancer Patients ◽  
Cancer Diagnosis ◽  
Comprehensive Cancer Center ◽  
Cancer Center ◽  
Care Providers ◽  
Long Term Treatment ◽  
And Function

e21594 Background: Survivorship concerns–including sexual function–move increasingly to the foreground in cancer patient care as systemic therapies improve response and survival. Patients are often committed to long-term treatment with tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors (ICI) despite poor characterization of their effects on sexual function. We sought to assess sexual activity and function in patients receiving TKI or ICI. Methods: A cohort of men receiving TKI/ICI at the UCSF Helen Diller Family Comprehensive Cancer Center were retrospectively identified. Eligible men were on ongoing TKI/ICI therapy. Detailed questionnaires addressing cancer history, treatment history, and sexual activity/function while receiving therapy were completed. Results: Between January 2013 to September 2016, 51 men completed questionnaires. Mean age was 46 years (SD 12, range 21-72). Most (61%) were CML patients, with 12% RCC, 10% GIST, 6% melanoma, and NET, oligodendroglioma, and HCC comprising remaining histologies. 96% were treated with TKI, and 4% with ICI (pembrolizumab). 32% identified as being married or in a domestic partnership, and 18% identified as single. Only 14% reported no attempted sexual activity. Sexual desire was described as low or very low to none in 29%, average in 39%, and high or very high in 29%. Since cancer diagnosis, 21 (41%) of patients noted a reduced amount of semen upon ejaculation, and all but 5 of those patients noted this as at least somewhat bothersome. 35% of patients reported feeling at least somewhat distressed from sexual experiences since cancer diagnosis, including concern that their time to ejaculation may leave their partners feeling unfulfilled (45%), decreased sensation of orgasm (35%), difficulty maintaining erection until completion of intercourse (23%), and pain/discomfort upon ejaculation (12%). Conclusions: The majority of men on TKI or ICI remain sexually active, with a significant portion reporting sexual dysfunction. These findings highlight the need for oncology care providers to proactively manage sexual dysfunction to improve quality of life for cancer patients. Retrospective and prospective studies are ongoing to further characterize this cohort.

scholarly journals Sexual Experience Induces the Expression of Gastrin-Releasing Peptide and Oxytocin Receptors in the Spinal Ejaculation Generator in Rats

2021 ◽  
Vol 22 (19) ◽  
pp. 10362
Author(s):  
Takumi Oti ◽  
Ryota Ueda ◽  
Ryoko Kumagai ◽  
Junta Nagafuchi ◽  
Takashi Ito ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Sexual Activity ◽  
Neural Circuits ◽  
Sexual Experience ◽  
Lumbar Spinal Cord ◽  
Gastrin Releasing Peptide ◽  
Oxytocin Receptors ◽  
Male Sexual Function ◽  
Lumbar Spinal ◽  
The Brain

Male sexual function in mammals is controlled by the brain neural circuits and the spinal cord centers located in the lamina X of the lumbar spinal cord (L3–L4). Recently, we reported that hypothalamic oxytocin neurons project to the lumbar spinal cord to activate the neurons located in the dorsal lamina X of the lumbar spinal cord (dXL) via oxytocin receptors, thereby facilitating male sexual activity. Sexual experiences can influence male sexual activity in rats. However, how this experience affects the brain–spinal cord neural circuits underlying male sexual activity remains unknown. Focusing on dXL neurons that are innervated by hypothalamic oxytocinergic neurons controlling male sexual function, we examined whether sexual experience affects such neural circuits. We found that >50% of dXL neurons were activated in the first ejaculation group and ~30% in the control and intromission groups in sexually naïve males. In contrast, in sexually experienced males, ~50% of dXL neurons were activated in both the intromission and ejaculation groups, compared to ~30% in the control group. Furthermore, sexual experience induced expressions of gastrin-releasing peptide and oxytocin receptors in the lumbar spinal cord. This is the first demonstration of the effects of sexual experience on molecular expressions in the neural circuits controlling male sexual activity in the spinal cord.

scholarly journals COPD burden on sexual well-being

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
M. Zysman ◽  
J. Rubenstein ◽  
F. Le Guillou ◽  
R. M. H. Colson ◽  
C. Pochulu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Dysfunction ◽  
Sexual Activity ◽  
Sexual Experience ◽  
Well Being ◽  
Sexual Life ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Impact

Abstract Background Sexual function is often affected in patients suffering from chronic diseases especially chronic obstructive pulmonary disease (COPD). However, the effect of COPD on sexual satisfaction is underappreciated in clinical practice. The aim of this study is to evaluate the impact of COPD on patient’s sexuality and the explanatory variables of sexual dissatisfaction. Methods Questionnaires were emailed to participants and they submitted their responses on the Santé Respiratoire France website. Data about sexual well-being (Arizona Sexual Experience Scale, ASEX), Quality of life (VQ11), anxiety, depression (Hospitalized anxiety and depression, HAD) and self-declared COPD grade were collected. Results Seven hundred and fifty one subjects were included and were characterized as follows: women—51%, mean age—61 years, in a couple—62% and 70%—retired. Every grade of COPD was represented. Out of 751 participants, 301 participants (40%) had no sexual activity and 450 (60%) had sexual activity. From the 450 participants, 60% needed to change their sexual life because of their disease (rhythm, frequency and position). Subjects often used medications to improve sexual performance (43% used short-acting bronchodilator and 13% -specific erectile dysfunction drugs). ASEX questionnaire confirmed patients’ dissatisfaction (diminution of sexual appetite for 68% and sexual desire for 60%) because of breathlessness and fatigue. Eighty one percent of the responders had an altered quality of life (VQ11 mean score 35) and frequent suspected anxiety or depression (HAD mean score 10.8). Ninety percent declared that sexual dysfunction had never been discussed by their doctors, while 36% of patients would have preferred to undergo a specialized consultation. Conclusion Sexual dysfunction is frequent among COPD patients and leads to an altered well-being, however being a cultural taboo, it remains frequently neglected. Sexual guidance should be a part of patient’s consultations improve quality of sexual life.

Costs of pleasure and the benefits of pain: self-perceived genital sensation, anatomy and sexual dysfunction

Sexual Health ◽  
2016 ◽  
Vol 13 (1) ◽  
pp. 63
Author(s):  
Nina Callens ◽  
Guy Bronselaer ◽  
Petra De Sutter ◽  
Griet De Cuypere ◽  
Guy T'Sjoen ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Experience ◽  
Sexual Pleasure ◽  
P Value ◽  
Self Assessment ◽  
Web Based ◽  
Sexual Distress ◽  
Distress Scale ◽  
Genital Sensation

Background Research has highlighted the complex association between female sexual dysfunction (FSD) and distress regarding sexual activity, with decreased physical pleasure being an important mediator. The current study aims to elucidate the association between pleasurable and painful genital sensitivity and FSD, and to further investigate whether FSD may be distressing because it prevents the experience of sexual pleasure, induces pain or both. Methods: Sexually active women (n = 256; median, 22 years; range, 18–49 years) completed web-based questionnaires, including the Self-Assessment of Genital Anatomy and Sexual Function, the Female Sexual Function Index and the Female Sexual Distress Scale. Results: Women reported their clitoris to be more sensitive than their vagina in terms of having more pleasurable responses (P < 0.001), but not more painful responses (P = 0.49). In women with FSD (n = 36), impaired self-perceived genital sensation was found: they reported significantly less sexual pleasure and orgasm intensity, and more orgasm effort and discomfort within the clitoral and vaginal area than women without FSD (n = 220) (P-value < 0.05). The odds of having FSD were significantly greater in women with perceived increased discomfort in the vaginal area during stimulation (odds ratio = 5.59, P = 0.009, 95% confidence interval: 1.53–20.39), but not in the clitoral area. Conclusions: The data provide evidence of the relevance of self-perceived genital sensitivity to sexual pleasure and overall sexual experience. Enhancing the pleasurableness of genital sensations, especially during partnered sex, could decrease the likelihood of experiencing pain and concomitant FSD.

scholarly journals AB0959 FREQUENCY OF SEXUAL DYSFUNCTION IN WOMEN WITH FIBROMYALGIA

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1776.1-1777
Author(s):  
O. Teplyakova ◽  
A. Popov
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Activity ◽  
Body Mass ◽  
Comparison Group ◽  
Group Versus ◽  
Psychological Status ◽  
Normal Body Mass Index ◽  
Informed Consent Form ◽  
The Impact

Background:The impact of rheumatic diseases on patients’sexual life has been gathering the attention of the scientific community over the last decade. The existing studies, especially related to fibromyalgia, are scarce.Objectives:To assess the prevalence of sexual dysfunction in women with fibromyalgia followed up at the Outpatient Clinic of the Medical Hospital in Russia.Methods:The main group consisted of 54 women aged from 18 to 55 who sequentially applied for rheumatologist consultation. All subjects fulfilled ACR 2016 Fibromyalgia criteria. The comparison group included 100 healthy women adjusted by age who came for a scheduled health check up and signed the informed consent form. The Female Sexual Function Index (FSFI), obtained by applying a 19-item questionnaire that assesses six domains (sexual desire, arousal, vaginal lubrication, orgasm, sexual satisfaction and pain) and Hospital Anxiety and Depression questionnaire (HADS) were used. The data are presented as means and standard deviations.Results:26 (48,1%) of the patients interviewed reported no sexual activity over the past 4 weeks. fibromyalgia patients reported no sexual activity during the previous 4 weeks. Fibromyalgia group had significantly lower values of all FSFI domains than those of the comparison group: desire 1.98±1.28 and 3.19±1.45; arousal 1.98±1.46 and 3.74±1.45; lubrification 2.35±2.25 and 4.37±1.32; orgasm 1.75±1.68 and 4.06±1.66; satisfaction 2.28±1.19 and 3.95±1.61; no pain 2.49±1.77 and 4.30±1.42. In General, total FSFI score was 12.86±10.97 on fibromyalgia group versus 23.55±8.24 in the healthy group (maximum possible being 36 points, p< 0.0001).We tried to see if sexual function was affected by psychological status or stile of life. We found that only arousal, lubrification, orgasm and satisfaction had minimal values for clinically expressed anxiety while all parameters of sexual dysfunction were reduced in women on fibromyalgia group with borderline and clinically significant depression. There was the best index of sexual function married patients compared to divorced women. Unexpectedly, the minimal scores for all FSFI domains were in the fibromyalgia subgroup of 8 women with body mass deficiency and 20 women with Overweight, while normal body mass index and obesity were protective factors in sexual function.Conclusion:Thus, a significant sexual function decrease was detected in female with fibromyalgia. The most severe dysfunction being associated with the abnormal anxiety, borderline and abnormal depression, divorced status, body mass deficiency and overweight.Disclosure of Interests:None declared

scholarly journals Evaluation of temporal changes in the sexual function among Japanese women using the female sexual function index: An Internet survey

2021 ◽  
Vol 17 ◽  
pp. 174550652110091
Author(s):  
Keiko Okumura ◽  
Hirokazu Takeda ◽  
Toshikazu Otani
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Activity ◽  
Female Sexual Dysfunction ◽  
Japanese Women ◽  
Temporal Changes ◽  
Female Sexual Function Index ◽  
Female Sexual Function ◽  
Sexual Activities ◽  
Function Index

Objectives: Female sexual dysfunction is an underestimated problem that negatively affects women’s quality of life. Although the overall prevalence of sexual dysfunction in women is high, only a few studies have focused on this problem. In Japan, an index of female sexual function has not been clearly defined. Hence, this study aimed to investigate the sexual function of normal Japanese women and the temporal changes they experienced using the Female Sexual Function Index administered online in 2012 and 2019. Methods: The subjects were Japanese women aged 20–79 years registered in an Internet research company. We collected data of 1034 and 2031 women in 2012 and 2019, respectively, based on Japan’s population distribution according to age. Subsequently, we analyzed the collected data using a Japanese version of the Female Sexual Function Index. We investigated the temporal changes in the Female Sexual Function Index total score, the ratio of women who did not engage in sexual activities and women having “no sexual activity” with their partners, and the total Female Sexual Function Index scores according to age. Results: The average Female Sexual Function Index total score decreased from 14.6 in 2012 to 12.5 in 2019 ( p < 0.001). No significant difference was observed in the average Female Sexual Function Index score of the group with sexual activity between 2012 (22.2) and 2019 (22.4). The ratio of women not engaging in sexual activities increased from 42.2% in 2012 to 54.0% in 2019. The ratio of women having “no sexual activity” with their partners increased by 10%. Conclusion: Comparison of data between 2012 and 2019 indicated that Japanese women have become less sexually active. The average Female Sexual Function Index total score of 22 may be useful as a reference value for diagnosing female sexual dysfunction in Japan.

scholarly journals S234. DEPRESSION AND SEXUAL FUNCTIONING: TWO NEGLECTED AND PREVALENT DOMAINS IN PEOPLE WITH SCHIZOPHRENIA

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S127-S128
Author(s):  
Clara Lapa ◽  
Dayane Martins ◽  
Maria Julia Brito ◽  
Ramiro Reckziegel ◽  
Mathias Hasse-Sousa ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Medication Adherence ◽  
Side Effects ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Rating Scale ◽  
Psychiatric Symptoms ◽  
Sexual Experience ◽  
Depression Symptoms ◽  
Chronic Patients

Abstract Background Sexual function is highly neglected in individuals with schizophrenia (SZ). Clinicians usually underestimate the rates of sexual dysfunctions in these patients, and this group does not spontaneously complain about it. Sexual dysfunction in this population could reach up to 80% and its known to affect all domains of sexual function. Moreover, it may be linked to stigma and discrimination factors. Medication side effects on sexuality concern more than any other side effects, and it is known to be a major cause of poor quality of life and non-adherence to medication. Furthermore, the relationship between sexual dysfunction and other psychiatric symptoms in SZ is still unclear. Our aim was to describe the sexual dysfunction in chronic patients with SZ and its relation to negative, positive and depressive symptoms. Methods A convenience and exploratory sample of 57 patients (age 43.75±10.38, 69% men, 86,2% single) were recruited from an university outpatient schizophrenia clinic, in Porto Alegre – Brazil. Participants were assessed using Arizona Sexual Experience Scale (ASEX), Medication Adherence Rating Scale (MARS), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Inventory and demographic information. Sexual dysfunction was considered following the ASEX scoring criteria. Results Sexual dysfunction was present in 51,8% of the patients, assessed by ASEX. Women showed increased sexual dysfunction than men (χ2=22,727, p &lt; .001). There were no differences between patients that reported sexual dysfunction and the ones who did not regarding age, duration of illness and medication adherence assessed by MARS (p &gt; .05). Additionally, there were no differences between groups on positive and negative symptoms assessed by PANSS. Interestingly, patients with sexual dysfunction had increased depressive symptoms compared to patients with a good perceived sexual function (t(54) = -3.326, p = .002). Calgary total scores were positively correlated with ASEX total scores (r = .369, p = .005). Nevertheless, we did not find significant correlations between ASEX total scores and other scales. Scores found on MARS (8.07±1.5) suggest that this sample is highly adherent to prescribed treatment. Discussion This is an exploratory and preliminary study that shows and reinforces the idea that sexual dysfunction is importantly prevalent and remains as a neglected issue in individuals with schizophrenia, as are the depressive symptoms. We showed that there is an association between these two domains, which might indicate a need for change of perspective for the pharmacological and psychosocial approaches currently used. In addition to the dopaminergic blockage by antipsychotics that lead to reduction in positive symptoms, we believe there is a need to look for depression symptoms to access, prevent and treat sexual dysfunction. Inattention to this event may result in abrupt treatment discontinuation and relapse. Curiously, the fact that we did not find any correlations between sexual evaluations and PANSS scores would suggest that sexual dysfunction in chronic patients could differ from others stages of the disease. The size of our sample and the fact that we did not access hormones and prolactin levels are important limitations of this study. However this is an exploratory study that provided clues on the subject, allowing to address further investigation taking into account the limitations.

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