scholarly journals FEATURES OF ASSESSING THE SEXUAL BEHAVIOR OF MALE RATS IN THE STUDY OF THE EFFECTS OF COMPOUNDS THAT HAVE A STIMULATING EFFECT ON SEXUAL FUNCTION

2020 ◽  
Author(s):  
Svetlana N. Subbotina ◽  
Anastasiya A. Kryazhevskikh ◽  
Aleksey A. Kryazhevskikh ◽  
Mikhail A. Yudin ◽  
Elizaveta I. Eletskaya
Keyword(s):  
Sexual Behavior ◽  
Sexual Function ◽  
Sexual Activity ◽  
Mechanism Of Action ◽  
Experimental Models ◽  
Central Mechanism ◽  
Male Rats ◽  
Test Duration ◽  
Pharmacological Agents

The paper presents a comparative analysis of information content of methods for assessing the copulatory behavior of male rats with the introduction of compounds that have a stimulating effect on the sexual activity of animals. The social significance of the problem of sexual dysfunctions determines the relevance of the development of various experimental models of sexual behavior that allow assessing the effectiveness and safety of new drug. The probability of detecting the activating effect of pharmacological agents on sexual activity directly depends on the correct choice of the experimental model. The drugs of the central mechanism of action galantamine hydrobromide (1mg/kg) and loxidan (1,7mg/kg), were used as pharmacological agents; drugs of peripheral action were yohimbine hydrochloride (2,6mg/kg) and vardenafil hydrochloride (1,7mg/kg). It has been shown that the determination of the stimulating effects of compounds of the central mechanism of action is possible using methods with different testing duration (from 15 to 180min). Thus, the introduction of galantamine enhances the sexual activity of males in terms of the copulation rate, the number of perfect ejaculations and the duration of the post-ejaculatory refractory period, loxidan in terms of the total number of intromissions and relative rest time in tests of limited duration. In the test showing the completed sexual cycle of males, the stimulating effects of galantamine are shown in terms of the number of completed copulatory series and the number of completed ejaculations. To assess the activating effects of compounds of the peripheral mechanism of action, the expediency of using experimental models with a test duration of 30 minutes or more was shown. The most informative test is the test of paired interaction between a male and a female until the male reaches the state of sexual exhaustion. A method with high information content is presented, which provides a high probability of detecting the activating effect of compounds on the sexual function of male rats. Determination of the stimulating effects of compounds of the central mechanism of action is possible using methods with different test duration

scholarly journals Changes in the motivational component of sexual function in the offspring of rats after prenatal exposure to cholinotropic drugs

2020 ◽  
Vol 18 (1) ◽  
pp. 29-36
Author(s):  
Elena V. Stashina ◽  
Artur O. Zelener ◽  
Alekber A. Bairamov ◽  
Petr D. Shabanov
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Activity ◽  
Prenatal Exposure ◽  
Sexual Experience ◽  
Male Rats ◽  
Dopaminergic Systems ◽  
The Brain ◽  
Sexually Mature

Prenatal exposure to N-cholinoblocker gangleron and in lesser degree to M-cholinoblocker metamisil leads to significant violations of the motivational component of sexual function in sexually mature offspring of males, expressed in low values of primary sexual activity, and increased latency of the approach and sexual dysfunction after the acquisition of sexual experience. Among the causes of sexual dysfunction in the offspring, it can be noted a change in the hormonal background in male rats, in the form of a significant decrease in the level of the main androgen testosterone, as well as damage in the dopaminergic systems of the brain, manifested by a decrease in dopamine levels.

A Strong Pelvic Floor is Associated with Higher Rates of Sexual Activity and Improved Sexual Function

2014 ◽  
Vol 21 (2) ◽  
pp. S19 ◽  
Author(s):  
G. Kanter ◽  
R. Rogers ◽  
R.N. Pauls ◽  
R. Thakar ◽  
D. Kammerer-Doak
Keyword(s):  
Sexual Function ◽  
Pelvic Floor ◽  
Sexual Activity

scholarly journals Beneficial effect of retigabine on memory in rats receiving ethanol

2020 ◽  
Author(s):  
Ewa Zwierzyńska ◽  
Agata Krupa-Burtnik ◽  
Bogusława Pietrzak
Keyword(s):  
Beneficial Effect ◽  
Fear Conditioning ◽  
Morris Water Maze ◽  
Water Maze ◽  
Experimental Models ◽  
Male Rats ◽  
Ethanol Administration ◽  
Free Access ◽  
Oral Gavage ◽  
The Impact

Abstract Background Retigabine belongs to the novel generation of antiepileptic drugs but its complex mechanism of action causes that the drug might be effective in other diseases, for instance, alcohol dependence. It is known that ethanol abuse impaired the function of brain structures associated with memory and learning such as the hippocampus. In our previous study, retigabine reduced hippocampal changes induced by ethanol in the EEG rhythms in rabbits. This study is focused on the impact of retigabine on memory processes in male rats receiving alcohol. Methods Memory was evaluated in various experimental models: Morris water maze, Contextual, and Cued Fear Conditioning tests. Retigabine was administered for 3 weeks directly to the stomach via oral gavage at a dose of 10 mg/kg. Rats received also 20% ethanol (5 g/kg/day in two doses) via oral gavage for 3 weeks and had free access to 5% ethanol in the afternoon and at night. Morris water maze was performed after 1 and 3 weeks of ethanol administration and after 1 week from the discontinuation of ethanol administration. Contextual and Cued Fear Conditioning tests were carried out after 24 h and 72 h of alcohol discontinuation. Results The drug significantly decreased ethanol-induced memory disturbances during alcohol administration as well as slightly improved learning processes after the discontinuation of ethanol administration. Conclusions This beneficial effect of retigabine-ethanol interaction on memory may be a relevant element of the drug’s impact on the development of addiction.

scholarly journals Sexual Health in Spanish People with Intellectual Disability: the Impact of the Lockdown due to COVID-19

2021 ◽  
Author(s):  
M. Dolores Gil-Llario ◽  
Irene Díaz-Rodríguez ◽  
Vicente Morell-Mengual ◽  
Beatriz Gil-Juliá ◽  
Rafael Ballester-Arnal
Keyword(s):  
Sexual Abuse ◽  
Sexual Behavior ◽  
Sexual Health ◽  
Intellectual Disabilities ◽  
Sexual Activity ◽  
Policy Implications ◽  
The People ◽  
People With Intellectual Disabilities ◽  
Technological Improvements ◽  
The Impact

Abstract Introduction The lockdown due to COVID-19 affected the sexual health of the people with intellectual disabilities by differentially modifying the frequency and characteristics of people’s sexual activity depending on whether or not they lived with a partner during this period. The aim of this study was to analyze the extent to which the sexual behavior of people with intellectual disabilities (with and without a partner) was affected during the lockdown. Methods The sample consisted of 73 people with intellectual disabilities between 21 and 63 years old (M = 39.63; SD = 10.11). The variables analyzed were the physical, social, and technological environment during the lockdown, sexual appetite, sexual behavior, online sexual activity, and sexual abuse. The data were collected between the months of May and June of 2020. Results The lockdown increased the sexual appetite of a third of the sample (38%), especially the youngest participants. Sexual activity focused on autoeroticism and online behavior, particularly sending nude images of oneself (88%) and viewing pornography (83.6%). Rates of sexual abuse during this period were relatively high (6.8%). Conclusions The sexual activity of people with ID was important during the lockdown, and they had to adapt to the circumstances of isolation in a similar way to the general population. Technological improvements in terms of devices and connection quality at home allowed their sexual behavior to be reoriented, opening the door to new risks for the sexual health of people with ID. Policy Implications Cybersex and the increase in sexual abuse due to confinement are aspects that should be included in programs to improve the sexual health of this group.

Serotonin stimulates GH secretion through a direct pituitary action: studies in hypophysectomized autografted animals and in perifused pituitaries

1986 ◽  
Vol 113 (3) ◽  
pp. 317-322 ◽  
Author(s):  
F. López ◽  
D. Gónzalez ◽  
E. Aguilar
Keyword(s):  
Plasma Volume ◽  
Direct Action ◽  
Experimental Models ◽  
Male Rats ◽  
Blood Samples ◽  
Kidney Capsule ◽  
Gh Secretion ◽  
Significant Release ◽  
The Right ◽  
Dose Dependent

Abstract. To analyze a possible direct action of serotonin (5-hydroxytryptamine) at pituitary level in GH secretion, two experimental models were used: hypophysectomized autografted rats and perifused pituitaries. Adult male rats were hypophysectomized and their own pituitaries placed under the right kidney capsule. Ten days later an intra-atrial cannula was inserted. The next day, blood samples were obtained before and every 10 min during a 2 h period after the injection of saline or 5-hydroxytryptamin (1 or 2 mg/kg iv). Plasma volume was replaced with saline. Both doses of 5-hydroxytryptamine elicit a strong release of GH, the effect being dose-dependent. In pituitaries perifused with 5-hydroxytryptamine (100 μm during 115 min or 1, 10 and 100 μm during 15 min), a significant release of GH was also observed. These results suggested that 5-hydroxytryptamine may stimulate GH secretion through a direct pituitary action.

Disruption of sexual behavior in socially isolated adult male rats

1982 ◽  
Vol 34 (2) ◽  
pp. 215-220 ◽  
Author(s):  
Kathleen C. Chambers ◽  
Cord B. Sengstake ◽  
Anne M. Walther ◽  
Judith E. Bullis
Keyword(s):  
Sexual Behavior ◽  
Adult Male ◽  
Male Rats ◽  
Socially Isolated
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