scholarly journals Breathing disorders during sleep in premature infants with broncopulmonary dysplasia and pulmonary hypertension

2017 ◽  
Vol 8 (6) ◽  
pp. 5-10
Author(s):  
Anna Yu. Solomakha ◽  
Natalia A. Petrova ◽  
Dmitry O. Ivanov ◽  
Yurii V. Sviryaev

Infants with severe and moderate bronchopulmonary dysplasia (BPD) are characterized by long-term persistence of apnea of prematurity, mainly central genesis, and more significant decrease of ЅрО2. The aim of our study was to assess the character and severity of breathing disorders during sleep in infants the first year of life, born prematurely and having BPD complicated by PH. Were examined 40 infants who were born at 23-31 weeks of gestation, weight at birth less than 1700 g. 31 infants had BPD (mild form was diagnosed in 9 infants, moderate form – in 12 infants and severe form – in 10 infants), 11 infants had BPD complicated by PH. Patients were divided into 3 groups. The first group was made up of the infants without BPD. The second group includes infants with BPD, and 3 group was made up of the infants with BPD complicated by PH. Cardiorespiratory monitoring was performed immediately before discharge from hospital (35-43 weeks post-menstrual age) (infants had not been routine monitored for at list 5 days and had not been received oxygen for at list 8 days). We used “The brief screening questionnaire for infants with sleep problems”, developed by A. Sadeh (author's permission to use the questionnaires was received), as the screening of disorders of sleep in infants. The result was obtained the comparative characteristics of cardiorespiratory indices in the groups of infants and evaluated the character and severity of breathing disorders during sleep, made testing applications screening questionnaire.

2018 ◽  
Vol 9 (3) ◽  
pp. 16-23
Author(s):  
Anna Yu. Solomakha ◽  
Natalia A. Petrova ◽  
Dmitry O. Ivanov ◽  
Yurii V. Sviryaev

Infants with severe and moderate bronchopulmonary dysplasia (BPD) are characterized by long-term persistence of apnea of prematurity and often have a pulmonary hypertension (PH). Respiratory pauses, accompanied by intermittent hypoxia, do not clinically manifest themselves, therefore cardiorespiratory monitoring (CRM) is required. We hypothesized that the persistent of apnea, as the cause of hypoxemia episodes, may be associated with the persistence of PH in infants with BPD. The aim of the study was to evaluate the dynamics of cardiorespiratory parameters and to study the relationship between obstructive apnea and PH during the first year of life of premature infants with BPD + PH. Materials and methods. CRM was performed in 58 infants were born at 26 0/7-31 0/7 weeks gestation and with birth weight less than 1500 grams, before discharge from the hospital (35-44 weeks of post menstrual age). 14 infants did not have BPD (group without BPD). 44 infants had BPD and 17 of them had a complication of this disease PH (BLD + PH group). Other infants with BPD did not have PH (BLD-PH group). Eight infants with BPD also underwent a study at home (aged 9 to 10 months of life). Results. Preterm infants with BPD + PH were more significant decrease in the average SpO2, higher desaturation index and more a number of desaturation episodes of <10% compared to infants with BPD-PH and without BPD. There was no difference in the apnea/hypopnea index and frequency of occurrence of different types of apnea between groups. There was no difference in cardiorespiratory performance in infants with BPD+PH compared to infants with BPD-PH in 9-10 months of life. Conclusions. There was a positive dynamics of cardiorespiratory parameters in infants with BPD+PH in 9-10 months after discharge from the hospital. The number of infants with an index of OA> 1/hour is higher in the group BPD+LH.


2018 ◽  
Vol 97 (3) ◽  
pp. 24-28
Author(s):  
M.R. Tumanyan ◽  
◽  
A.A. Svobodov ◽  
E.G. Levchenko ◽  
A.G. Anderson ◽  
...  

2019 ◽  
Vol 24 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Bianca K. den Ottelander ◽  
Robbin de Goederen ◽  
Marie-Lise C. van Veelen ◽  
Stephanie D. C. van de Beeten ◽  
Maarten H. Lequin ◽  
...  

OBJECTIVEThe authors evaluated the long-term outcome of their treatment protocol for Muenke syndrome, which includes a single craniofacial procedure.METHODSThis was a prospective observational cohort study of Muenke syndrome patients who underwent surgery for craniosynostosis within the first year of life. Symptoms and determinants of intracranial hypertension were evaluated by longitudinal monitoring of the presence of papilledema (fundoscopy), obstructive sleep apnea (OSA; with polysomnography), cerebellar tonsillar herniation (MRI studies), ventricular size (MRI and CT studies), and skull growth (occipital frontal head circumference [OFC]). Other evaluated factors included hearing, speech, and ophthalmological outcomes.RESULTSThe study included 38 patients; 36 patients underwent fronto-supraorbital advancement. The median age at last follow-up was 13.2 years (range 1.3–24.4 years). Three patients had papilledema, which was related to ophthalmological disorders in 2 patients. Three patients had mild OSA. Three patients had a Chiari I malformation, and tonsillar descent < 5 mm was present in 6 patients. Tonsillar position was unrelated to papilledema, ventricular size, or restricted skull growth. Ten patients had ventriculomegaly, and the OFC growth curve deflected in 3 patients. Twenty-two patients had hearing loss. Refraction anomalies were diagnosed in 14/15 patients measured at ≥ 8 years of age.CONCLUSIONSPatients with Muenke syndrome treated with a single fronto-supraorbital advancement in their first year of life rarely develop signs of intracranial hypertension, in accordance with the very low prevalence of its causative factors (OSA, hydrocephalus, and restricted skull growth). This illustrates that there is no need for a routine second craniofacial procedure. Patient follow-up should focus on visual assessment and speech and hearing outcomes.


2021 ◽  
Author(s):  
Jordan R. Salley ◽  
Yann‐Fuu Kou ◽  
Gopi B. Shah ◽  
Romaine F. Johnson

PEDIATRICS ◽  
1960 ◽  
Vol 25 (6) ◽  
pp. 967-976
Author(s):  
R. A. Parker ◽  
Carolyn F. Piel

The clinical course of nephrosis in five infants with onset of disease before 7 months of age is presented, together with evaluation of renal lesions seen at necropsy. The problems of the management of nephrosis susceptibility to infection and water and electrolyte imbalance were found to be exaggerated by the young age of the patients. The renal pathology observed in these five infants consisted of persistence of immature glomeruli and dilatation of the tubules in the cortical area. Later, the immature glomeruli and associated tubules appear to atrophy and the remaining glomeruli to hypertrophy. Long-term adrenocorticosteroid therapy seems to be contraindicated, not only on the basis of the pathologic changes, but because it greatly exaggerates the problems of management and does not effect a remission of the disease.


1997 ◽  
Vol 117 (2) ◽  
pp. 206-207 ◽  
Author(s):  
R. J. Ruben ◽  
I. F. Wallace ◽  
J. Gravel

2008 ◽  
Vol 93 (7) ◽  
pp. 582-589 ◽  
Author(s):  
N U Gerber ◽  
D Zehnder ◽  
T J Zuzak ◽  
A Poretti ◽  
E Boltshauser ◽  
...  

1978 ◽  
Vol 81 (1) ◽  
pp. 125-130 ◽  
Author(s):  
M. L. Burr ◽  
C. H. L. Howells ◽  
P. W. J. Rees

SUMMARYNasal swabs were taken from 492 babies born consecutively to residents of two South Wales towns soon after their discharge from maternity hospitals. Staphylococcus aureus was isolated from 352 babies (72%) and in 79 (22%) of these it was resistant to at least one antibiotic. By the time these babies were a year old the prevalence of both sensitive and resistant strains had fallen, so that only 12% still carried nasal staphylococci, but 64% of these organisms were then resistant to penicillin. Administration of penicillin to the baby seemed to be a more important factor in selecting resistant organisms than other antibiotics given to the baby, any antibiotic treatment to other members of the household, or discharge from hospital.


Nutrition ◽  
2000 ◽  
Vol 16 (11-12) ◽  
pp. 1056-1063 ◽  
Author(s):  
Daniza M Ivanovic ◽  
Boris P Leiva ◽  
Hernan T Perez ◽  
Nelida B Inzunza ◽  
Atilio F Almagià ◽  
...  

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