Opportunities electroretinography in stadying of physiological stages of maturation human retina at different ages

2014 ◽  
Vol 5 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Olga Aleksandrovna Konikova ◽  
Vladimir Vsevolodovich Brzheskiy
Keyword(s):  
Early Childhood ◽  
Healthy Children ◽  
Human Retina ◽  
Distinctive Features ◽  
Formation Curve ◽  
Cone Function ◽  
Different Ages ◽  
Rod Function ◽  
Typical Configuration ◽  
Low Amplitude

The results of evaluation of the functional state of the retina in 55 healthy children of different ages (110 eyes). Distinctive features of the formation curve electroretinogram in early childhood. So in children under 6 months a-wave electroretinogram was not recorded, b-wave had a very low amplitude and increased latency. Typical configuration electroretinogramm was after 1 year of life. Noted that the maturation of cone function finishes later than the rod-function. Electroretinography objectively confirm phasing formation of functional activity of the visual system in children.

scholarly journals Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sara Pischedda ◽  
Daniel O’Connor ◽  
Benjamin P. Fairfax ◽  
Antonio Salas ◽  
Federico Martinon-Torres ◽  
...  
Keyword(s):  
Early Childhood ◽  
Immune System ◽  
T Cell Activation ◽  
Specific Antibody ◽  
Cell Activation ◽  
Pneumococcal Vaccination ◽  
Antibody Responses ◽  
Healthy Children ◽  
Epigenetic Changes ◽  
Pneumococcal Infections

Abstract Background Pneumococcal infections are a major cause of morbidity and mortality in young children and immaturity of the immune system partly underlies poor vaccine responses seen in the young. Emerging evidence suggests a key role for epigenetics in the maturation and regulation of the immune system in health and disease. The study aimed to investigate epigenetic changes in early life and to understand the relationship between the epigenome and antigen-specific antibody responses to pneumococcal vaccination. Methods The epigenetic profiles from 24 healthy children were analyzed at 12 months prior to a booster dose of the 13-valent pneumococcal conjugate vaccine (PCV-13), and at 24 months of age, using the Illumina Methylation 450 K assay and assessed for differences over time and between high and low vaccine responders. Results Our analysis revealed 721 significantly differentially methylated positions between 12 and 24 months (FDR < 0.01), with significant enrichment in pathways involved in the regulation of cell–cell adhesion and T cell activation. Comparing high and low vaccine responders, we identified differentially methylated CpG sites (P value < 0.01) associated with HLA-DPB1 and IL6. Conclusion These data imply that epigenetic changes that occur during early childhood may be associated with antigen-specific antibody responses to pneumococcal vaccines.

Streptococcus Mutans Strains in Mother-Child Pairs of Children with Early Childhood Caries

2019 ◽  
Vol 43 (4) ◽  
pp. 252-256 ◽  
Author(s):  
Priya Subramaniam ◽  
Revathy Suresh
Keyword(s):  
Early Childhood ◽  
Dental Caries ◽  
Streptococcus Mutans ◽  
Early Childhood Caries ◽  
Mutans Streptococci ◽  
Similar Distribution ◽  
Healthy Children ◽  
Only Children ◽  
Polymerase Chain ◽  
Childhood Caries

Objective: Dental caries is both an infectious and transmissible disease. Maternal transfer of Mutans Streptococci occurs at an early age and is important in the initiation of dental caries in children. The aim of this study was to identify certain strains of Streptococcus mutans in mother-child pairs, of children with early childhood caries. Study design: Sixty mother-child pairs of healthy children aged 18–36 months were selected. Mothers with high levels of Streptococcus mutans in their saliva and only children with ECC were included. Dental plaque samples were collected from mother-child pairs. The plaque samples were stored, transferred to the laboratory and analyzed for Streptococcus mutans strains c, f, e and k, present in mother-child pairs using Real time Polymerase Chain Reaction (PCR) technique. Data obtained was subjected to statistical analysis for level of similarity in Streptococcus mutans strains present in mother-child pairs. Results: A similar distribution of Streptococcus mutans strains c, f and k was identified in 28 mother-child pairs. Streptococcus mutans strain e was seen in 18 pairs. Conclusion: Less than 50% of mother-child pairs showed similarity in distribution of Streptococcus mutans strains.

scholarly journals Developmental Changes in Ultradian Sleep Cycles across Early Childhood

2017 ◽  
Vol 32 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Sean Lopp ◽  
William Navidi ◽  
Peter Achermann ◽  
Monique LeBourgeois ◽  
Cecilia Diniz Behn
Keyword(s):  
Early Childhood ◽  
Rem Sleep ◽  
Nrem Sleep ◽  
Developmental Model ◽  
Cycle Duration ◽  
Healthy Children ◽  
Nocturnal Sleep ◽  
Quiet Sleep ◽  
Number Of Cycles ◽  
Sleep Cycles

Nocturnal human sleep is composed of cycles between rapid eye movement (REM) sleep and non-REM (NREM) sleep. In adults, the structure of ultradian cycles between NREM and REM sleep is well characterized; however, less is known about the developmental trajectories of ultradian sleep cycles across early childhood. Cross-sectional studies indicate that the rapid ultradian cycling of active-quiet sleep in infancy shifts to a more adult-like pattern of NREM-REM sleep cycling by the school-age years, yet longitudinal studies elucidating the details of this transition are scarce. To address this gap, we examined ultradian cycling during nocturnal sleep following 13 h of prior wakefulness in 8 healthy children at 3 longitudinal points: 2Y (2.5-3.0 years of age), 3Y (3.5-4.0 years of age), and 5Y (5.5-6.0 years of age). We found that the length of ultradian cycles increased with age as a result of increased NREM sleep episode duration. In addition, we observed a significant decrease in the number of NREM sleep episodes as well as a nonsignificant trend for a decrease in the number of cycles with increasing age. Together, these findings suggest a concurrent change in which cycle duration increases and the number of cycles decreases across development. We also found that, consistent with data from adolescents and adults, the duration of NREM sleep episodes decreased with time since lights-off whereas the duration of REM sleep episodes increased over this time period. These results indicate the presence of circadian modulation of nocturnal sleep in preschool children. In addition to characterizing changes in ultradian cycling in healthy children ages 2 to 5 years, this work describes a developmental model that may provide insights into the emergence of normal adult REM sleep regulatory circuitry as well as potential trajectories of dysregulated ultradian cycles such as those associated with affective disorders.

scholarly journals Prevalence of Hepatitis E Virus Infection in Children in the Northeast of Spain

2008 ◽  
Vol 15 (4) ◽  
pp. 732-734 ◽  
Author(s):  
Maria Buti ◽  
Pere Plans ◽  
Angela Domínguez ◽  
Rossend Jardi ◽  
Francisco Rodriguez Frias ◽  
...  
Keyword(s):  
Early Childhood ◽  
Virus Infection ◽  
Immunoglobulin G ◽  
Representative Sample ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Healthy Children

ABSTRACT The prevalence of immunoglobulin G (IgG) anti-hepatitis E virus (anti-HEV) antibodies was studied with a representative sample of 1,249 healthy children aged between 6 and 15 years. IgG anti-HEV antibodies were detected in 57 (4.6%) of the 1,249 samples analyzed, suggesting that some children are exposed to HEV in early childhood.

scholarly journals Effect of Early Childhood Malnutrition on Tooth Eruption Sequence in Nepalese Children

2020 ◽  
Vol 35 (2) ◽  
pp. 22-33
Author(s):  
Nameeta Shrestha ◽  
J. Acharya
Keyword(s):  
Early Childhood ◽  
Tooth Eruption ◽  
Chronic Illnesses ◽  
Caries Experience ◽  
Healthy Children ◽  
Childhood Malnutrition ◽  
Under Nutrition ◽  
Malnourished Children ◽  
Decayed Tooth ◽  
Delayed Eruption

Child under-nutrition has effects which last a lifetime. The consequences can be both short term and long term. Malnourished children tend to be physically, emotionally and intellectually less productive and suffer more from chronic illnesses and disabilities compared to healthy children. The objective of this study was to determine prevalence of under-nutrition and investigate association between early childhood malnutrition and deciduous tooth eruption in children aged 0-59 months in Mugu district of Nepal. A structured questionnaire based on Nepal Demographic and Health Survey 2011 questionnaire was used. Weight and height of 246 children, aged 0-59 months were measured. Dental caries status and eruption sequence were noted. Among the total, 14 .1% had moderate/severe wasting of muscles, 25.2% were moderately stunted and 36.6% were severely stunted. From the total, 30 .5% were moderately underweight and 18.3% were severely underweight. A significantly higher proportion with wasting presented with delayed eruption sequence than those without wasting (p <0.05). From the total, 25.4% who presented with delayed eruption also had at least one decayed tooth (p><0.05). From this study, it was concluded that malnutrition causes delayed tooth eruption, affects the oral health of the child, and results in an increased caries experience.

scholarly journals Calcium and Inorganic Phosphorous Levels in Stimulated and Unstimulated Saliva in Early Childhood Caries – A Comparative Study

2014 ◽  
Vol 1 (2) ◽  
pp. 5
Author(s):  
Lisa R. Jolly ◽  
Amarshree Shetty
Keyword(s):  
Early Childhood ◽  
Early Childhood Caries ◽  
Calcium Concentration ◽  
Calcium Hydroxyapatite ◽  
Healthy Children ◽  
Unstimulated Saliva ◽  
The Mean ◽  
Inorganic Phosphorous ◽  
Phosphorous Concentration ◽  
Childhood Caries

<strong>Introduction</strong>: Saliva, a chief player in the oral cavity, is determined by its secretion rate and quality to aid either in the development of caries, or its remineralization. The ability for saliva to function as a source of calcium and phosphate increases its supportive properties as it influences the precipitation or dissolution of calcium hydroxyapatite (HAP), the principal inorganic component of dental hard tissue.<p><strong>Materials&amp;Methods</strong>: 30 healthy children, aged between 3 and 6 years old were screened and recruited for the study at the Department of Pedodontics and Preventive Dentistry of the A.B Shetty Memorial Institute of Dental Sciences, a constituent of Nitte University. The subjects were clinically examined and scored based on their decayed, missing (due to caries) and filled surfaces (dfs) and were further categorized into two equal groups of 15.</p><p><strong>Result</strong>: In the subjects with Early Childhood Caries (ECC), the mean calcium concentration in samples of unstimulated saliva was 4.2383 ± 0.8594 and in samples of stimulated saliva was 4.1965 ± 0.6240. While, the mean inorganic phosphorous concentration in samples of unstimulated saliva was 3.219 ± 0.8540and in samples of stimulated saliva was 3.0634 ± 0.5470.</p><p><strong>Conclusion</strong>: From this study, we obtained a relationship between calcium, saliva and the caries status of children with the calcium concentration decreasing with increase in the caries status, as well as on stimulation of saliva.</p>

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