scholarly journals Analysis of T helper and antigen-presenting cell functions in cord blood and peripheral blood leukocytes from healthy children of different ages.

1993 ◽  
Vol 91 (6) ◽  
pp. 2829-2836 ◽  
Author(s):  
M Clerici ◽  
L DePalma ◽  
E Roilides ◽  
R Baker ◽  
G M Shearer
Keyword(s):  
Cord Blood ◽  
Peripheral Blood ◽  
Healthy Children ◽  
Peripheral Blood Leukocytes ◽  
T Helper ◽  
Antigen Presenting Cell ◽  
Blood Leukocytes ◽  
Cell Functions ◽  
Different Ages ◽  
Antigen Presenting

scholarly journals INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS

2018 ◽  
Vol 20 (6) ◽  
pp. 865-870
Author(s):  
L. M. Kurtasova ◽  
N. A. Shakina ◽  
A. R. Smidt ◽  
L. A. Ikkes
Keyword(s):  
Infectious Mononucleosis ◽  
Peripheral Blood ◽  
Healthy Children ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
In Vitro Susceptibility ◽  
Barr Virus ◽  
Epstein Barr ◽  
Interferon Α2

Our aim was to study the effect of cycloferon on in vitro susceptibility of peripheral blood leukocytes to interferon-α2 in children with infectious mononucleosis in acute phase caused by Epstein-Barr virus (EBV). Materials and methods were as follows: the study included 23 children 4 to 6 years of age admitted in acute period of infectious mononucleosis. The control group consisted of 15 healthy children of the same age group. In vitro susceptibility of peripheral blood leukocytes to interferon-α2 was determined by the method of L.M. Kurtasova (2007).Four types of in vitro response of peripheral blood leukocytes to interferon-α2 upon induction by cycloferon have been revealed in both healthy children and patients with EBV-positive infectious mononucleosis. Differences in occurrence rates of these 4 types of reactions have been found among patients with EBVinfection, in comparison with the group of healthy children. There was no regular dose-dependent changes in susceptibility of peripheral blood  leukocytes to interferon-α2 in vitro after cycloferon induction in the group of children with EBV-infection. depending on the dose, which have been revealed in healthy children.

scholarly journals Infusion of donor-derived peripheral blood leukocytes after transplantation of cord blood progenitor cells can increase the graft-versus-leukaemia effect

Leukemia ◽  
1997 ◽  
Vol 11 (5) ◽  
pp. 729-731 ◽  
Author(s):  
F Locatelli ◽  
P Comoli ◽  
G Giorgiani ◽  
AM Carrà ◽  
G Di Giulio ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes

FUNCTIONING OF NO-SYNTHASE IN THE PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH ACNE VULGARIS

2018 ◽  
Vol 14 (66) ◽  
pp. 075
Author(s):  
H. S. Lavryk ◽  
O. P. Korniychuk ◽  
Z. Ya. Fedorovych ◽  
Z. D. Vorobets
Keyword(s):  
Peripheral Blood ◽  
Acne Vulgaris ◽  
No Synthase ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes

A Dinucleotide Deletion in the CD24 Gene Is a Potential Risk Factor for Colorectal Cancer

2020 ◽  
Vol 86 (5) ◽  
pp. 480-485
Author(s):  
Lior Segev ◽  
Ilana Naboishchikov ◽  
Diana Kazanov ◽  
Ezra Bernstein ◽  
Meital Shaked ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Peripheral Blood ◽  
Intracellular Signaling ◽  
Genetic Variant ◽  
Colorectal Carcinogenesis ◽  
Polymorphism Analysis ◽  
Peripheral Blood Leukocytes ◽  
Clinical Value ◽  
Blood Leukocytes ◽  
Multistep Process

Background CD24 is a sialoglycoprotein anchored to the cell surface via glycosylphosphatidylinositol and is involved in intracellular signaling processes. It plays an important role in the early stages of the multistep process of colorectal carcinogenesis. Several single nucleotide polymorphisms in the CD24 gene are reported to exert a diverse effect on cancer risk. We aimed to elucidate whether CD24 TG/del genetic variants are associated with susceptibility to colorectal cancer (CRC). Methods The study included 179 subjects, 36 with CRC (prior to surgery) and 143 healthy control subjects. Deoxyribonucleic acid was purified from peripheral blood leukocytes, and by using restriction fragment length polymorphism analysis, the CD24 gene was genotyped for the specific genetic variant, TG deletion. Additionally, CD24 protein expression levels were determined by Western blotting analysis. Results The incidence of the TG/del was higher among the CRC patients compared with healthy controls, 14% and 10%, respectively ( P = .54). CD24 protein levels were significantly higher among CRC patients. There were no significant differences in CD24 expression between CRC patients at different stages of the disease or between patients who carry the mutation and those who did not. Conclusions CD24 genetic variant might be of clinical value for risk assessment as part of cancer prevention programs. Further study on larger populations is needed to validate the importance of this dinucleotide deletion in CRC development. Overexpression of CD24 protein occurs early along the multistep process of CRC carcinogenesis, and a simple blood sample based on CD24 expression on peripheral blood leukocytes can contribute to early diagnosis.

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