scholarly journals Choroidal thickness in normal subjects and in age-related macular degeneration

2014 ◽  
Vol 7 (1) ◽  
pp. 4-7
Author(s):  
Yuriy Sergeyevich Astakhov ◽  
Svetlana Georgiyevna Belekhova ◽  
Nikita Yuryevich Dal
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Age Groups ◽  
Normal Subjects ◽  
Age Related Macular Degeneration ◽  
Enhanced Depth Imaging ◽  
Foveal Thickness ◽  
Age Related ◽  
Thickness Measurements ◽  
Optical Coherence Tomograph

Results of choroidal thickness measurements in 75 healthy subjects of different age groups (123 eyes) are presented as well as those of 35 patients (45 eyes) with age-related macular degeneration. Examinations were performed with a Spectralis optical coherence tomograph using the regimen of Enhanced Depth Imaging (EDI-OCT). A negative dependence between choroidal thickness and age was found (r = -0.78, p < 0.0001). Sub-foveal thickness of the choroid decreases on average by 2.99 µm for every life year. No significant differences in choroidal thickness of age-related macular degeneration patients and that of healthy people of the same age group were found.

scholarly journals Choroidal thickness changes in age-related macular degeneration different forms and stages

2015 ◽  
Vol 8 (3) ◽  
pp. 13-19
Author(s):  
Svetlana Georgievna Belekhova ◽  
Yury Sergeevich Astakhov
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Thickness Measurement ◽  
Healthy People ◽  
Age Related Macular Degeneration ◽  
Enhanced Depth Imaging ◽  
Depth Imaging ◽  
Age Related ◽  
Measurement Results ◽  
Wet Amd

Choroidal thickness measurement results of 124 patients (210 eyes) with age-related macular degeneration (AMD) obtained by enhanced depth imaging of spectral domain optical coherence tomography (EDI-OCT) are presented. There were no significant differences in choroidal thickness between patients with dry and wet AMD forms and healthy people of the same age group (р = 0.67; р = 0.26). A statistically significant choroidal thinning in patients with late AMD stages as compared to each of healthy people and dry and wet AMD patients was found (р < 0.0001).

Choroidal Thickness and Visual Prognosis in Type 1 Lesion Due to Neovascular Age-Related Macular Degeneration

2016 ◽  
Vol 27 (2) ◽  
pp. 196-200 ◽  
Author(s):  
Pablo Hernández-Martínez ◽  
Rosa Dolz-Marco ◽  
David Hervás-Marín ◽  
Maria Andreu-Fenoll ◽  
Roberto Gallego-Pinazo ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Age Related Macular Degeneration ◽  
Intravitreal Injections ◽  
Enhanced Depth Imaging ◽  
Subfoveal Choroidal Thickness ◽  
Age Related

Purpose To evaluate the association between subfoveal choroidal thickness and the visual outcome in eyes with type 1 choroidal neovascularization (CNV) due to neovascular age-related macular degeneration (nAMD). Methods This was a retrospective, longitudinal, cross-sectional study including patients diagnosed with nAMD type 1 lesions managed with intravitreal injections of ranibizumab in a PRN strategy during 24 months. Retrospective chart review of patients with type 1 CNV recording the visual acuity, number of intravitreal injections, multimodal imaging data, and follow-up period was performed. Subfoveal choroidal thickness was measured using enhanced depth imaging scans obtained with spectral-domain optical coherence tomography. Results Twenty-five eyes of 21 patients were included. The mean baseline logMAR best-corrected visual acuity was 0.52 (+0.35) (median 0.5; range 0.1-1; interquartile range (IQR) 0.3-0.8) and improved to 0.39 (+0.39) (median 0.4; range 0.1-1; IQR 0.2-0.5) by the end of the follow-up (p = 0.038). Subfoveal choroidal thickness was 202.8 (+60.3) μm (median 218; range 81-285; IQR 146-258). Statistical mixed effects model demonstrated an association between rate of improvement of visual acuity with subfoveal choroidal thickness after 24 months (p<0.001) (95% confidence interval 0.0002-0.0001 logMAR month μm); higher thickness values were correlated with better visual acuity. Conclusions Thicker subfoveal choroid was associated with better visual outcomes in patients with type 1 CNV due to nAMD following a strict PRN regimen with intravitreal ranibizumab at 24 months of follow-up.

scholarly journals Short-term choroidal vascular changes after aflibercept therapy for neovascular age-related macular degeneration

2020 ◽  
Author(s):  
Marco Pellegrini ◽  
Federico Bernabei ◽  
Andrea Mercanti ◽  
Stefano Sebastiani ◽  
Enrico Peiretti ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Age Related Macular Degeneration ◽  
Enhanced Depth Imaging ◽  
Vascular Changes ◽  
Age Related ◽  
Luminal Area ◽  
Treatment Naïve ◽  
Pharmacologic Effect ◽  
Imagej Software

Abstract Introduction The purpose of this study was to evaluate choroidal vascular changes in patients with neovascular age-related macular degeneration (nAMD) treated with aflibercept injection over a 3-month period. Methods Enhanced depth imaging optical coherence tomography scans of 60 eyes with treatment-naïve nAMD and 60 unaffected fellow eyes were retrospectively analyzed. Data was collected at baseline and after 3 monthly intravitreal injections of aflibercept. The ImageJ software was used to binarize OCT scans and measure total choroid area (TCA), luminal area (LA), and stromal area (SA). Choroidal vascularity index (CVI) was defined as the ratio of LA to TCA. Results After treatment, subfoveal choroidal thickness (CT) in nAMD eyes significantly decreased from 210. 6 ± 61.6 to 194.6 ± 58.7 μm (P < 0.001), TCA from 1.620 ± 0.502 to 1.500 ± 0.451 mm2 (P < 0.001), LA from 1.075 ± 0.335 to 0.985 ± 0.307 mm2 (P < 0.001), SA from 0.545 ± 0.176 to 0.516 ± 0.153 mm2 (P = 0.005), and CVI from 66.36 ± 2.89 to 65.46 ± 2.87% (P = 0.009). The decrease of CVI after treatment was significantly correlated with baseline CVI (Rs = 0.466, P < 0.001), but not with the change in BCVA and presence of dry macula after treatment (always P > 0.05). Conclusion Choroidal thickness and vascularity significantly decreased after treatment with aflibercept in nAMD eyes. Besides the pharmacologic effect on the neovascular lesion, aflibercept may induce vascular changes also on the underlying choroid.

scholarly journals Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Young Ho Kim ◽  
Boram Lee ◽  
Edward Kang ◽  
Jaeryung Oh
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Soft Drusen ◽  
Pachychoroid Neovasculopathy ◽  
The Common ◽  
Common Pathogenesis ◽  
Clustering Pattern ◽  
Normal Controls

AbstractChoroidal changes have been suggested to be involved in the pathophysiology of both age-related macular degeneration (AMD) and pachychoroid spectrum diseases (PSD). To find out the choroidal characteristics of each disease groups, various groups of AMD and PSD were classified into several clusters according to choroidal profiles based on subfoveal choroidal thickness (CT), peripapillary CT, the ratio of subfoveal CT to peripapillary CT and age. We retrospectively analyzed 661 eyes, including 190 normal controls and 471 with AMD or PSDs. In the AMD groups, eyes with soft drusen or reticular pseudodrusen were belonged to the same cluster as those with classic exudative AMD (all p < 0.001). However, eyes with pachydrusen were not clustered with eyes from other AMD groups; instead, they were classified in the same cluster as eyes from the PSD group (all p < 0.001). In the PSD group, eyes with pachychoroid neovasculopathy were grouped in the same cluster of those with polypoidal choroidal vasculopathy (p < 0.001). The cluster analysis based on the CT profiles, including subfoveal CT, peripapillary CT, and their ratio, revealed a clustering pattern of eyes with AMD and PSDs. These findings support the suggestion that pachydrusen has the common pathogenesis as PSD.

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