scholarly journals Peculiarities of lipid disorders in blood serum in chronic process of cerebral atherosclerosis

1997 ◽  
Vol XXIX (3-4) ◽  
pp. 69-71
Author(s):  
B. A. Osetrov ◽  
А. A. Komissarenko ◽  
L. V. Salycheva
Keyword(s):  
Blood Serum ◽  
Coronary Atherosclerosis ◽  
Lipid Level ◽  
Blood Lipid ◽  
Brain Circulation ◽  
Integral Evaluation ◽  
Lipid Disorders ◽  
Cerebral Atherosclerosis ◽  
Lipid Spectrum

In 107 patients with chronic insufficiency of brain circulation of atherosclerotic genesis (of different expressiveness) lipid level of blood serum is determined, cholesterine coefficient of atherogenecity and supposed by the authors coefficient of lipid disorders are calculated. The obtained results have been compared with data of analogous examination of 78 patients, having atherosclerotic stenocardia of tension. Integral evaluation of blood lipid spectrum with regard to its peculiarities allowed to determine that expressiveness of lipid disorders in patients with cerebral atherosclerosis is not reduced, and is even increased in coronary atherosclerosis.

scholarly journals Paprika Pigments Attenuate Obesity-Induced Inflammation in 3T3-L1 Adipocytes

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Hayato Maeda ◽  
Shuuichi Saito ◽  
Nozomi Nakamura ◽  
Takashi Maoka
Keyword(s):  
Mrna Expression ◽  
Chronic Inflammation ◽  
Lipid Level ◽  
Blood Lipid ◽  
Macrophage Cell ◽  
Lipid Disorders ◽  
Chemotactic Protein ◽  
Adiponectin Mrna ◽  
Necrosis Factor ◽  
Resistin Mrna

Obesity is related to various diseases, such as diabetes, hyperlipidemia, and hypertension. Adipocytokine, which is released from adipocyte cells, affects insulin resistance and blood lipid level disorders. Further, adipocytokine is related to chronic inflammation in obesity condition adipocyte cells. Paprika pigments (PPs) contain large amounts of capsanthin and capsorubin. These carotenoids affect the liver and improve lipid disorders of the blood. However, how these carotenoids affect adipocyte cells remains unknown. Present study examined the effects of PP on adipocytokine secretion, which is related to improvement of metabolic syndrome. In addition, suppressive effects of PP on chronic inflammation in adipocyte cells were analyzed using 3T3-L1 adipocyte cells and macrophage cell coculture experiments. PP promoted 3T3-L1 adipocyte cells differentiation upregulated adiponectin mRNA expression and secretion. Further, coculture of adipocyte and macrophage cells treated with PP showed suppressed interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), monocyte chemotactic protein-1 (MCP-1), and resistin mRNA expression, similarly to treatment with troglitazone, which is a PPARγ ligand medicine. Conclusion. These results suggest that PP ameliorates chronic inflammation in adipocytes caused by obesity. PP adjusts adipocytokine secretion and might, therefore, affect antimetabolic syndrome diseases.

scholarly journals AB1008 METABOLIC DISORDERS IN CHILDREN WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1797.2-1798
Author(s):  
I. Chyzheuskaya ◽  
A. Vishnevskaya ◽  
I. Arher ◽  
T. Matsushko
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lipid Peroxidation ◽  
Blood Serum ◽  
Lupus Erythematosus ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
The State ◽  
Control Group ◽  
Systemic Lupus ◽  
Lipid Spectrum

Background:Systemic lupus erythematosus (SLE) is the most common pathology from the group of systemic diseases of the connective tissue. Currently, the problem of deadly complications in patients with SLE is progressively shifting towards vascular catastrophes, such as strokes and heart attacks. If a few years ago, patients mainly died at a young age from renal failure as a complication of lupus nephritis, now thromboses of various localization are in first place.Objectives:The purpose of the study was to determine the state of lipid peroxidation and antioxidant protection, the main indicators of the lipid spectrum and the state of hemostasis in children with SLE.Methods:25 children with SLE and 20 healthy children were examined in the rheumatology department of the 4th city children’s clinical hospital in Minsk. The lipid spectrum, lipid peroxidation (LPO) and serum ACL, ACW were determined in the Central Research Laboratory of the Belarusian Medical Academy of Postgraduate Education.Results:In children with SLE a significant increase in the content of total cholesterol (5.56±0.36 mmol/l) and a decrease in HDL-cholesterol levels (0.94±0.18 mmol/l) were found in comparison with the control group (3.71±0 69 mmol/L and 1.29±0.33 mmol/l, respectively).A significant (p <0.05) decrease in the concentration of ApoA (85.1 [59.8; 94.9] mg/dl), ApoE (2.1 [1.2; 3, 7] mg/dl) and an increase in ApoB (59.8 [51.9; 67.8] mg/dl) in children with SLE were found compared with the control group (127.2 [122.1; 132.3] mg/dl, 3, 2 [2.3; 5.9] mg/dl and 32.1 [19.9; 50.8] mg/dl, respectively). ApoB / ApoA> 1 was established in 7 (28%) children with SLE.The study found a significant (p <0.05) increase in the level of intermediate (DK233, DK278) and final (MDA) LPO products in the blood serum of children with SLE in comparison with the control group, which indicates the activation of LPO processes in these patients. During the correlation analysis, a positive correlation was established between the levels of DK233, DK278 in blood serum and CRP (rs= 0.87, p <0.001). When studying the main indicators of the blood lipid spectrum in children with SLE, a significant increase in the serum concentration of total lipids (p <0.01) and triglycerides (p <0.001) was revealed when compared with the control group.When determining indicators of coagulation hemostasis, in children with SLE, a predominance of hypercoagulation was detected, accompanied by a significant increase in serum fibrinogen level (5.08 ± 0.14 g/l) and an increase in platelet level (479.57 ± 8.01*109/l) in peripheral blood compared with the control group (3.24 ± 0.07 g / l and 294.23 ± 5.39*109/l, respectively). These indicators correlated with serum CRP concentration (rS = 0.62; p <0.01) and ESR level (rs= 0.73; p <0.01). A relationship was established between elevated serum levels of fibrinogen and disease activity indicators (rs=0.74; p <0.01).Conclusion:The atherogenic orientation of the blood lipid spectrum, characterized by hyperlipidemia, hypertriglyceridemia, hypercholesterolemia and dyslipoproteinemia in the form of a decrease in HDL-cholesterol and an increase in LDL-cholesterol, as well as an increase in ApoB/ApoA ratio> 1 and a decrease in ApoE, the activation of LPO processes and a significant decrease in ACW and ACL in the serum of children with SLE are cardiovascular events risk factors (pulmonary thromboembolism, myocardial infarction and brain).Acknowledgments:This study would not have been possible without the collaboration of numerous Belarusian pediatric rheumatologists, patients and their parents.Disclosure of Interests:None declared

scholarly journals Cloudy Apple Juice Fermented by Lactobacillus Prevents Obesity Via Modulating Gut Microbiota and Protecting Intestinal Tract Health

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 971
Author(s):  
Mengzhen Han ◽  
Meina Zhang ◽  
Xiaowei Wang ◽  
Xue Bai ◽  
Tianli Yue ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Apple Juice ◽  
Intestinal Tract ◽  
Lipid Level ◽  
Blood Lipid ◽  
Obese Mice ◽  
Research Findings ◽  
Gut Microbiota Composition ◽  
Blood Lipid Levels

Obesity and hyperglycemia are two serious chronic diseases that are increasing in incidence worldwide. This research aimed to develop a fermented cloudy apple juice with good hyperglycemia intervention activities. Here, cloudy apple juice (CAJ), cloudy apple juice rich in polyphenols (CAJP) and fermented cloudy apple juice rich in polyphenols (FCAJP) were prepared sequentially, and then the effects of the three apple juices on weight, lipid level, gut microbiota composition and intestinal tract health were evaluated for obese mice induced by a high-fat diet. The research findings revealed that the FCAJP showed potential to inhibit the weight gain of mice, reduce fat accumulation, and regulate the blood lipid levels of obese mice by decreasing the ratio of the Firmicutes/Bacteroidotas, improving the Sobs, Ace, and Chao indexes of the gut microbiota and protecting intestinal tract health. In addition, the FCAJP augmented the abundance of Akkermansia and Bacteroides, which were positively related to SCFAs in cecal contents. This study inferred that FCAJP could be developed as a healthy food for preventing obesity and hyperglycemia.

scholarly journals Adipokiny, insulinorezistentnost' i aktivnost' simpato-adrenalovoy sistemy u yunoshey s ozhireniem, manifestirovavshim v pubertatnyy period

2012 ◽  
Vol 9 (2) ◽  
pp. 49-52 ◽  
Author(s):  
A F Verbovoy ◽  
E V Mitroshina ◽  
Yu A Dolgih
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Young Men ◽  
Blood Lipid ◽  
The Other ◽  
Control Group ◽  
Normal Blood Pressure ◽  
Sympathoadrenal System ◽  
Increased Activity ◽  
Lipid Spectrum

69 young men with obesity manifesting at puberty have been examined. The average age was 19,22±0,26. 17 healthy young men, whose average age was 22 ± 0,72 years old, constituted a control group. The examined were divided according to their blood pressure (BP): the first subgroup included 36 young men with normal blood pressure, the other subgroup included 33 young men with arterial hypertension. Levels of blood lipid spectrum, levels of leptin, resistin, adiponectin, insulin in serum, urinary metanephrine excretion were measured. We obtained the following results: young men with obesity identified atherogenic changes in lipid metabolism, insulin resistance and compensatory hyperinsulinemia. Regardless of the level of blood pressure they showed a significant increase in leptin levels. In the subgroup of patients with hypertension we found increased urinary excretion of metanephrine, indicating increased activity of the sympathoadrenal system and its involvement in the formation of hypertension. The level of adiponectin in the surveyed tended to decrease, more pronounced in the combination of obesity and hypertension.

scholarly journals Lipid content in blood serum at extended burns in children of different age

2008 ◽  
Vol 7 (4) ◽  
pp. 93-99
Author(s):  
S. A. Artemiyev ◽  
N. I. Kamzalakova ◽  
G. V. Bulygin
Keyword(s):  
Lipid Metabolism ◽  
Blood Serum ◽  
Lipid Content ◽  
Burn Injury ◽  
Age Groups ◽  
Early Age ◽  
Severe Burn ◽  
Elder Patients ◽  
Lipid Spectrum ◽  
Severe Burn Injury

Revealed peculiarities of the lipid spectrum of blood serum in children of different age groups have allowed us to determine general regularities of organism’s reaction to a severe burn trauma and to show changes in the lipid metabolism caused by age and functional state of systems and organs. Thus, in early-age children, adaptation reactions break under the conditions of long stress. In elder patients, compensatory abilities are more pronounced, which is indicative of the more adequate reaction to a severe burn injury.

scholarly journals PERBANDINGAN NILAI AGREGASI TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN DISLIPIDEMIA DAN NORMOLIPIDEMIA DI RSUP PROF. DR. R. D. KANDOU MANADO

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Ivan Ch. Sulamanda
Keyword(s):  
Platelet Aggregation ◽  
Analytical Study ◽  
Platelet Reactivity ◽  
Hypothesis Test ◽  
Lipid Level ◽  
Blood Lipid ◽  
Normal Blood ◽  
Blood Lipid Level ◽  
Diabetes Melitus

Abstract: Insulin resistance that occurs in patients with type 2 diabetes mellitus (T2DM), stimulates lipolysis in adipose tissue resulting in increasing of free fatty acid and dyslipidemia. Dyslipidemia is associated with platelet reactivity and thrombogenic potency. Examination of platelet aggregation aims to detect abnormalities of platelet function. This study aimed to obtain the comparison of platelet aggregation values in T2DM patients with dyslipidemia and with normal blood lipid level. This was an observational analytical study, using comparative hypothesis test. This study were conducted on 30 T2DM patients, in which 15 of them have dyslipidemia and the other 15 has normal lipid level. These patients were registered as outpatients of Endocrine and Metabolic Clinic of Prof. Dr. R. D. Kandou Hospital, Manado. Blood samples of patients were processed in Prokita Laboratory, Manado. Platelet aggregation was tested by using 1 set agregometer Chrono - Log model 490, Chrono - Log recorder model 707, and Computer Windows based PC. The T test showed that there were significant differences of the platelet aggregation values with ADP 10 µm agonist between T2DM patients with dyslipidemia and with normal blood lipid level (P = 0.019). Mann-Whitney test showed that there were significant differences of the platelet aggregation values with ADP 5 µm agonist between T2DM patients with dyslipidemia and with normal blood lipid level (P = 0.006). Most patients in this study were elderly (86.7%), with an equal number of men and women. Conclusion: There were significant differences of the platelet aggregation values between T2DM patients with dyslipidemia and with normal blood lipid level, whether using ADP 10 µm agonist or ADP 5 µm agonist. Keywords: platelet aggregation, T2DM, dyslipidemiaAbstrak: Pada pasien diabetes melitus tipe 2 (DMT2), resistensi insulin merangsang lipolisis di jaringan adiposa yang meningkatkan asam lemak bebas sehingga terjadi dislipidemia. Dislipidemia sering dikaitkan dengan peningkatan aktivitas platelet dan potensi trombogenik. Pemeriksaan agregasi trombosit bertujuan untuk mendeteksi abnormalitas fungsi trombosit. Penelitian ini bertujuan untuk melihat perbandingan nilai agregasi trombosit pada pasien DMT2 dengan dislipidemia dan normolipidemia. Penelitian ini bersifat observasional analitik dengan menggunakan metode uji hipotesis komparatif. Subjek penelitian berjumlah 30 orang, terdiri dari 15 pasien DMT2 dengan dislipidemia dan 15 pasien DMT2 dengan normolipidemia yang berobat ke Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Pemeriksaan sampel darah pasien dilakukan di Laboratorium Prokita Manado. Pemeriksaan agregasi trombosit menggunakan 1 set agregometer Chrono - Log model 490, Chrono - Log recorder model 707, Computer Windows based PC. Karakteristik terbanyak pada pasien DMT2 terdapat pada usia tua (86,7%) dengan jenis kelamin laki - laki dan perempuan sama banyak (50%). Hasil uji T menunjukkan terdapat perbedaan bermakna antara nilai agregasi trombosit menggunakan agonis ADP 10 µm pada pasien DMT2 dengan dislipidemia dan normolipidemia (P = 0,019). Uji Mann-Whitney juga menunjukkan terdapat perbedaan bermakna antara nilai agregasi trombosit dengan agonis ADP 5 µm pada pasien DMT2 dengan dislipidemia dan normolipidemia (P = 0,006). Simpulan: Terdapat perbedaan bermakna antara nilai agregasi trombosit pada pasien DMT2 dengan dislipidemia dan normolipidemia baik menggunakan agonis ADP 10 µm maupun ADP 5 µm. Kata kunci: agregasi trombosit, DMT2, dislipidemia

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