scholarly journals Anxiety as one of the factors determining the rate of multiple sclerosis progressing

2000 ◽  
Vol XXXII (3-4) ◽  
pp. 5-9
Author(s):  
A. A. Skorometz ◽  
L. G. Zaslavsky
Keyword(s):  
Multiple Sclerosis ◽  
Healthy Subjects ◽  
Early Stage ◽  
Control Group ◽  
Reactive Anxiety ◽  
Multiple Sclerosis Patients ◽  
Working Out

Results of psychologic examination of 61 patient with multiple sclerosis diagnosed by Poser criteria are described. In most part of patients an increased level of both egocentric and reactive anxiety in comparison with findings of control group of healthy subjects and group of patients with some other neurologic pathology is with certainty determined. It is found that multiple sclerosis in patients with intense egocentric (congenital) anxiety is taking more malignant course. It is concluded that conducting psychologic testing of multiple sclerosis patients on the early stage for probable assessment of the further course of the disease and working out of more individual tactics of treatment is expedient.

scholarly journals Estimation of temporal gait parameters of multiple sclerosis patients in clinical setting using inertial sensors

2016 ◽  
Author(s):  
Julius Griškevičius ◽  
Vigita Apanskienė ◽  
Jurgita Žižienė ◽  
Kristina Daunoravičienė ◽  
Agnė Ovčinikova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Setting ◽  
Inertial Sensors ◽  
Early Stage ◽  
Step Length ◽  
Control Group ◽  
Permanent Disability ◽  
Gait Parameters ◽  
Healthy Control ◽  
Multiple Sclerosis Patients

Multiple sclerosis (MS) is the most frequent neurological disease causing permanent disability in young adults. Subtle walking difficulties, such as reduced walking speed, step length, cadence and increased step width can be detected at an early stage of the disease. Main goal of this research is by using non-invasive wireless inertial sensors measure gait of MS patients in clinical setting and extract temporal biomechanical parameters that would allow objectively evaluate level of disability in MS patients. Analysis of 25-Foot walk showed that the duration of stance phase is approximately 1.6 times greater in MS group than in healthy control group, while the duration of swing phase in MS group is 1.3 times longer. In general, the MS patients are walking approximately 1.6 times slower.

scholarly journals Comparing coping styles, personality traits, and resiliency in multiple sclerosis patients

2021 ◽  
Vol 23 (2) ◽  
pp. 62-67
Author(s):  
Amir Mahdi Katani ◽  
Shahnaz Mohammadi ◽  
Zahra Davoodi ◽  
Somaye Shahmoradi
Keyword(s):  
Multiple Sclerosis ◽  
Personality Traits ◽  
Healthy Subjects ◽  
Coping Styles ◽  
Control Group ◽  
Case Group ◽  
Ways Of Coping Questionnaire ◽  
Resilience Scale ◽  
Multiple Sclerosis Patients ◽  
Control Study

Background and aims: Multiple sclerosis (MS) is a common neurological disorder with complex etiology, which is highly affected by psychological factors. These factors should to be identified to help patients with MS (PwMS). This study aimed to compare coping styles, personality traits, and resiliency in PwMS and healthy subjects. Methods: In this case-control study, we selected 75 PwMS from the members of Tehran MS Society in 2016 as case group and 75 healthy subjects as control group. To collect data, we used the Ways of Coping Questionnaire (WOCQ), Big Five Factor Inventory–Revised, and Conner-Davidson Resilience Scale (CD-RISC). Multivariate analysis of variance (MANOVA) and independent T-Test were used to analyze the data. Results: The results indicated that PwMS use emotion-focused coping styles more often (44.53±9.13, P=0.008) and problem-focused coping styles less often (39.84±5.79, P=0.001) compared to control group. Also, they showed higher scores in neuroticism (32.10±4.80, P=0.001) and lower scores in extraversion and conscientiousness (27.46±7.12, P=0.005 and 32.98+±5.72, P=0.008, respectively). The resiliency levels in these patients were also lower than healthy subjects (68.13±13.90, P=0.021). Conclusion: Our findings indicated that PwMS are more likely to use emotional coping strategies in stressful situations compared to healthy individuals. Moreover, data confirmed that a maladaptive personality configuration, which is specified by high neuroticism, along with low extraversion, conscientiousness, and agreeableness are somehow related to MS.

scholarly journals Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stage

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Agnieszka Morel ◽  
Michał Bijak ◽  
Elżbieta Miller ◽  
Joanna Rywaniak ◽  
Sergiusz Miller ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Early Stage ◽  
Blood Platelets ◽  
Control Group ◽  
Platelet Activity ◽  
Secondary Progressive ◽  
Primary Hemostasis ◽  
Scientific Papers ◽  
Multiple Sclerosis Patients

Multiple sclerosis (MS) is the autoimmune disease of the central nervous system with complex pathogenesis, different clinical courses and recurrent neurological relapses and/or progression. Despite various scientific papers that focused on early stage of MS, our study targets selective group of late stage secondary progressive MS patients. The presented work is concerned with the reactivity of blood platelets in primary hemostasis in SP MS patients. 50 SP MS patients and 50 healthy volunteers (never diagnosed with MS or other chronic diseases) were examined to evaluate the biological activity of blood platelets (adhesion, aggregation), especially their response to the most important physiological agonists (thrombin, ADP, and collagen) and the effect of oxidative stress on platelet activity. We found that the blood platelets from SP MS patients were significantly more sensitive to all used agonists in comparison with control group. Moreover, the platelet hemostatic function was advanced in patients suffering from SP MS and positively correlated with increased production ofO2-∙in these cells, as well as with Expanded Disability Status Scale. We postulate that the increased oxidative stress in blood platelets in SP MS may be primarily responsible for the altered haemostatic properties of blood platelets.

Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients

2019 ◽  
Vol 19 (5) ◽  
pp. 357-363 ◽  
Author(s):  
Maryam Ahmadi ◽  
Farshid Fathi ◽  
Saloomeh Fouladi ◽  
Fereshteh Alsahebfosul ◽  
Mostafa Manian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Frequency Distribution ◽  
Healthy Subjects ◽  
Demyelinating Disease ◽  
Critical Role ◽  
Assay Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
High Resolution Melt ◽  
Multiple Sclerosis Patients

Background:Asthma is a chronic and complex inflammatory disease of the respiratory tract. Also, multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Against this background, IL-33 and IL1RL1 play a critical role in autoimmune and inflammatory disorders. Here, we explored the IL-33 serum level and two potential genetic variants in the IL33 gene and its receptor in Iranian asthma and MS patients.Results:The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05). The frequency distribution of the genotype in rs10204137 variant of IL-33 gene in MS patients and healthy subjects was significantly different (p = 0.013).Methods:This study consisted of asthma (n=140) and MS patients (n=140), and healthy subjects (n=72). Genotyping was carried out in two genetic polymorphisms, rs1342326 variant of IL-33 and rs10204137SNP variant of IL-33 receptor genes, using High- Resolution Melt Real- Time PCR based method. The level of serum IL-33 was also measured using enzyme-linked immunosorbent assay method.Conclusion:Our findings demonstrated that asthma and MS patients had a higher level of IL-33, and IL-33 receptor genetic polymorphism was associated with MS. Further studies in a larger multicenter setting are needed to explore the value of this marker as a risk stratification biomarker.

scholarly journals Biological backlink in multiple sclerosis treatment

2000 ◽  
Vol XXXII (3-4) ◽  
pp. 13-16
Author(s):  
L. G. Zaslavsky ◽  
N. V. Zhukovskaya ◽  
A. A. Skorometz
Keyword(s):  
Multiple Sclerosis ◽  
Main Group ◽  
Control Group ◽  
Beta Activity ◽  
Combined Method ◽  
Results Of Treatment ◽  
Reactive Anxiety ◽  
Multiple Sclerosis Patients ◽  
Reliable Increase ◽  
Multiple Sclerosis Treatment

The results of treatment of 13 patients with reliably determined multiple sclerosis considering biological backlink are described. A combined method of psychoemotional correction developed by Biosvyaz company (EEG-BOS) was used. Control group included 15 multiple sclerosis patients getting just the same basic therapy as in the main group, but without BOS. On completion of the course of 13 sessions there was determined a significant and reliable increase of lowered alpha-activity, the increased beta-activity in the majority of patients of the main group being lowered. In control group these changes were not so significant and unreliable. Along with these findings in patients getting EEG-BOS the average level of reactive anxiety lowered by 30%, and in patients of control group only by 15%. It is suggested to use this method for correction of psychoemotional disturbances in multiple sclerosis patients.

Assessment of biochemical determinants in Multiple Sclerosis patients following the oral administration of β-D-Mannuronic acid [M2000]

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamad Reza Nikouei Moghaddam ◽  
Monireh Movahedi ◽  
Maryam Bananej ◽  
Soheil Najafi ◽  
Nahid Beladi Moghadam ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Uric Acid ◽  
Vitamin D3 ◽  
Chronic Inflammatory Disease ◽  
Toxic Effects ◽  
Control Group ◽  
Therapeutic Effects ◽  
Mannuronic Acid ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients

Background: Multiple sclerosis is an autoimmune chronic inflammatory disease of the central nervous system that can lead to some serious disabilities. Despite using various immunomodulatory and anti-inflammatory drugs that have therapeutic effects, they cannot reduce its progression completely, and have some unwanted side effects too. The immunomodulatory and anti-inflammatory effects of the β-D-Mannuronic acid [M2000] have been proven in several surveys, and the present research was designed to determine its toxicity and therapeutic effects in MS patients. Methods: This study was performed on 15 MS patients who took 25 mg/kg/day the oral form of the β-D-Mannuronic acid for six months, and 15 healthy people as a control group. Serum levels of Urea, Creatinine, GGT, Vitamin D3, Uric acid, and Anti-Phospholipids were compared to evaluate the therapeutic and possible toxic effects of this drug after this period. Results: Non- toxic effects through the study of Urea, Creatinine, GGT, and non-significant changes in Uric acid and AntiPhospholipids levels, besides a significant rise in Vitamin, D3 levels in the M2000 treated cases were found. Conclusions: Our results suggested that β-D-Mannuronic acid is a safe drug and has no toxicity when administered orally and also has some therapeutic effects in MS patients.

scholarly journals Changes in Cerebrospinal Fluid Balance of TNF and TNF Receptors in Naïve Multiple Sclerosis Patients: Early Involvement in Compartmentalised Intrathecal Inflammation

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1712
Author(s):  
Roberta Magliozzi ◽  
Francesco Pezzini ◽  
Mairi Pucci ◽  
Stefania Rossi ◽  
Francesco Facchiano ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Cell ◽  
Protein Pattern ◽  
Fold Change ◽  
Cortical Lesion ◽  
Control Group ◽  
Lesion Volume ◽  
Mri Features ◽  
Csf Levels ◽  
Multiple Sclerosis Patients

An imbalance of TNF signalling in the inflammatory milieu generated by meningeal immune cell infiltrates in the subarachnoid space in multiple sclerosis (MS), and its animal model may lead to increased cortical pathology. In order to explore whether this feature may be present from the early stages of MS and may be associated with the clinical outcome, the protein levels of TNF, sTNF-R1 and sTNF-R2 were assayed in CSF collected from 122 treatment-naïve MS patients and 36 subjects with other neurological conditions at diagnosis. Potential correlations with other CSF cytokines/chemokines and with clinical and imaging parameters at diagnosis (T0) and after 2 years of follow-up (T24) were evaluated. Significantly increased levels of TNF (fold change: 7.739; p < 0.001), sTNF-R1 (fold change: 1.693; p < 0.001) and sTNF-R2 (fold change: 2.189; p < 0.001) were detected in CSF of MS patients compared to the control group at T0. Increased TNF levels in CSF were significantly (p < 0.01) associated with increased EDSS change (r = 0.43), relapses (r = 0.48) and the appearance of white matter lesions (r = 0.49). CSF levels of TNFR1 were associated with cortical lesion volume (r = 0.41) at T0, as well as with new cortical lesions (r = 0.56), whilst no correlation could be found between TNFR2 levels in CSF and clinical or MRI features. Combined correlation and pathway analysis (ingenuity) of the CSF protein pattern associated with TNF expression (encompassing elevated levels of BAFF, IFN-γ, IL-1β, IL-10, IL-8, IL-16, CCL21, haptoglobin and fibrinogen) showed a particular relationship to the interaction between innate and adaptive immune response. The CSF sTNF-R1-associated pattern (encompassing high levels of CXCL13, TWEAK, LIGHT, IL-35, osteopontin, pentraxin-3, sCD163 and chitinase-3-L1) was mainly related to altered T cell and B cell signalling. Finally, the CSF TNFR2-associated pattern (encompassing high CSF levels of IFN-β, IFN-λ2, sIL-6Rα) was linked to Th cell differentiation and regulatory cytokine signalling. In conclusion, dysregulation of TNF and TNF-R1/2 pathways associates with specific clinical/MRI profiles and can be identified at a very early stage in MS patients, at the time of diagnosis, contributing to the prediction of the disease outcome.

Improvement of hand dexterity following motor cortex rTMS in multiple sclerosis patients with cerebellar impairment

2008 ◽  
Vol 14 (7) ◽  
pp. 995-998 ◽  
Author(s):  
G Koch ◽  
S Rossi ◽  
C Prosperetti ◽  
C Codecà ◽  
F Monteleone ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Transcranial Magnetic Stimulation ◽  
Motor Cortex ◽  
Healthy Subjects ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Hand Dexterity ◽  
Time Required ◽  
Multiple Sclerosis Patients ◽  
Cerebellar Symptoms

We tested the effects of 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the motor cortex in multiple sclerosis (MS) subjects with cerebellar symptoms. rTMS improved hand dexterity in cerebellar patients ( n = 8) but not in healthy subjects ( n = 7), as detected by a significant transient reduction of the time required to complete the nine-hole pegboard task. rTMS of the motor cortex may be a useful approach to treat cerebellar impairment in MS patients.

Fatigue, mood and quality of life improve in MS patients after progressive resistance training

2010 ◽  
Vol 16 (4) ◽  
pp. 480-490 ◽  
Author(s):  
U. Dalgas ◽  
E. Stenager ◽  
J. Jakobsen ◽  
T. Petersen ◽  
HJ Hansen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Resistance Training ◽  
Beneficial Effect ◽  
Control Group ◽  
Progressive Resistance Training ◽  
Multiple Sclerosis Patients ◽  
Progressive Resistance

Fatigue occurs in the majority of multiple sclerosis patients and therapeutic possibilities are few. Fatigue, mood and quality of life were studied in patients with multiple sclerosis following progressive resistance training leading to improvement of muscular strength and functional capacity. Fatigue (Fatigue Severity Scale, FSS), mood (Major Depression Inventory, MDI) and quality of life (physical and mental component scores, PCS and MCS, of SF36) were scored at start, end and follow-up of a randomized controlled clinical trial of 12 weeks of progressive resistance training in moderately disabled (Expanded Disability Status Scale, EDSS: 3—5.5) multiple sclerosis patients including a Control group ( n = 15) and an Exercise group ( n = 16). Fatigue (FSS > 4) was present in all patients. Scores of FSS, MDI, PCS—SF36 and MCS—SF36 were comparable at start of study in the two groups. Fatigue improved during exercise by —0.6 (95% confidence interval (CI) —1.4 to 0.4) a.u. vs. 0.1 (95% CI —0.4 to 0.6) a.u. in controls ( p = 0.04), mood improved by —2.4 (95% CI —4.1 to 0.7) a.u. vs. 1.1 (—1.2 to 3.4) a.u. in controls ( p = 0.01) and quality of life (PCS—SF36) improved by 3.5 (95% CI 1.4—5.7) a.u. vs. —1.0 (95% CI —3.4—1.4) a.u. in controls ( p = 0.01). The beneficial effect of progressive resistance training on all scores was maintained at follow-up after further 12 weeks. Fatigue, mood and quality of life all improved following progressive resistance training, the beneficial effect being maintained for at least 12 weeks after end of intervention.

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