scholarly journals Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stage

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Agnieszka Morel ◽  
Michał Bijak ◽  
Elżbieta Miller ◽  
Joanna Rywaniak ◽  
Sergiusz Miller ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Early Stage ◽  
Blood Platelets ◽  
Control Group ◽  
Platelet Activity ◽  
Secondary Progressive ◽  
Primary Hemostasis ◽  
Scientific Papers ◽  
Multiple Sclerosis Patients

Multiple sclerosis (MS) is the autoimmune disease of the central nervous system with complex pathogenesis, different clinical courses and recurrent neurological relapses and/or progression. Despite various scientific papers that focused on early stage of MS, our study targets selective group of late stage secondary progressive MS patients. The presented work is concerned with the reactivity of blood platelets in primary hemostasis in SP MS patients. 50 SP MS patients and 50 healthy volunteers (never diagnosed with MS or other chronic diseases) were examined to evaluate the biological activity of blood platelets (adhesion, aggregation), especially their response to the most important physiological agonists (thrombin, ADP, and collagen) and the effect of oxidative stress on platelet activity. We found that the blood platelets from SP MS patients were significantly more sensitive to all used agonists in comparison with control group. Moreover, the platelet hemostatic function was advanced in patients suffering from SP MS and positively correlated with increased production ofO2-∙in these cells, as well as with Expanded Disability Status Scale. We postulate that the increased oxidative stress in blood platelets in SP MS may be primarily responsible for the altered haemostatic properties of blood platelets.

scholarly journals Estimation of temporal gait parameters of multiple sclerosis patients in clinical setting using inertial sensors

2016 ◽  
Author(s):  
Julius Griškevičius ◽  
Vigita Apanskienė ◽  
Jurgita Žižienė ◽  
Kristina Daunoravičienė ◽  
Agnė Ovčinikova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Setting ◽  
Inertial Sensors ◽  
Early Stage ◽  
Step Length ◽  
Control Group ◽  
Permanent Disability ◽  
Gait Parameters ◽  
Healthy Control ◽  
Multiple Sclerosis Patients

Multiple sclerosis (MS) is the most frequent neurological disease causing permanent disability in young adults. Subtle walking difficulties, such as reduced walking speed, step length, cadence and increased step width can be detected at an early stage of the disease. Main goal of this research is by using non-invasive wireless inertial sensors measure gait of MS patients in clinical setting and extract temporal biomechanical parameters that would allow objectively evaluate level of disability in MS patients. Analysis of 25-Foot walk showed that the duration of stance phase is approximately 1.6 times greater in MS group than in healthy control group, while the duration of swing phase in MS group is 1.3 times longer. In general, the MS patients are walking approximately 1.6 times slower.

scholarly journals Anxiety as one of the factors determining the rate of multiple sclerosis progressing

2000 ◽  
Vol XXXII (3-4) ◽  
pp. 5-9
Author(s):  
A. A. Skorometz ◽  
L. G. Zaslavsky
Keyword(s):  
Multiple Sclerosis ◽  
Healthy Subjects ◽  
Early Stage ◽  
Control Group ◽  
Reactive Anxiety ◽  
Multiple Sclerosis Patients ◽  
Working Out

Results of psychologic examination of 61 patient with multiple sclerosis diagnosed by Poser criteria are described. In most part of patients an increased level of both egocentric and reactive anxiety in comparison with findings of control group of healthy subjects and group of patients with some other neurologic pathology is with certainty determined. It is found that multiple sclerosis in patients with intense egocentric (congenital) anxiety is taking more malignant course. It is concluded that conducting psychologic testing of multiple sclerosis patients on the early stage for probable assessment of the further course of the disease and working out of more individual tactics of treatment is expedient.

scholarly journals Oxidative Stress and Inflammation Interdependence in Multiple Sclerosis

2019 ◽  
Vol 8 (11) ◽  
pp. 1815 ◽  
Author(s):  
Rodica Padureanu ◽  
Carmen Valeria Albu ◽  
Radu Razvan Mititelu ◽  
Manuela Violeta Bacanoiu ◽  
Anca Oana Docea ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Antioxidant Capacity ◽  
Peripheral Blood ◽  
Neuronal Damage ◽  
Early Stage ◽  
Control Group ◽  
Neutrophil Lymphocyte Ratio ◽  
Inflammatory Status ◽  
Relapsing Remitting

The study aims to explore the oxidative status related to inflammation in peripheral blood of stable relapsing-remitting multiple sclerosis (MS) patients with low disability. In this study, 31 people were included and divided into two groups: an MS group in which 16 relapsing-remitting MS patients with a low disability level (age 38.9 ± 7.08, EDSS median 2.5) were included and a control group that contains 15 healthy volunteers of similar age to the MS group. Thiobarbituric acid reactive substances (TBARS), protein carbonyl level (PCO), total antioxidant capacity (TAC) as oxidative stress markers, neutrophil/lymphocyte ratio (NLR), and erythrocyte sedimentation rate (ESR) were analyzed in the peripheral blood sample of the healthy and the MS patients to establish the oxidative stress/inflammatory level using conventional plasma markers. In this study, we showed that the pro-inflammatory status of the relapse-remitting stage of diseases can be easily and accurately appreciated by NLR. An increased NLR is associated with a decreased antioxidant capacity, even in the early stage of neuronal damage. Oxidative stress associated with inflammation aggravates the functional outcome, potentiates neuronal damage, and can accelerate the progression of the disease.

Assessment of biochemical determinants in Multiple Sclerosis patients following the oral administration of β-D-Mannuronic acid [M2000]

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamad Reza Nikouei Moghaddam ◽  
Monireh Movahedi ◽  
Maryam Bananej ◽  
Soheil Najafi ◽  
Nahid Beladi Moghadam ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Uric Acid ◽  
Vitamin D3 ◽  
Chronic Inflammatory Disease ◽  
Toxic Effects ◽  
Control Group ◽  
Therapeutic Effects ◽  
Mannuronic Acid ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients

Background: Multiple sclerosis is an autoimmune chronic inflammatory disease of the central nervous system that can lead to some serious disabilities. Despite using various immunomodulatory and anti-inflammatory drugs that have therapeutic effects, they cannot reduce its progression completely, and have some unwanted side effects too. The immunomodulatory and anti-inflammatory effects of the β-D-Mannuronic acid [M2000] have been proven in several surveys, and the present research was designed to determine its toxicity and therapeutic effects in MS patients. Methods: This study was performed on 15 MS patients who took 25 mg/kg/day the oral form of the β-D-Mannuronic acid for six months, and 15 healthy people as a control group. Serum levels of Urea, Creatinine, GGT, Vitamin D3, Uric acid, and Anti-Phospholipids were compared to evaluate the therapeutic and possible toxic effects of this drug after this period. Results: Non- toxic effects through the study of Urea, Creatinine, GGT, and non-significant changes in Uric acid and AntiPhospholipids levels, besides a significant rise in Vitamin, D3 levels in the M2000 treated cases were found. Conclusions: Our results suggested that β-D-Mannuronic acid is a safe drug and has no toxicity when administered orally and also has some therapeutic effects in MS patients.

scholarly journals Changes in Cerebrospinal Fluid Balance of TNF and TNF Receptors in Naïve Multiple Sclerosis Patients: Early Involvement in Compartmentalised Intrathecal Inflammation

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1712
Author(s):  
Roberta Magliozzi ◽  
Francesco Pezzini ◽  
Mairi Pucci ◽  
Stefania Rossi ◽  
Francesco Facchiano ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Cell ◽  
Protein Pattern ◽  
Fold Change ◽  
Cortical Lesion ◽  
Control Group ◽  
Lesion Volume ◽  
Mri Features ◽  
Csf Levels ◽  
Multiple Sclerosis Patients

An imbalance of TNF signalling in the inflammatory milieu generated by meningeal immune cell infiltrates in the subarachnoid space in multiple sclerosis (MS), and its animal model may lead to increased cortical pathology. In order to explore whether this feature may be present from the early stages of MS and may be associated with the clinical outcome, the protein levels of TNF, sTNF-R1 and sTNF-R2 were assayed in CSF collected from 122 treatment-naïve MS patients and 36 subjects with other neurological conditions at diagnosis. Potential correlations with other CSF cytokines/chemokines and with clinical and imaging parameters at diagnosis (T0) and after 2 years of follow-up (T24) were evaluated. Significantly increased levels of TNF (fold change: 7.739; p < 0.001), sTNF-R1 (fold change: 1.693; p < 0.001) and sTNF-R2 (fold change: 2.189; p < 0.001) were detected in CSF of MS patients compared to the control group at T0. Increased TNF levels in CSF were significantly (p < 0.01) associated with increased EDSS change (r = 0.43), relapses (r = 0.48) and the appearance of white matter lesions (r = 0.49). CSF levels of TNFR1 were associated with cortical lesion volume (r = 0.41) at T0, as well as with new cortical lesions (r = 0.56), whilst no correlation could be found between TNFR2 levels in CSF and clinical or MRI features. Combined correlation and pathway analysis (ingenuity) of the CSF protein pattern associated with TNF expression (encompassing elevated levels of BAFF, IFN-γ, IL-1β, IL-10, IL-8, IL-16, CCL21, haptoglobin and fibrinogen) showed a particular relationship to the interaction between innate and adaptive immune response. The CSF sTNF-R1-associated pattern (encompassing high levels of CXCL13, TWEAK, LIGHT, IL-35, osteopontin, pentraxin-3, sCD163 and chitinase-3-L1) was mainly related to altered T cell and B cell signalling. Finally, the CSF TNFR2-associated pattern (encompassing high CSF levels of IFN-β, IFN-λ2, sIL-6Rα) was linked to Th cell differentiation and regulatory cytokine signalling. In conclusion, dysregulation of TNF and TNF-R1/2 pathways associates with specific clinical/MRI profiles and can be identified at a very early stage in MS patients, at the time of diagnosis, contributing to the prediction of the disease outcome.

The effects of whole-body cryotherapy on oxidative stress in multiple sclerosis patients

2010 ◽  
Vol 35 (8) ◽  
pp. 406-410 ◽  
Author(s):  
Elżbieta Miller ◽  
MaŁgorzata Mrowicka ◽  
Katarzyna Malinowska ◽  
Jerzy Mrowicki ◽  
Joanna Saluk-Juszczak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Whole Body ◽  
Multiple Sclerosis Patients ◽  
Whole Body Cryotherapy

Balanced oxidative stress index in spite of decreased uric acid levels in multiple sclerosis patients

2015 ◽  
Vol 9 (2) ◽  
pp. 153-158 ◽  
Author(s):  
O. Aydin ◽  
F. Kurtulus ◽  
E. Eren ◽  
H. Y. Ellidag ◽  
N. Yılmaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Uric Acid ◽  
Stress Index ◽  
Oxidative Stress Index ◽  
Multiple Sclerosis Patients
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