scholarly journals The role of radiotherapy at specialized treatment of malignant tumors and technical equipment of radiotherapy service in the Republic of Tatarstan

2013 ◽  
Vol 94 (3) ◽  
pp. 381-386
Author(s):  
O V Morov ◽  
R S Khasanov ◽  
A V Chernichenko ◽  
I A Giliazutdinov ◽  
K T Shakirov
Keyword(s):  
Malignant Tumors ◽  
Cancer Center ◽  
First Year ◽  
Technical Equipment ◽  
Complex Treatment ◽  
Number Of Patients ◽  
Healthcare Optimization ◽  
The Republic ◽  
Patient Service

Aim. To study the qualitative indicators for radiotherapy of patients with malignancies and the level of technical equipment of radiotherapy service in the Republic of Tatarstan. Methods. The incidence of malignant tumors, the number of patients treated with radiotherapy at the Tatarstan Regional Clinical Cancer Center since 2002 to 2012 were assessed. The comparative analysis of relative parameters characterizing the radiotherapy service and the level of technical equipment of radiotherapy service in the Republic of Tatarstan compared to Turkey and Japan. Results. The increase in number of patients treated with radiotherapy over time was noted. Nevertheless, compared to data from Turkey and Japan, the share of patients who offered radiotherapy as a method of complex treatment of patients with malignancies in the Republic of Tatarstan stays below the recommended levels compared to Turkey and Japan. Only 18.4% of patients receive radiotherapy during the first year of the disease. The remote radiotherapy equipment rate in the Republic of Tatarstan is twice lower compared to Turkey and Japan. Only 50% of the minimal recommended technical equipment units quantity for remote radiotherapy are available in the Republic of Tatarstan, with over than a half of this number out-of-date. Conclusion. Healthcare optimization and wide use of out-patient service along with modernizing the radiotherapy service allowed to increase the coverage of patients with malignancies with radiotherapy during the last years, hence the use of radiotherapy as a method of complex treatment of patients with malignancies in the Republic of Tatarstan stays below the recommended levels, to increase in further, the re-equipment of the radiotherapy service with the modern equipment for remote radiotherapy is necessary.

THE ROLE OF COMPREHENSIVE GERIATRIC ASSESSMENT IN THE TREATMENT OF CANCER PATIENTS IN ELDERLY AND SENILE AGE

2020 ◽  
pp. 65-73
Author(s):  
Ю. В. Алексеева ◽  
Т. Ю. Семиглазова ◽  
Б. С. Каспаров ◽  
Е. В. Ткаченко ◽  
К. И. Прощаев ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Malignant Tumors ◽  
Adverse Outcomes ◽  
Geriatric Syndromes ◽  
Complex Treatment ◽  
Increase Life Expectancy ◽  
Specialized Treatment

Современные подходы к организации диагностики и лечения больных пожилого и старческого возраста со злокачественными новообразованиями позволяют улучшать качество жизни и увеличивать продолжительность жизни. Оценка гериатрического статуса в онкологии позволяет прогнозировать осложнения в процессе комплексного лечения, в том числе лекарственного, модифицировать терапию для уменьшения факторов риска неблагоприятных исходов, осуществлять отбор пациентов на специализированное лечение с использованием стандартных схем. Таким образом, своевременная оценка гериатрических синдромов и их коррекция способна расширить показания к специализированному лечению больных пожилого и старческого возраста. Modern approaches to the organization of diagnosis and treatment of elderly and senile patients with malignant tumors allow to maintain the necessary level of health, improve the quality of life and increase life expectancy. Assessment of geriatric status in Oncology allows: to predict complications during the complex treatment, including drug treatment; to modify treatment to reduce the risk factors of adverse outcomes; to select patients for specialized treatment using standard schemes. So, timely assessment of geriatric syndromes and their correction can expand the indications for specialized treatment of elderly and senile patients.

CANCER OF THE LARYNX IN THE AMUR REGION OF FAR EASTERN FEDERAL DISTRICT

2016 ◽  
Vol 1 (60) ◽  
pp. 45-51
Author(s):  
Геращенко ◽  
Larisa Gerashchenko ◽  
Гордиенко ◽  
Viktor Gordienko ◽  
Колтыгина ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Federal District ◽  
Amur Region ◽  
First Year ◽  
Cancer Services ◽  
Number Of Patients ◽  
Growth Loss ◽  
Analysis Of Dynamics ◽  
Far Eastern

The article analyzes the main indicators of morbidity and mortality from cancer of the larynx in the period from 1998 to 2014 on the territory of the Amur region of Far Eastern Federal District. In the studied period of time, the incidence of malignant tumors of the larynx substantially decreased with the growth/loss in men of “rough indicators” by -11.89%, of standardized ones by -7.75%. In women, they were +98.31 and +77.77%, respectively. Mortality in contrast to the incidence throughout the years had a negative growth (loss) in absolute terms, “rude” and standardized indicators. The age and sex features of morbidity with larynx cancer were revealed; they show that the maximum number of cancer cases is in the age group of 50 years old and older. The multistage character of the process based on its prevalence was determined. The early stages (I-II) of laryngeal cancer were registered in 13.7% of patients. The quality of cancer services activity was studied by reliability index of accounting for this category of patients, which is usually lower than in other regions of the country (-0.45). The analysis of dynamics of mortality in the first year after diagnosis shows its reduction in cancer of the larynx by 11.0% over the period of 1998-2014. The number of patients who were registered five or more years ago decreased significantly. The estimation of primary care, which is not yet fully in line with current medicine, in the provision of specialized aid to cancer patients in the region was done.

scholarly journals Esophageal cancer: analytical indicators of cancer service efficacy

2020 ◽  
Vol 55 (1) ◽  
pp. 12-15
Author(s):  
K. TOLEUTAIULУ ◽  
A. ZHYLKAYDAROVA ◽  
U. ZHUMASHEV ◽  
S. YESSENKULOVA ◽  
A. JAKIPBAYEVA ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Surgical Treatment ◽  
Early Detection ◽  
Cancer Incidence ◽  
Malignant Tumors ◽  
Stage Iv ◽  
Cancer Service ◽  
Number Of Patients ◽  
Incidence And Mortality ◽  
The Republic

Relevance: Esophageal cancer ranks eighth in the structure of malignant tumors in the Republic of Kazakhstan. According to the Kazakh Institute of Oncology and Radiology, in 2018, 1225 were primarily registered with esophageal cancer, and 825 patients died from this disease. The purpose of this study was to analyze the esophageal cancer incidence and mortality among the population of the Republic of Kazakhstan in 2009-2018 and determine the cancer service efficacy. Results: The analysis of intensive indicators of esophageal cancer incidence showed a decrease in the number of primary cases from 8.2‰ in 2009 to 6.7‰ in 2018, and the mortality – from 6.9‰ to 3.8‰. The share of early detection (Stage I-II) increased by 38.2% since 2009 to reach 52.1% in 2018. The share of stage IV esophageal cancer decreased from 7.2% in 2009 to 5.8% in 2018. One-year mortality decreased by 14.7% since 2009 to reach 41.2% in 2018, which speaks of the improvements in the timely diagnosis of esophageal cancer. The number of patients who received radical comprehensive treatment increased by 8.6% to reach 32.2% in 2018. The number of patients who received surgical treatment in 2009-2018 remained almost at the same level and amounted to 18.9 and 18.0%, respectively. However, during the years of screening for esophageal cancer, the proportion of surgical treatment increased from 26.6% to 30.4%. The ratio of incidence to mortality decreased from 91.4% to 68.8% in the study period indicating an improvement in the level of cancer service in the Republic of Kazakhstan. Conclusion: The analysis of intensive indicators of esophageal cancer incidence showed a decrease in primary incidence. The screening conducted in 2013-2016 has shown an improvement in early detection of esophageal cancer (stages I-II) and a decrease in the share of the advanced stage. The findings of this study shall serve as the basis for planning anti-cancer measures

MOLECULAR DIAGNOSTICS OF BILATERAL BREAST CANCER

2017 ◽  
Vol 63 (3) ◽  
pp. 435-439
Author(s):  
Svetlana Bekhtereva ◽  
Yevgeniy Imyanitov ◽  
Andrey Vazhenin ◽  
Alla Domozhirova ◽  
Sergey Yaytsev
Keyword(s):  
Breast Cancer ◽  
Clinical Practice ◽  
Somatic Mutations ◽  
Malignant Tumors ◽  
Bilateral Breast Cancer ◽  
Genetic Studies ◽  
Number Of Patients ◽  
Genetic Mechanisms ◽  
Prevention Of Breast Cancer

The problem of primary multiplicity of malignant tumors remains actual in oncology due to growing number of patients with polyneoplasia especially of the breast. Modern genetic studies use “genetically enriched” cases of cancer, which include in particular primary-multiple malignant tumors of the breast. Practically every tumor has an individual set of somatic mutations and genetic mechanisms of breast cancer appearance are very different. The multicentre study shows the role of recessive determinants of the predisposition to bilateral breast cancer without a family history. The obtained data could be used in clinical practice as a secondary prevention of breast cancer.

scholarly journals The role of surgeons during the COVID-19 pandemic: The experience of the Surgery Clinic of the Clinical Hospital Center 'Zemun'

2021 ◽  
Vol 2 (3) ◽  
pp. 228-235
Author(s):  
Dragoš Stojanović ◽  
Nebojša Mitrović ◽  
Dejan Stevanović ◽  
Damir Jašarović ◽  
Srđan Milina ◽  
...  
Keyword(s):  
Healthcare System ◽  
Surgical Procedures ◽  
Vascular Diseases ◽  
Hospital Treatment ◽  
Clinical Hospital ◽  
Number Of Patients ◽  
Study Results ◽  
The Republic ◽  
Hospital Center

Introduction: In December 2019, the existence of a new type of disease, caused by SARS coronavirus 2 (SARS-CoV-2), was discovered in the city of Wuhan, the Republic of China. The disease itself is characterized by a large number of patients with moderate and severe clinical presentation, who require hospital treatment. The organization of the healthcare system of Serbia, during the aforementioned pandemic, has required the engagement of all doctors, regardless of their specialty, in the treatment of patients with COVID-19. Surgeons of all branches, from the Surgery Clinic of the Clinical Hospital Center Zemun, were directly engaged in the treatment of both primary manifestations of the virus and the numerous surgical complications arising in the wake of this disease, but also in the treatment of primary acute surgical diseases in COVID-19-positive patients. Aim: The aim of this paper is to present the functioning of the Surgery Clinic of CHC Zemun, in the conditions of the COVID-19 pandemic, as well as to present the types and results of surgical procedures performed in patients with the COVID-19 infection. Methods: This study was conceived as a retrospective study and was conducted in the period between February 2020 and April 2021, in patients who had undergone emergency surgery and in whom the COVID-19 infection had previously been verified. A total of 232 patients surgically treated at the level of the entire Surgery Clinic of the CHC Zemun participated in the study. Results: Chest drainage, due to the development of pneumothorax, accounted for a quarter of all surgical procedures performed, while, in 53.85% of cases, surgical treatment was undertaken due to acute abdomen of various etiology, and in 21.15% of cases, due to vascular diseases. Conclusion: The COVID-19 pandemic is, in itself, a major challenge for the entire healthcare system. The role of the surgeon is significant, both in organization and in direct treatment, which is additionally complicated by the uniqueness of the entire situation and the severity of the disease itself. In addition to their involvement in the treatment of the COVID-19 infection itself, surgeons were, in a large number of cases, engaged in their primary activity in health care, i.e., in the treatment of surgical diseases and complications of COVID-19, performing demanding surgical procedures in very difficult and unique conditions.

scholarly journals Malignant tumors of the pharynx: etiological factors and epidemiological indicators in Ukraine

2020 ◽  
pp. 58-66
Author(s):  
Erwin V. Lukach ◽  
Marina B. Sambur ◽  
Zoya P. Fedorenko ◽  
Yuri O. Serezhko
Keyword(s):  
Genetic Factors ◽  
Malignant Tumors ◽  
Relative Number ◽  
Malignant Neoplasms ◽  
Pharyngeal Cancer ◽  
Papilloma Virus ◽  
Etiological Factors ◽  
Number Of Patients ◽  
World Standard

The authors analyze the epidemiological indicators of morbidity, mortality, age structure, relative number of patients detecting during prophylactic examination and contingent of patients with malignant neoplasms (MN) of the throat in Ukraine and regions according to the Bulletin of National Cancer Registry of Ukraine in 2014-2018. The highest incidence rate per 100,000 population in the regions of Ukraine was found in Transcarpathian (both sexes – 9.6; males – 17.9; females – 2.0), Kirovograd (8.8; 16.9; 1.9) and Khmelnitsky (7.7; 15.9; 0.7) regions. Very low rates of detection of patients with MN of the throat as a whole in Ukraine were observed at the prophylactic examinations: in 2015 – 10.0%, in 2016 – 11.0%. Annually in Ukraine, about 44.0% of patients with visually detectable cancer of the pharynx die within 1 year of diagnosis The mortality rate of patients with MN of the throat in 2017 per 100 thousand population of Ukraine is twice higher (4.5) than the world standard (2.0). The etiological factors that cause cancer and the role of human papilloma virus (HPV) of high oncogenic risk (16; 18 and other types) in the carcinogenesis of squamous cell carcinoma of the throat are considered. The data on genetic factors, features of gene mutation, clinical course, treatment and prognosis in patients with HPV-associated and HPV-negative malignancies of the pharynx are presented. For the prevention of pharyngeal cancer in Ukraine, the feasibility of immunization of children and young women aged 9-25 years with vaccines against HPV "Cervarix" and "Gardasil" is discussed. The authors have proposed suggestions for the early detection and improvement of the effectiveness of treatment of patients with pharyngeal throat.

The role of the surgical method in the complex treatment of laryngeal cancer

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Cristina Albul ◽  
◽  
Gheorghe Tibirna ◽  
Nikolay Gorshkov ◽  
Andrei Tibirna ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Life Expectancy ◽  
Laryngeal Cancer ◽  
Surgical Intervention ◽  
Locally Advanced ◽  
Complex Treatment ◽  
Republic Of Moldova ◽  
The Republic ◽  
Anterior Posterior

As a result of studying the dynamics of the incidence of laryngeal cancer in the Republic of Moldova, in the period from 1980 to 2020. It was found that annually, a malignant tumor of the larynx, on average, about 120 patients fall ill. Over the course of 40 years, 874 patients were identified, of which more than 80% were admitted for treatment at stages 3-4 of the disease. This article studied the results of surgical treatment of 258 patients with locally advanced laryngeal cancer. Based on the characteristics of the spread of laryngeal cancer to neighboring organs and tissues, they gave us the basis to distinguish five main types of surgical intervention: upper, lower, anterior, posterior and lateral. The justification of these operations is proved by the patient’s life expectancy, which is 53.6%.

Incremental oncology workload generated by immunotherapy in the first-year of treatment.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e14143-e14143
Author(s):  
Marika Cinausero ◽  
Silvio Ken Garattini ◽  
Alessandro Marco Minisini ◽  
Francesca Valent ◽  
Chiara Riosa ◽  
...  
Keyword(s):  
Metastatic Cancer ◽  
Rapid Development ◽  
Cancer Center ◽  
First Year ◽  
Number Of Patients ◽  
Clinical Episode ◽  
Student’S T ◽  
Few Data ◽  
New Diagnosis

e14143 Background: The rapid development of immunotherapy (IO) has transformed the cancer therapy landscape with growing impact on oncology workload. Given the few data on this topic, we conducted a study to estimate the shift in workload generated by any new metastatic cancer patient treated with IO and referred to the Oncology Department of the Academic Academic Cancer Center of Udine, Italy, within the 12 months of first consultation. Methods: We collected from our “Data Warehouse” electronic accountability system all new diagnosis of metastatic cancer between 01.01.2017 and 31.12.2018, resulting in a first consultation and leading to a second clinical episode during the following year, in order to assess the oncology workload. The population was divided into patients that received IO (anti-CTLA-4/PD-1/PDL1) versus patients treated with “other treatments”. Mean number per patient and standard deviation were calculated for clinical episodes (first consultations, treatment sessions, unplanned presentations, hospitalizations, re-evaluations, follow-up and inpatient oncology advices). The total number of patients treated and the number of episodes were recorded. Mean numbers of episodes in the IO group and “other treatments” group were compared using Student’s t-test (significance p < 0.005). Follow-up data was collected up to 31.12.2019. Results: A total number of 969 patients were considered (854 “other treatments” group and 115 IO group), resulting in a total of 12407 clinical episodes over the period of 12 months (first consultations excluded). Compared to “other treatments” group, patients in the IO group generated a greater workload in terms of treatment sessions (9.59 vs 6.83 per patient, p < 0.0001), re-evaluations (2.55 vs 1.88, p = 0.0002), and unplanned presentations (2.19 vs 1.51, p = 0.08). On the other hand, follow-up visits workload was greater for “other treatments” group (0.83 vs 0.63, p = 0.0002). No differences were found regarding hospitalizations and inpatient oncology advices. Further analysis will be presented. Conclusions: IO represents a new frontier in oncology landscape, leading to outcome’s improvement and longer lasting treatment periods. The estimate of oncology workload generated by new diagnosis of metastatic cancer requiring IO, is crucial for implementing more sustainable systems and for planning clinical activities.

scholarly journals Esophageal cancer: analytical indicators of cancer service efficacy

2020 ◽  
Vol 55 (1) ◽  
pp. 14-18
Author(s):  
K. Toleutaiulу ◽  
A. Zhylkaydarova ◽  
U. Zhumashev ◽  
S. Yessenkulova ◽  
A. Jakipbayeva ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Surgical Treatment ◽  
Cancer Incidence ◽  
Malignant Tumors ◽  
Stage Iv ◽  
Comprehensive Treatment ◽  
Cancer Service ◽  
Number Of Patients ◽  
Incidence And Mortality ◽  
The Republic

Relevance: Esophageal cancer ranks eighth in the structure of malignant tumors in the Republic of Kazakhstan. According to the Kazakh Institute of Oncology and Radiology, in 2018, 1225 were primarily registered with esophageal cancer, and 825 patients died from this disease. The purpose of this study was to analyze the esophageal cancer incidence and mortality among the population of the Republic of Kazakhstan in 2009-2018 and determine the cancer service efficacy. Results: The analysis of intensive indicators of esophageal cancer incidence showed a decrease in the number of primary cases from 8.2‰ in 2009 to 6.7‰ in 2018, and the mortality – from 6.9‰ to 3.8‰. The share of early detection (Stage I-II) has increased by 38.2% since 2009 to reach 52.1% in 2018. The share of stage IV esophageal cancer has decreased from 7.2% in 2009 to 5.8% in 2018. One-year mortality has decreased by 14.7% since 2009 to reach 41.2% in 2018, which speaks of the improvements in the timely diagnosis of esophageal cancer. The number of patients who received radical comprehensive treatment has increased by 8.6% to reach 32.2% in 2018. The number of patients who received surgical treatment in 2009-2018 remained almost at the same level and amounted to 18.9 and 18.0%, respectively. However, during the years of screening for esophageal cancer, the proportion of surgical treatment has increased from 26.6% to 30.4%. The ratio of incidence to mortality has decreased from 91.4% to 68.8% in the study period indicating an improvement in the level of cancer service in the Republic of Kazakhstan. Conclusion: The analysis of intensive indicators of esophageal cancer incidence showed a decrease in primary incidence. The screening conducted in 2013-2016 has shown an improvement in early detection of esophageal cancer (stages I-II) and a decrease in the share of the advanced stage. The findings of this study shall serve as the basis for planning anti-cancer activities

scholarly journals Current State of the Autoimmune Thyroiditis Problem

2019 ◽  
pp. 4-13
Author(s):  
V. A. Rozhko
Keyword(s):  
Thyroid Gland ◽  
Autoimmune Thyroiditis ◽  
Convincing Evidence ◽  
Current State ◽  
Number Of Patients ◽  
Increased Risk ◽  
Study Results ◽  
The Republic

The review provides up-to-date data on pathogenetic mechanisms, opportunities of diagnosis, and organizational and medical measures concerning autoimmune thyroiditis (AIT). AIT is a polyetiological disease which is mainly caused by environmental factors, genetic predisposition and disorder in immune regulation. Primary AIT incidence in the Republic of Belarus in 2017 is 58 cases per 100,000 population in the overall structure of the thyroid gland pathology, the AIT accounts for up to 40 %. The upward trend in the number of autoimmune diseases of the thyroid gland, including that in ecologically unfavorable regions, is explained not only by the true increase in the number of patients with AIT, the consequences of stress, but also by the overdiagnosis. There is contradictory data on the correlation of the level of iodine sufficiency of the population with the AIT development; there is no convincing evidence of the role of radiation factors in increasing the risk of AIT. The review analyzes the correlation of AIT with an imbalance in a number of microelements involved in the synthesis of thyroid hormones and affecting the iodine exchange. The article presents the study results that determined the nature of immune disorders in AIT and hypothyroidism in such forms as disorders of lymphocyte subpopulations, proinflammatory and anti-inflammatory cytokines, changes in the apoptosis mechanisms, which were proposed for use as predictors of the severity of thyroid immune inflammation and hypothyroidism. The criteria for selecting patients with an increased risk of developing AIT complications remain unclear, that necessitates the development and implementation of additional organizational and medical measures for following-up of such patients and assessing their quality of life.

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