scholarly journals The features of neuroendocrine changes in cranial injury associated with diabetes mellitus

2013 ◽  
Vol 94 (4) ◽  
pp. 560-565
Author(s):  
V M Meretskyy ◽  
M M Korda
Keyword(s):  
Diabetes Mellitus ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Data Analysis ◽  
Serum Concentration ◽  
Experimental Diabetes ◽  
Experimental Diabetes Mellitus ◽  
Autonomic Nervous ◽  
White Rats ◽  
Cranial Injury

Aim. To study the features of neuroendocrine regulation in cranial injury associated with diabetes mellitus. Methods. Experiments were carried out on 100 male white rats that were divided into the following groups: the first group (n=10) - control group consisted of 10 intact animals, the second group (n=40) - rats with simulated traumatic cranial injury, the third group (n=10) - rats with experimental diabetes mellitus, the fourth group (n=40) - rats with simulated traumatic cranial injury and experimental diabetes mellitus. Experimental diabetes mellitus was induced by a single streptozotocin solution intraperitoneal injection. Animals were withdrawn from the experiment at 3, 24 hours, 5 and 14 days after the traumatic cranial injury. The mathematical analysis of the cardiac rhythm variability was performed by ECG intervals data analysis. Corticosterone serum levels were measured using ELISA. Results. Based on a comprehensive ECG intervals data analysis, it was found that after experimental traumatic cranial injury the imbalance of autonomic nervous system with increased sympathetic autonomic nervous system function occurs, manifesting as a deregulation of cholinergic and adrenergic effects on sinoatrial node. In diabetes, an increase of the role of sympathetic effects on the sinus node functioning also occurred. Revealed autonomic nervous system deregulation after experimental traumatic cranial injury associated with experimental diabetes mellitus were associated with sympathetic autonomic nervous system over-function, parasympathetic autonomic nervous system exhausting and decreased recovery speed. There was a relevant increase in corticosterone serum concentration reaching its maximum 24 hours after traumatic cranial injury. Conclusion. A significant autonomic nervous system sympathetic shift and autonomic regulation intensifying characterizes the clinical course in traumatic cranial injury associated with diabetes mellitus, a positive correlation of corticosterone serum concentration and sympathetic autonomic nervous system over-function was revealed in animals with experimental traumatic cranial injury, particularly when associated with experimental diabetes mellitus.

scholarly journals Peculiarities of vegetative provision and disorders of tolerance to exercise in children with endocrine and cardiac pathology

2020 ◽  
Vol 24 (4) ◽  
pp. 634-639
Author(s):  
K. Shtrakh ◽  
O. Tsiura ◽  
L. Rak ◽  
N. Shevchenko
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Arterial Hypertension ◽  
Exercise Tolerance ◽  
The State ◽  
Cardiac Pathology ◽  
Autonomic Nervous ◽  
Autonomic Support

Annotation. The aim – to find out the features of autonomic support and exercise tolerance of the cardiovascular system in children with chronic non-infectious diseases, in the future will be able to improve the results of diagnosis and rehabilitation of patients, as well as differentially regulate the mode of the exercise regime for patients. The study included 58 children aged 10-17 years, with cardiac and endocrine pathology: group 1 – 23 children with endocrine pathology (type 1 diabetes mellitus), group 2 – 23 children with cardiac pathology (AH stages I-II). The study included clinical examinations, anthropometry, a questionnaire of physical activity by MAOFA, ECG, ultrasound examination of the heart and Rufier's test were performed. Assessment of the state of the autonomic nervous system was carried out using the Kerdo index and COT. Statistical analysis was performed using s/n program SPSS 17 4a 180844250981. It was found that there is a tendency to outstrip the normative values and increased body weight indicators in the examined children with chronic pathology of the endocrine and cardiovascular systems. According to the Rufier test, it was found that in the group of children with diabetes mellitus, 69.5±9.6% of the examined had low results. Among children with hypertension, 30.7±10.4% of the test indicators were regarded as weak, and in 26.9±5.8% – unsatisfactory. The results of Rufier's test were significantly lower in children with endocrine pathology, both in comparison with the group of children with cardiac pathology (p<0.05) and with the control group (p≤0.001). In 70.0±15.3% of cases, weak and unsatisfactory indicators of the Ruffier test were observed against the background of hyperdiastolic autonomic support. In physically nonactive adolescents, asympathicotonic and hyperdiastolic types of COT were observed. Thus, almost 70% of children with diabetes mellitus and 57% of children with arterial hypertension have reduced exercise tolerance. This is associated with hyperdiastolic autonomic support. Physical activity has a positive effect on the state of the autonomic nervous system in children with arterial hypertension and diabetes mellitus.

scholarly journals Desnutrição perinatal e o controle hipotalâmico do comportamento alimentar e do metabolismo do músculo esquelético

2012 ◽  
Vol 25 (3) ◽  
pp. 403-413 ◽  
Author(s):  
Adriano Bento-Santos ◽  
Leonardo dos Reis Silveira ◽  
Raul Manhães-de-Castro ◽  
Carol Gois Leandro
Keyword(s):  
Diabetes Mellitus ◽  
Skeletal Muscle ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Energy Metabolism ◽  
Feeding Behavior ◽  
Developmental Plasticity ◽  
Protein Malnutrition ◽  
Autonomic Nervous

A deficiência de nutrientes durante os períodos críticos do desenvolvimento tem sido associada com maior risco para desenvolver obesidade e diabetes Mellitus na vida adulta. Um dos mecanismos propostos refere-se à regulação do comportamento alimentar e às alterações do metabolismo energético do músculo esquelético. Recentemente, tem sido proposta a existência de uma comunicação entre o hipotálamo e o músculo esquelético a partir de sinais autonômicos que podem explicar as repercussões da desnutrição perinatal. Assim, esta revisão tem como objetivo discutir as repercussões da desnutrição perinatal sobre o comportamento alimentar e o metabolismo energético muscular e a comunicação existente entre o hipotálamo e o músculo via sinais adrenérgicos. Foram utilizadas as bases de dados MedLine/PubMed, Lilacs e Bireme, com publicações entre 2000 e 2011. Os termos de indexação utilizados foram: feeding behavior, energy metabolism, protein malnutrition, developmental plasticity, skeletal muscle e autonomic nervous system. Concluiu-se que a desnutrição perinatal pode atuar no controle hipotalâmico do comportamento alimentar e no metabolismo energético muscular, e a comunicação hipotálamo-músculo pode favorecer o desenvolvimento de obesidade e comorbidades durante o desenvolvimento.

scholarly journals The Role of the Autonomic Nervous System on Cardiac Rhythm during the Evolution of Diabetes Mellitus Using Heart Rate Variability as a Biomarker

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Alondra Albarado-Ibañez ◽  
Rosa Elena Arroyo-Carmona ◽  
Rommel Sánchez-Hernández ◽  
Geovanni Ramos-Ortiz ◽  
Alejandro Frank ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Early Diagnosis ◽  
Negative Symptoms ◽  
Heart Rhythm ◽  
Autonomic Nervous ◽  
Cardiovascular Morbidity And Mortality

Heart rate variability (HRV) is highly influenced by the Autonomic Nervous System (ANS). Several illnesses have been associated with changes in the ANS, thus altering the pattern of HRV. However, the variability of the heart rhythm is originated within the Sinus Atrial Node (SAN) which has its own variability. Still, although both oscillators produce HRV, the influence of the SAN on HRV has not yet been exhaustively studied. On the other hand, the complications of diabetes mellitus (DM), for instance, nephropathy, retinopathy, and neuropathy, increase cardiovascular morbidity and mortality. Traditionally, these complications are diagnosed only when the patient is already suffering from the negative symptoms these complications implicate. Consequently, it is of paramount importance to develop new techniques for early diagnosis prior to any deterioration on healthy patients. HRV has been proved to be a valuable, noninvasive clinical evidence for evaluating diseases and even for describing aging and behavior. In this study, several ECGs were recorded and their RR and PP intervals were analyzed to detect the interpotential interval (ii) of the SAN. Additionally, HRV reduction was quantified to identify alterations in the nervous system within the nodal tissue via measuring the SD1/SD2 ratio in a Poincaré plot. With 15 years of DM development, the data showed an age-dependent increase in HRV due to the axon retraction of ANS neurons from its effectors. In addition, these alterations modify the heart rhythm-producing fatal arrhythmias. Therefore, it is possible to avoid the consequences of DM identifying alterations in SAN previous to its symptomatic appearance. This could be used as an early diagnosis indicator.

scholarly journals Dynamics of heart rate variability analysed through nonlinear and linear dynamics is already impaired in young type 1 diabetic subjects

2016 ◽  
Vol 26 (7) ◽  
pp. 1383-1390 ◽  
Author(s):  
Naiara M. Souza ◽  
Thais R. Giacon ◽  
Francis L. Pacagnelli ◽  
Marianne P. C. R. Barbosa ◽  
Vitor E. Valenti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Type 1 Diabetes Mellitus ◽  
Autonomic Nervous ◽  
Young Subjects

AbstractBackgroundAutonomic diabetic neuropathy is one of the most common complications of type 1 diabetes mellitus, and studies using heart rate variability to investigate these individuals have shown inconclusive results regarding autonomic nervous system activation.AimsTo investigate the dynamics of heart rate in young subjects with type 1 diabetes mellitus through nonlinear and linear methods of heart rate variability.MethodsWe evaluated 20 subjects with type 1 diabetes mellitus and 23 healthy control subjects. We obtained the following nonlinear indices from the recurrence plot: recurrence rate (REC), determinism (DET), and Shanon entropy (ES), and we analysed indices in the frequency (LF and HF in ms2 and normalised units – nu – and LF/HF ratio) and time domains (SDNN and RMSSD), through analysis of 1000 R–R intervals, captured by a heart rate monitor.ResultsThere were reduced values (p<0.05) for individuals with type 1 diabetes mellitus compared with healthy subjects in the following indices: DET, REC, ES, RMSSD, SDNN, LF (ms2), and HF (ms2). In relation to the recurrence plot, subjects with type 1 diabetes mellitus demonstrated lower recurrence and greater variation in their plot, inter-group and intra-group, respectively.ConclusionYoung subjects with type 1 diabetes mellitus have autonomic nervous system behaviour that tends to randomness compared with healthy young subjects. Moreover, this behaviour is related to reduced sympathetic and parasympathetic activity of the autonomic nervous system.

scholarly journals THE EVOKED ACTIVITY OF THE DORSAL ROOT AFFERENT FIBRES OF THE SPINAL CORD OF WHITE RATS IN EXPERIMENTAL DIABETES MELLITUS

2015 ◽  
Vol 61 (1) ◽  
pp. 72-77
Author(s):  
A.G. Rodinsky ◽  
◽  
E.G. Zinov’eva ◽  
А.S. Trushenko ◽  
M.J. Kachan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Spinal Cord ◽  
Dorsal Root ◽  
Experimental Diabetes ◽  
Experimental Diabetes Mellitus ◽  
White Rats ◽  
Evoked Activity

scholarly journals Mitochondrial oxidation in the internal organs of rats with cranial injury and diabetes mellitus

2013 ◽  
Vol 94 (5) ◽  
pp. 621-627
Author(s):  
V M Meretskyy
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
Succinate Dehydrogenase ◽  
Cytochrome Oxidase ◽  
Experimental Diabetes ◽  
Oxidative Modification ◽  
Experimental Diabetes Mellitus ◽  
Mitochondrial Oxidation ◽  
Potassium Atpase ◽  
Cranial Injury

Aim. To study the relation between the processes of mitochondrial oxidation and the intensity of lipid peroxidation, pulmonary and cardiac proteins oxidative modification at cranial injury, diabetes mellitus and at both. Methods. Experiments were carried out on 100 male white rats distributed to the following groups: the first group (n=10) - control group consisted of 10 intact animals, the second group (n=40) - rats with simulated cranial injury, the third group (n=10) - rats with experimental diabetes mellitus, the fourth group (n=40) - rats with simulated cranial injury and experimental diabetes mellitus. Experimental diabetes was induced by a single intraperitoneal injection of streptozotocin solution. Animals were withdrawn from the experiment at 3, 24 hours, 5 and 14 days after the cranial injury. Cardiac and pulmonary energy supply was estimated by the activity of succinate dehydrogenase, cytochrome oxidase and hydrogen potassium ATPase, as well as by the level of adenine nucleotides. Intensity of free-radical protein and lipid peroxidation was assessed by measuring the levels of neutral and base aldehyde and ketone derivatives and active products reacting with thiobarbituric acid. Results. Decrease of succinate dehydrogenase, cytochrome oxidase activity, a significant increase of hydrogen potassium ATPase activity in heart and lungs mitochondria was observed in rats with cranial injury, diabetes mellitus and especially with both conditions. Adenosine triphosphate tissue reserves have significantly decreased, while adenosine diphosphate and monophosphate levels increased, lipid peroxidation and protein oxidation processes activated. Conclusion. In rats with cranial injury associated with diabetes mellitus, lipid and protein peroxidation intensity parameters, the intensity of oxidative stress and the levels of macroergic substanses were significantly worse compared to the same parameters in the injured animals with normal blood glucose level.

scholarly journals A Study of autonomic nervous system dysfunction among patient with diabetes mellitus: a cross sectional study

2017 ◽  
Vol 4 (2) ◽  
pp. 406 ◽  
Author(s):  
Sidheshwar Virbhadraappa Birajdar ◽  
Sheshrao Sakharam Chavan ◽  
Sanjay A. Munde ◽  
Yuvraj P. Bende
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Peripheral Neuropathy ◽  
Autonomic Neuropathy ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Diabetic Autonomic Neuropathy ◽  
Autonomic Nervous

Background: Neuropathy is a common complication of diabetes mellitus and it may affect both the peripheral nerves and autonomic nervous system. It’s prevalence ranges from 1% to 90%. The present study is therefore designed to investigate autonomic nervous system involvement in diabetes mellitus by using simple bedside tests and to study its association with other diabetic angiopathies.Methods: 100 patients of diabetes mellitus were selected in the study. In Autonomic function tests for evaluating parasympathetic damage E: I ratio, 30:75 ratio and Valsalva ratio test was performed. Sympathetic damage was diagnosed by Blood pressure response to standing test and Blood pressure response to sustained handgrip test.Results: Abnormal E:I ratio was noticed in only 24 patients. The 30:15 ratio was found to be abnormal in 38 patients while the Valsalva Ratio was abnormal in 34 patients. Postural hypotension was observed in only 8% patients. The sustained hand grip test was abnormal in 10 patients. The prevalence of cardiac autonomic neuropathy was 58%. The association between the presence of autonomic neuropathy and peripheral neuropathy was statistically significant. However, the association between autonomic neuropathy and retinopathy and nephropathy was not statistically significant.Conclusions: The overall prevalence of autonomic neuropathy in diabetes mellitus was 58%. There was parasympathetic preponderance over sympathetic nervous system in the involvement of diabetic autonomic neuropathy. There was statistically significant association of diabetic autonomic neuropathy with peripheral neuropathy as compared to retinopathy and nephropathy.

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